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1. |
Results of the Use of a Pure Urinary FSH Stimulation Regime in Patients Unsuccessfully Treated with hMG in an in vitro Fertilization Program |
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Gynecologic and Obstetric Investigation,
Volume 28,
Issue 4,
1908,
Page 169-173
M. Grillo,
S. Buck,
I. Freys,
L. Mettler,
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摘要:
63 infertile patients who failed in achieving pregnancy for several cycles with human menopausal gonadotropin stimulation protocol in our in vitro fertilization program were subsequently treated with urinary FSH regime. In 25 of these patients, the leading diagnosis was an elevated basal LH/FSH ratio (i.e. above 2), 29 women had an irreparable tubal factor, 9 patients had endometriosis, and 21 couples suffered from an additional male factor. The FSH stimulation protocol was initiated on day 2 of the cycle, the highest doses were given on the first days and reduced thereafter. Hormone measurements concerning estradiol and LH were started on day 2 of the cycle, ultrasonic evaluation on day 7 of the cycle. After 48 pelviscopic follicle punctures and 39 embryotransfers 12 cases resulted in clinical pregnancies. One case terminated in a miscarriage and 2 pregnancies were of ectopic location.
ISSN:0378-7346
DOI:10.1159/000293571
出版商:S. Karger AG
年代:1989
数据来源: Karger
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2. |
Mode of Delivery and Lymphocyte β2-Adrenoceptor Density in Parturients and Newborns |
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Gynecologic and Obstetric Investigation,
Volume 28,
Issue 4,
1908,
Page 174-177
Markku Santala,
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摘要:
Twenty-six women with uncomplicated pregnancy at term were selected for the study. Nine had spontaneous vaginal delivery without medication, 8 elective caesarean section under epidural and 9 under general anaesthesia. The results clearly demonstrate that newborns have lower lymphocyte β2-adrenoceptor density than their mothers. In vaginally delivered newborns the lymphocyte β2-adrenoceptor density was 38%, in the caesarean section group with general anaesthesia 27%, and with epidural anaesthesia 22% lower than in the corresponding mother group. Vaginally delivered newborns have lower lymphocyte β2-adrenoceptor density than those delivered by caesarean section. A plausible explanation is the down-regulation of the β2-adrenoceptors during labour and delivery.
ISSN:0378-7346
DOI:10.1159/000293572
出版商:S. Karger AG
年代:1989
数据来源: Karger
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3. |
Fetal Demise Associated with Lupus Anticoagulant: Clinical Features and Results of Treatment |
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Gynecologic and Obstetric Investigation,
Volume 28,
Issue 4,
1908,
Page 178-184
H.J.A. Carp,
Y. Frenkel,
A. Many,
Y. Menashe,
S. Mashiach,
L. Nebel,
V. Toder,
D.M. Serr,
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摘要:
There are many reports in the literature associating lupus anticoagulant with fetal death. Successful pregnancies have been reported following suppression of the antibody by prednisone and the addition of antiaggre-gants and possibly anticoagulants. This report describes our experience treating such patients and the outcome of subsequent pregnancies. The results are less successful than the figures in the literature, 13 live births out of 27 pregnancies in 19 patients. This may be due to lupus anticoagulant being diagnosed as the cause for a wide variety of clinical presentations including habitual first trimester abortion, mid trimester fetal death, intrauterine growth retardation and placental dysfunction in the third trimester. Our experience shows that steroids and antiaggregants have a definite place in cases of second and third trimester fetal death and in cases of clinical systemic lupus erythematosus. However, lupus anticoagulant is one of a spectrum of autoantibodies whose pathophysiology has not been fully elucidated. It is questionable whether this regimen of treatment has a place in patients with no previous fetal loss or in cases of primary habitual abortion.
