摘要:

The value of four amniotic fluid tests – the lecithin/sphingomyelin ratio, the presence of phosphatidylglycerol, amniotic fluid cytology and the creatinine concentration – in the prediction of fetal lung maturity was investigated. The sensitivity was high for all tests except for amniotic fluid cytology, which had a higher specificity. The overall outcome, particularly the value for predicting immaturity, was improved by various combinations of tests. The combination of amniotic fluid cytology and creatinine proved useful in predicting the gestational age. A diagram for estimation of gestational age is presented.

ISSN:0378-7346    

DOI:10.1159/000299289

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

To elucidate the local immunological reactions operative in the human papillomavirus (HPV)-induced lesions of the uterine cervix, a total of 150 cervical biopsies containing a dysplastic or a neoplastic change with (CO, 97 cases) or without (NCO, 53 cases) a coexistent HPV lesion (a flat, an inverted or a papillomatous condyloma) were subjected to ANAE (acid α-naphthyl acetate esterase) staining of the immunocompetent cells; B and T lymphocytes, mononuclear phagocytes (MPS cells). In addition, HPV antigens were demonstrated by an indirect immunoperoxidase-PAP method. Age of the patients did not influence the proportions of B, T and MPS cells. Degree of epithelial atypia was inversely related to proportion of B cells in NCO but not in CO series, and directly related to proportions of T cells in CO series, the latter T cell increase being most probably ascribable to the appearance of suppressor T cells. Unlike in the different types of skin warts (caused by divergent HPV types), the type of the cervical condyloma did not affect the proportions of B, T and MPS cells, suggesting a common HPV type as a causative agent of the latter. MPS and T cells were more numerous in HPV-positive condylomas than in HPV-negative ones, supporting the concept that cell-mediated immune mechanisms recognize the surface antigens of the virus-transformed cells coded by the viral genome in the host cell nuclei (HPV+). The findings are discussed in terms of the immune mechanisms involved in rejection of HPV lesions in general, and those of the uterine cervix especially. The full significance of these mechanisms can only be understood when adequate follow-up data of the lesions are at hand.

ISSN:0378-7346    

DOI:10.1159/000299290

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

Electrophoretic systems were used to quantify and characterize the main proteins involved in myometrium contraction, i.e., myosin, actin, and tropomyosin. Skeletin, a cytoskeletal component was also investigated. No difference in their respective concentrations could be found in 13 uteri representing various menstrual cycle stages, postmenopausal conditions, and different gestational ages. The great variability of their tissular level observed in each of the uteri does, however, reflect the heterogeneity of the muscular component of the uterine wall. Comparison of the different forms of actin in gravid and non-gravid uteri showed an increase of the γ-form in gravid uteri. However, myosins purified from gravid and non-gravid uteri were shown to have identical ATPase activity and peptide patterns following limited chymotryptic proteolysis

ISSN:0378-7346    

DOI:10.1159/000299293

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

The effects of nicardipine, a calcium-entry blocker which also has a potent phosphodiesterase inhibitory action, were investigated on isolated human term-pregnant and nonpregnant myometrium, and compared with those of nifedipine. Both drugs relaxed pregnant and nonpregnant myometrial preparations contracted by potassium (127 mM), and also reduced or abolished contractions occurring spontaneously, or induced by pros-taglandin F2α, oxytocin and vasopressin. However, the effect of nicardipine had a slower onset of action than that of nifedipine, and the drug was significantly more potent than nifedipine in pregnant but not in nonpregnant myometrium. It is concluded that in vitro nicardipine is at least as effective as nifedipine. If the differences between the drugs can be reproduced also in vivo, nicardipine offers an interesting alternative to nifedipine for inhibition of undesired uterine activity.

ISSN:0378-7346    

DOI:10.1159/000299294

出版商:S. Karger AG    

年代:1983

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000299297

出版商:S. Karger AG    

年代:1983

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000299299

出版商:S. Karger AG    

年代:1983

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000299300

出版商:S. Karger AG    

年代:1983

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000299303

出版商:S. Karger AG    

年代:1983

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000283689

出版商:S. Karger AG    

年代:1902

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000283692

出版商:S. Karger AG    

年代:1902

数据来源: Karger