摘要:

The levels of five oncofetal antigens were measured in ovarian cyst fluids. Significantly raised levels of carcinoembryonic antigen (CEA), human chorionic gonadotropin, β2-microglobulin, and α-fetoprotein were found in ovarian cyst samples. Human placental lactogen was not detectable in any samples. Mucinous cyst fluids demonstrated higher levels of CEA than serous fluids in both malignant and benign conditions. We could not distinguish between malignant and benign conditions with any of the markers. Except for CEA, there is no difference in values between mucinous and serous cystadenocarcinomas.

ISSN:0378-7346    

DOI:10.1159/000299065

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

Peripheral blood lymphocytes from 105 patients with various degrees of cervical dysplasia (normal/mild, moderate and severe) up to carcinoma in situ were assayed for natural killer cell activity against K562 cells and Chang liver cells in vitro. No difference was found between the natural killer cell activities of any of the groups of patients studied. In addition, the K cell activity of the patients’ lymphocytes was assayed in an antibody-dependent cellular cytotoxicity assay on Chang liver cells with anti-Chang cell antiserum. No difference was found between patient groups. There was no correlation between the presence of antibodies in the patients’ serum to cytomegalovirus measured by anti-complement immunofluorescence and increased natural killer cell activity.

ISSN:0378-7346    

DOI:10.1159/000299066

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

Two commonly taken over-the-counter analgesics, aspirin and acetaminophen, were compared for: effect on total menstrual loss, effect on total days of menstruation, and effect in reduction of pain due to headaches and/or menstrual cramps. Drugs were administered during a 4-month study according to a double-blind format. During the first 2 months, subjects ingested no drugs whatsoever during their menstrual periods. During the second 2 months, subjects ingested aspirin, acetaminophen, or placebo at the rate of two 325-mg tablets every 4 h to total 8 tablets per day during the first 3 days of their menstrual periods. Statistical analysis of the first 2 periods compared to the last 2 showed no differences in total menstrual weights. The number of days of menstruation in the placebo group was significantly lower (p = 0.0137) than in its own control or in the other groups. Neither analgesic showed a signficant reduction in pain due to headache or cramps, although acetaminophen appeared to be slightly more effective than aspirin in reducing menstrual cramps.

ISSN:0378-7346    

DOI:10.1159/000299067

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

The influence of steroid hormones on lipoprotein metabolism has been investigated in menstruating women undergoing oophorectomy; indeed, by this procedure, it is possible to alter selectively the secretion of the hormones and thus to determine the influence of their withdrawal on blood lipids. Within 3 months of surgery we observed significant rapid changes in cholesterol levels of total and HDL-bound components (early decrease and subsequent increase) without alteration of the triglyceride component of the lipoproteins. Similar biphasic changes were observed for the apolipoproteins A and B, determined by immunological methods. These results are suggestive of an action of sex hormones on the lipoprotein metabolism, both on the lipid and the protein moieties. They can be explained by a primary action of the hormones on the apolipoprotein metabolism and a secondary apoprotein-mediated effect on the lipid component of the lipoproteins.

ISSN:0378-7346    

DOI:10.1159/000299068

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

The antiestrogenic effects of tamoxifen and estriol were compared in 39 post-menopausal women during estrogen replacement therapy. Subfractions of HDL cholesterol and its apolipoproteins and the serum levels of two estrogen sensitive liver proteins were followed during three cycles of unopposed estrogen therapy with 10 μg ethinyl estradiol daily. During the last 10 days of the following three cycles the women received sequential addition of either 10 mg tamoxifen twice daily or 2 mg estriol twice daily. Tamoxifen clearly reduced the estrogen-induced increase of apolipoprotein AI, HDL2 cholesterol and total HDL cholesterol. In comparison the pregnancy zone protein and sex hormone-binding globulin were more sensitive to the estrogenic as well as to the antiestrogenic effect than the lipoproteins. Tamoxifen also counteracted the therapeutic effect on climacteric symptoms and it seems unlikely that this compound may be clinically useful as an alternative to progestogens during estrogen replacement therapy. The sequential addition of estriol had no apparent effects as compared to unopposed estrogen treatment.

ISSN:0378-7346    

DOI:10.1159/000299069

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

The results obtained by insemination with 3,418 frozen donor ejaculates with known semen characteristics were analyzed. The concentrations of motile spermatozoa before and after thawing were significantly higher in samples from donors producing pregnancies compared to samples from donors not causing pregnancies. In ejaculates known specifically to have caused a pregnancy even higher concentrations were found. It was assumed that the concentration of motile spermatozoa after thawing was the most important parameter, and by dividing the material into fractions it could be demonstrated that a spermatozoa concentration of more than 20 million/ml is essential for reasonable results.

ISSN:0378-7346    

DOI:10.1159/000299070

出版商:S. Karger AG    

年代:1984

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000299071

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

The interest of the zinc content of amniotic fluid and its relationship to different maternal and fetal parameters is recent. It was reported that the zinc content of amniotic fluid increases in the course of pregnancy probably as an indirect indicator of an increased rate of protein synthesis. These considerations and the known important metabolic role of zinc led us to study the zinc content of amniotic fluid and its importance in the growth and development of the fetus. Amniotic fluid samples of 24 women with normal pregnancies and normal term deliveries were studied. The samples were obtained between weeks 29 and 42 of gestation by transabdominal amniocentesis and the zinc content was determined by means of atomic absorption spectrophotometry. The zinc content of amniotic fluid increases significantly during the third trimester. A positive linear correlation was found between the zinc concentration of amniotic fluid and fetal weight and length. Fetal growth and development would depend on the zinc available due to its biological functions and thus the increase of zinc concentration of amniotic fluid in the last weeks of gestation and its correlation with fetal weight and length. These results suggest that the determination of zinc content of amniotic fluid can be useful in the assessment of fetal development and well-being, and of the course of pregnancy.

ISSN:0378-7346    

DOI:10.1159/000299072

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

Calcium, parathyroid hormone (PTH) and calcitonin (CT) in serum, and the fractional renal excretion of calcium (FECa) were determined in (1) normal pregnant women, (2) patients with preeclampsia, and (3) normal nonpregnant control subjects. Serum calcium, corrected for individual variation in serum protein, was reduced and FECa increased in the normal pregnant group when compared to the nonpregnant control group. In preeclampsia serum calcium did not differ significantly from the normal pregnant group, but FECa was considerably lower and also reduced below the level in the nonpregnant control group. PTH was slightly lower during normal pregnancy than after delivery, but did not deviate significantly from the nonpregnant control group; in preeclampsia PTH did not deviate significantly from the levels in normal pregnancy. CT was the same in the third trimester of pregnancy in both groups. Changes in serum calcium and FECa were not correlated to PTH or CT. It is concluded that both normal pregnancy and preeclampsia are accompanied by considerable alterations in calcium metabolism, that PTH and CT in both groups are mainly unchanged and at nonpregnant level, and that the increase and decrease in renal calcium excretion in normal pregnancy and preeclampsia, respectively, may be attributed to changes in kidney function.

ISSN:0378-7346    

DOI:10.1159/000299073

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

Ultrasonic hysterography was performed in 104 patients, between the 2nd and 5th postpartum day. An unexpectedly high number of women (16%) exhibited an abnormal uterine configuration. The ultrasonic diagnoses were compared to the results of previous investigations of the uterine configuration, if available.

ISSN:0378-7346    

DOI:10.1159/000299074

出版商:S. Karger AG    

年代:1984

数据来源: Karger