ISSN:0378-7346
DOI:10.1159/000293573
出版商:S. Karger AG
年代:1989
数据来源: Karger
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4. |
Fibronectin and Postpartum Infection in Rabbits: An Animal Model |
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Gynecologic and Obstetric Investigation,
Volume 28,
Issue 4,
1908,
Page 185-190
R.E. Bawdon,
A.M. Fiskin,
B.B. Little,
L.L. Davis,
G. Vergarra,
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摘要:
A rabbit model was explored in preliminary studies of uterine colonization and infection, following cesarean section (CS), by toxigenic Staphylococcus aureus (Harrisburg) and other bacterial species known to be isolated from traumatized human uteri; effects on host susceptibility of fibronectin prophylaxis were studied. Histological characteristics and plasma fibronectin levels were recorded in double-blinded studies of four groups of rabbits (55 total), all sacrificed 96 h after CS performed at term. Animals which were inoculated without fibronectin prophylaxis, showed stable or slightly elevated plasma fibronectin levels through 96 h. Rabbits inoculated with nontoxigenic S. aureus (Wiley) exhibited stable fibronectin levels and less microscopic evidence of infection. All inoculated animals were colonized, but those that received fibronectin cryoprecipitate intravenously at CS showed less microscopic evidence of infection. Fibronectin levels for rabbits scores as ‘seriously infected’ were nearly 1.5 times that of controls. This is in contrast to other clinical studies in which chronic infections and poor clinical outcome have been strongly correlated with decreased plasma fibronectin levels. Histochemical studies of antifibronectin binding suggested that less fibronectin is deposited throughout the endometrial stroma of animals that received fibronectin prior to bacterial challenge. An increased polymorphonuclear leukocytic reaction in the stroma near the incisions was observed in animals that received fibronectin prophylaxis, with or without bacterial challenge. This reaction may be characterized as an acute-phase reaction.
ISSN:0378-7346
DOI:10.1159/000293574
出版商:S. Karger AG
年代:1989
数据来源: Karger
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5. |
Rabbit Plasma Fibronectin Levels Associated withStaphylococcusaureusEnterotoxin B: An Acute-Phase Reaction |
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Gynecologic and Obstetric Investigation,
Volume 28,
Issue 4,
1908,
Page 191-194
Roger E. Bawdon,
Lowell E. Davis,
Bertis B. Little,
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摘要:
Variation in fibronectin (Fn) levels and white blood cell counts (WBC) following staphylococcal enterotoxin B (SEB) or SEB + cryoprecipitate containing Fn challenge was studied in New Zealand white rabbits. Increased plasma Fn levels were observed 2 h after the intravenous injection of SEB and peaked at 48–72 h (from a mean level 194.6 ± 4.5 µg/ml prechallenge Fn level to a 72-hour postchallenge mean level of 407.9 ± 25.4 µg/ml). Fn levels then decreased over the succeeding 5 days to approximately prechallenge levels. The total WBC count decreased by 88% within 2 h after the SEB injection. A slow increase in circulatory WBC was observed over the next 24 h. SEB caused an increase in plasma Fn levels and decreased WBC counts with lymphopenia that was followed by a normal lymphocyte count within 5 days. These data suggest that an acute-phase reaction was induced by interleukin-1. Fn prophylaxis provided no change in clinical signs when given at the time of SEB inje
ISSN:0378-7346
DOI:10.1159/000293575
出版商:S. Karger AG
年代:1989
数据来源: Karger
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6. |
Antenatal Measurement of Scapula Length Using Ultrasound |
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Gynecologic and Obstetric Investigation,
Volume 28,
Issue 4,
1908,
Page 195-197
Fuminori Murao,
Toshihiko Shibukawa,
Osamu Takamiya,
Kazuhiko Yamamoto,
Kiyoshi Hasegawa,
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摘要:
In 76 fetuses from 14 weeks of gestation through to term, measurements of the scapula were made using ultrasound. Statistical analysis of the results revealed a highly significant correlation between scapula measurements and gestational age, biparietal diameter, fetal femur length and fetal abdominal circumference (r = 0.93, 0.91, 0.95, and 0.91, respectively). In particular, values related to length of the scapula were highly correlated with femur length. These findings show that this measurement is useful as an adjunct to assessing development as well as growth of the femur and dating parameters of the fetus in utero.
ISSN:0378-7346
DOI:10.1159/000293576
出版商:S. Karger AG
年代:1989
数据来源: Karger
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7. |
Ultrasonic Evaluation of Liver Development in the Fetus in utero |
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Gynecologic and Obstetric Investigation,
Volume 28,
Issue 4,
1908,
Page 198-201
Fuminori Murao,
Daisaku Senoh,
Osamu Takamiya,
Kazuhiko Yamamoto,
Kiyoshi Hasegawa,
Manabu Kitao,
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摘要:
A total of 573 measurements of the human fetal liver size were made from 18 to 41 weeks gestation. The right hepatic lobe increased linearly throughout gestation, whereas the left lobe increased linearly until approximately 32 weeks gestation, after which a slight slowing was observed. There was a highly significant correlation between both hepatic lobe sizes and gestational age (r = 0.94, r = 0.88; p < 0.01, p < 0.001).
