摘要:

Schwangerschaftsprotein 1 (SP1) values in serum and urine were compared. The first appearance of the protein in urine happens 9–17 days after the first SP1(-positive serum, i.e., about 9 days after the first missed period. Urinary SP1 values up to 6 weeks after LMP do not correlate with gestational age as do serum values, but towards the end of the first trimester this correlation becomes almost as good as the one obtained with serum. The urinary SP1 concentration of SP1 fluctuates around 2.3% of the serum concentration throughout pregnancy.

ISSN:0378-7346    

DOI:10.1159/000298939

出版商:S. Karger AG    

年代:1986

数据来源: Karger

摘要:

The beneficial effects of the oral application of zinc aspartate in pregnancy is investigated in a randomly selected study group of 179 patients and a control group of 345 patients. This study confirms the prophylactic effectiveness of zinc replacement in reducing the overall complication rate for both mother and fetus and in particular for large-for-date and small-for-date infants. The therapy is well tolerated and accepted by the patients and causes no side effects. The results are in line with those of other working groups reporting on zinc as an important element with protective effects on fetal growth and development in pregnancy.

ISSN:0378-7346    

DOI:10.1159/000298940

出版商:S. Karger AG    

年代:1986

数据来源: Karger

摘要:

The effects of therapeutic concentrations of antihypertensive drugs on catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO) activities in term placental explants were studied. The enzyme activities were measured in tissue fractions using radioen-zymatic techniques. At 6 h the incubation COMT activity increased significantly following exposure to verapamil and hydralazine, while exposure to alpha methyldopa caused a significant suppression of the enzyme. At 24 h exposure to hydralazine significantly suppressed the COMT activity. By 6 h the MAO activity was significantly suppressed by verapamil. MgSO4 and propranolol had no effect on the activities of COMT and MAO at 6 and 24 h. These results suggest that COMT and MAO activities in the placenta can be modulated by antihypertensive drugs and, therefore, these drugs might affect local catechol metabolism.

ISSN:0378-7346    

DOI:10.1159/000298941

出版商:S. Karger AG    

年代:1986

数据来源: Karger

摘要:

In vitro effects of ethanol on human umbilical artery and vein were studied. Ethanol (0.5–2.0%) elicited a dose-dependent contractile response both in the umbilical arterial and venous strips in Krebs’ and Ca2+-free Krebs’ solution. In umbilical artery, but not in vein, ethanol shifted the Ca2+-induced dose-response curves to the right in a parallel manner along with a significant reduction in K+-depolarized maximal tension. These result demonstrate that ethanol can elicit a potent contractile response both in human umbilical arteries and veins and could aid in explaining why ethanol can induce the fetal alcohol syndrome.

ISSN:0378-7346    

DOI:10.1159/000298942

出版商:S. Karger AG    

年代:1986

数据来源: Karger

摘要:

The present study uses an in vitro model to test the influence of hormones on the replication and reactivation of cytomegalovirus (CMV) in endometrial tissue culture. Infection of epithelial cells of the endometrium with CMV in the presence of a high concentration of estradiol resulted in only a slightly higher yield of infectious virus. Progesterone did not cause any effect on viral replication. Arrest of CMV replication was achieved by reduction of the pH of the incubation medium. No infectious virus was detectable after incubation of infected cultures at pH 5.8. In the above-described conditions following the arrest of CMV replication by low pH, estradiol treatment was capable of reactivating the virus. The possibility that the increase in CMV infection observed in pregnancy is caused by reactivation of latent virus provoked by hormonal factors will be discussed.

ISSN:0378-7346    

DOI:10.1159/000298943

出版商:S. Karger AG    

年代:1986

数据来源: Karger

摘要:

A prospective, randomized, nonblind study was performed to compare the efficacy of a 7-day vaginal regimen with 500 mg metronidazole (Flagyl®) once a day and that of oral treatment with 400 mg metronidazole twice daily for 7 days in the treatment of nonspecific bacterial vaginosis. No treatment was given to the sexual partners and there was no restriction of sexual intercourse. 38 women completed the study and at follow-up after 4 weeks, women receiving vaginal therapy had a cure rate of 79% compared with 74% in the women on oral therapy. Cure rates were lower among users of an intrauterine contraceptive device (57 versus 88% among nonusers). The occurrence of lactate-producing bacteria (lacto-bacilli and aerobic streptococci) in the vagina was significantly higher in women after vaginal compared with oral therapy. Gardnerella vaginlis was isolated in 58% of the women after vaginal and in 44% of the women after oral treatment. It is concluded that vaginal application of 500 mg metronidazole daily for 7 days is equally effective as oral administration in the treatment of bacterial vaginosis.

ISSN:0378-7346    

DOI:10.1159/000298944

出版商:S. Karger AG    

年代:1986

数据来源: Karger

摘要:

Clinical and experimental observations suggest that oestrogens may influence immune reactivity. The oestrogen-binding properties of the human thymus were studied by the use of an aqueous two-phase separation technique. A specific, high-affinity and low-capacity binding was found in 9 out of 10 thymic tissue samples obtained from children and adults of both sexes, their ages ranging from 1 to 42 years. The association constant ( ± SD) for the oestradiol binding in human thymus was 3.7 ± 1.4 × 109M-1 and was in the same range as the receptor binding in the human uterus. The steroid specificity was found to differ from the classical oestrogen receptor. The concentration of oestrogen-binding sites ( ± SD) was 182 ± 181 fmol/mg protein and was higher than the receptor concentration of the uterus. According to histochemical analyses the binding is located in the reticulo-epithelial stroma rather than the thymocytes. Data suggest that the human thymus is a target organ for oestrogens which may influence lymphocyte function during therapy.

ISSN:0378-7346    

DOI:10.1159/000298946

出版商:S. Karger AG    

年代:1986

数据来源: Karger

摘要:

Binding of wheat germ agglutinin (WGA) and peanut agglutinin (PNA) was studied cytochemically in 43 cervical specimens covering a range of lesions from moderate atypia to invasive carcinoma. Normal squamous epithelium showed weak binding of WGA and negative reaction with PNA. Atypical squamous epithelium was characterized by moderate binding of WGA and PNA, while malignant lesions demonstrated strong affinity to both lectins. In adenocarcinoma in situ, WGA and PNA binding was reduced by comparison with normal glandular epithelium, that was strongly positive.

ISSN:0378-7346    

DOI:10.1159/000298947

出版商:S. Karger AG    

年代:1986

数据来源: Karger

摘要:

The expression of the lacto-N-fucopentaose III (LNF III) epitope by tumor cells of the gastrointestinal tract and ovary has been observed in tissue sections with the use of the murine monoclonal antibody GA 29–1. The presence of the LNF III epitope in the circulation of patients with colorectal cancer has also been reported. In this preliminary study, we describe the presence of LNF III activity in the serum of patients with adenocarcinoma of the ovary. Twelve of 18 (66%) patients with stage I-IV disease demonstrated high reactivity to the GA 29–1 monoclonal antibody. This serum reactivity was independent of disease stage and histologic cell type. In contrast, only 1 of 6 control patients demonstrated a false-positive level of reactivity to GA 29–1. These preliminary results suggest that LNF III warrants further study of its potential application as a serum tumor marker test in patients with adenocarcinoma of the ovary.

ISSN:0378-7346    

DOI:10.1159/000298948

出版商:S. Karger AG    

年代:1986

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000285480

出版商:S. Karger AG    

年代:1905

数据来源: Karger