ISSN:0378-7346    

DOI:10.1159/000280702

出版商:S. Karger AG    

年代:1899

数据来源: Karger

摘要:

To determine the placental clearance of lactate and bicarbonate in sheep, the fetal side of an isolated cotyledon and the umbilical circulation of the total placenta were artificially perfused. The release and uptake of lactate and bicarbonate by the perfusion fluid and the fetomaternal concentration differences of these substances were measured. From these data, the clearance of lactate and bicarbonate was determined to be 0.9 (SE = 0.2) ml/h/g of placental tissue. The production of lactate by the placenta was calculated to be about 30 μmol/min, the placental permeability of lactate was evaluated to be about 1.3 ml/h/g of placental tissue. These results indicate that fetal concentration changes of lactate and bicarbonate due to placental transfer occur with a half time of about 4 h. It is concluded that the lactate and bicarbonate permeability of the syndesmochorial placenta of the sheep is about 20 times smaller than the placental permeability of the hemochorial placenta of the guinea pig. It seems unjustified to draw any conclusions from experimental data obtained in the sheep placenta for the transplacental acid-base balance between mother and fetus in human beings.

ISSN:0378-7346    

DOI:10.1159/000299913

出版商:S. Karger AG    

年代:1979

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000280703

出版商:S. Karger AG    

年代:1899

数据来源: Karger

摘要:

Amylase concentration, L/S ratio and lecithin concentration were measured in 110 samples of amniotic fluid in 106 uneventful pregnancies. Amylase concentrations lower than 200 U/l corresponded significantly (p < 0.001) to a gestational age less than the 37th week as well as to a L/S ratio lower than 2 and to lecithin concentrations lower than 3.5 mg%. Furthermore, amylase values higher than 300 U/l corresponded significantly (p < 0.001) to a gestational age over the 37th week as well as to an L/S ratio over 2 and to lecithin concentrations over 3.5 mg%. On the other hand amylase concentrations ranging between 200 and 300 U/l failed to show any significant relationship neither to the age of gestation nor to the concentration of phospholipids. These findings show that the amylase test is a useful method for prediction of fetal maturity. Since the procedure of determination of the amylase concentration is very simple, cheap and rapid, the test can be used as screening method. However, when amylase concentrations are found to range between 200 and 300 U/l specific tests for assessment of fetal maturity have to be applied.

ISSN:0378-7346    

DOI:10.1159/000299914

出版商:S. Karger AG    

年代:1979

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000280704

出版商:S. Karger AG    

年代:1899

数据来源: Karger

摘要:

Within the last 3 years a prospective study on 70 pregnant women suffering from hypotension was carried out. In all these patients the endocrine placental function was examined regularly by measuring the HPL and E3 level in the maternal serum (from the 16th week of pregnancy onwards). In order to get information on the uteroplacental perfusion rate, placental flow measurements using radioisotopes were carried out. Whereas the endocrine parameters revealed no abnormality, the results of the flow measurements were significantly low in more than 80%. In 30 out of the total of 70 patients no medication was given and after termination of pregnancy the fetal outcome was investigated. The neonates of this group were significantly smaller than normal, the rate of dystrophy was considerably high. The other 40 women were subjected to a drug regimen. Depending on pressure values and type of complaints they were given a crystal suspension of deoxycorticosterone trimethylacetate intramuscularly. In this group of patients the placental perfusion rate improved significantly after medication, the fetal outcome did not differ in comparison to cases with normotension. In the light of our study we suggest that a maternal blood pressure of 110/65 and below has to be treated not only because of maternal indication, but as well because of the fetus’ sake.

ISSN:0378-7346    

DOI:10.1159/000299915

出版商:S. Karger AG    

年代:1979

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000280705

出版商:S. Karger AG    

年代:1899

数据来源: Karger

摘要:

The acute metabolic and circulatory effects of cigarette smoking (two cigarettes of a standard brand) in the last trimester of pregnancy were studied. 12 subjects, all of whom where hospitalized because of pregnancy complications, volunteered to participate in the investigation. A statistically significant immediate increment in the maternal heart rate, systolic and diastolic blood pressure, fetal heart rate, plasma glucose and plasma cyclic AMP was noted. Plasma glycerol, plasma insulin and blood lactate did not change significantly. 30 min after smoking there was a small but significant increase in plasma nonesterified fatty acids, plasma β-hydroxybutyrate and plasma C-peptide.

ISSN:0378-7346    

DOI:10.1159/000299916

出版商:S. Karger AG    

年代:1979

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000299917

出版商:S. Karger AG    

年代:1979

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000299918

出版商:S. Karger AG    

年代:1979

数据来源: Karger