ISSN:0378-7346
DOI:10.1159/000293577
出版商:S. Karger AG
年代:1989
数据来源: Karger
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8. |
Incidence of Adhesions in the True Pelvis after Pelviscopic Operative Treatment of Tubal Pregnancy |
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Gynecologic and Obstetric Investigation,
Volume 28,
Issue 4,
1908,
Page 202-204
H. Mecke,
K. Semm,
I. Freys,
Ch. Argiriou,
H.-J. Gent,
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摘要:
33 patients with tubal pregnancies, who had been treated by pelviscopy with organ preservation between 1978 until the beginning of 1988 have had follow-up examinations from within 4 months to 2 years after their first operation. In 15 (45%) of these 33 patients we found adhesions in the true pelvis on initial pelviscopy; these adhesions were lysed in all cases. During a second inspection of the abdominal cavity – either by laparotomy (Cesarean section; 4 patients) or by repelviscopy (29 patients) – mainly avascular, filmy adhesions on one or both adnexae were found in 17 cases (52%). The pelviscopic treatment of ectopic pregnancy does not completely prevent the development of postoperative adhesions. The concomitant pelviscopic adhesiolysis during the treatment of ectopic pregnancy reduces the degree of severity of the recurring adhesions.
ISSN:0378-7346
DOI:10.1159/000293578
出版商:S. Karger AG
年代:1989
数据来源: Karger
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9. |
Naproxen Sodium in the Treatment of Premenstrual Symptoms |
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Gynecologic and Obstetric Investigation,
Volume 28,
Issue 4,
1908,
Page 205-208
F. Facchinetti,
L. Fioroni,
G. Sances,
G. Romano,
G. Nappi,
A.R. Genazzani,
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摘要:
The prostaglandin system is thought to play a role in the etiology of the premenstrual syndrome. Many authors describe that prostaglandins are involved in both central and peripheral symptoms. To test this hypothesis, we studied the effects of naproxen sodium treatment (550 mg twice daily, from day –7, in relation to next menses, to the 4th day of the cycle) in 34 patients suffering from premenstrual syndrome. Six cases dropped out. Fourteen women were given placebo for the first three cycles of the trial, followed by active drug. The other 14 patients were given naproxen sodium, beginning from the first cycle. In order to evaluate premenstrual symptoms, the Moos menstrual distress questionnaire was prospectively applied during the 2-month run-in period and at the 3rd and 6th cycles of treatment. During our double-blind naproxen sodium study, both menstrual and premenstrual ‘pain’ decreased during active drug treatment, while placebo was ineffective. We also obtained a significant improvement of premenstrual ‘behavioral changes’ which is probably related to the relief of painful symptomatology. In conclusion, this study indicates that naproxen sodium is a useful and safe drug in the treatment of premenstrual and menstrual pain related symptoms.
ISSN:0378-7346
DOI:10.1159/000293579
出版商:S. Karger AG
年代:1989
数据来源: Karger
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10. |
Ultrasound Assessment of the Bladder Volume after Anterior Colporrhaphy |
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Gynecologic and Obstetric Investigation,
Volume 28,
Issue 4,
1908,
Page 209-211
Y. Paltieli,
S. Degani,
A. Aharoni,
I. Shapiro,
A. Reiter,
M. Scharf,
A. Weiss,
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摘要:
In 40 gynecological patients 44 different determinations of the bladder volume were made using ultrasonic methods. The product of bladder depth, height, and width, as determined from transverse and sagittal scans, showed the best correlation with the bladder volume measured by urethral catheter (r = 0.981). For 73% of the measurements the error was under 20% when the true bladder volume was > 100 cm3. This method gives a reasonable assessment of the bladder residual volume. It is quick, safe, and repeatable and, therefore, useful in postoperative clinical practice.
ISSN:0378-7346
DOI:10.1159/000293580
出版商:S. Karger AG
年代:1989
数据来源: Karger
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