摘要:

A 28-year-old woman with well-developed female secondary sexual characteristics, secondary amenorrhea, short stature and a few somatic anomalies of streak gonad syndrome who had bilateral ‘burnt out’ gonadoblastoma associated with 45, X karyotype is reported. Although the exact source of steroid production in the present case could not be defined, it seems probable that the tumor once secreted steroid hormones which were responsible for the development of the female secondary sexual characteristics. At the time of diagnosis there was no evidence of hormonal activity of the tumor. Cases of gonadoblastoma without Y chromosome are reviewed. The diagnostic difficulties encountered in patients with gonadoblastoma not associated with Y chromosome are discussed.

ISSN:0378-7346    

DOI:10.1159/000293544

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

The fatty acid composition in cervical mucus was determined in 37 pregnant and 17 nonpregnant women using gas liquid chromatography. In both groups palmitic acid (16:0) and oleic acid (18:1) were the predominant acids comprising more than half of the total amount. Compared to nonpregnant controls, pregnant women had markedly elevated levels of oleic acid (18:1), while mean levels of myristic acid (14:0) and stearic acid (18:0) were significantly lower. These pregnancy-induced changes in fatty acid pattern could not be ascribed to the increased viscosity of cervical mucus. Only minor differences in fatty acid pattern were found between women in first trimester and at term. In contrast to nonpregnant controls, a significant negative correlation between levels of myristic acid (14:0) and docosahexaenoic acid (22:6) was found in pregnant women, indicating a redistribution of these two fatty acids during pregnancy. The present study demonstrates that pregnancy alters the fatty acid composition of cervical mucus lecithin, and that the characteristic changes are present before the 10th gestational week.

ISSN:0378-7346    

DOI:10.1159/000293545

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

Mechanical stretching increases synthesis and release of prostaglandin E2 (PGE2) in cultured amnion cells. The maximum level of PGE2 in stretched amnion cells is three times higher than that in nonstretched amnion cells. The maximum level of PGE2 in stretched cell medium is nine times higher than the maximal level of PGE2 in nonstretched cell medium. 3H-thymidine incorporation into DNA is 211 ± 25 cpm/105 cells in nonstretched groups; that in stretched groups is 582 ± 94 cpm/105 cells. There is a significant difference between the two groups. These results suggest that stretch stimulation facilitates prostaglandin production in fetal membranes, which may contribute to uterine contraction in labor.

ISSN:0378-7346    

DOI:10.1159/000293546

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

Apolipoproteins were determined in 50 human amniotic fluids obtained by amniocentesis during weeks 16 and 22 (n = 26) or 33 and 41 (n = 24) of gestation. Whereas apo A-I, A-II, A-IV, and E were identified at levels of 1 0.7, 0.8 and 1% of normal human adult plasma, respectively, apo B levels were only 0.04% of plasma concentration and apo C-III levels were below the detection limits of the assay. Amniotic fluid levels of apo A-II, A-IV and E did not differ between early and late stages of pregnancy, but levels of apo B decreased and apo A-I increased significantly in late pregnancy. Isofocusing showed apo A-I, A-II and A-IV in identical positions as compared to human adult plasma. Furthermore the known genetic polymorphism of apo A-IV was detectable. Individuals heterozygous for the variant form apo A-IV-2, showing the phenotype apo A-IV (2–1), had significantly higher levels of apo A-I and A-II as compared to the common phenotype apo A-IV (1–1). We conclude that human amniotic fluid contains the major plasma apolipoproteins at about 1% of plasma levels with the exception of apo B which shows a level at an order of magnitude less than high-density lipoprotein apoproteins in comparison to their plasma counterparts.

ISSN:0378-7346    

DOI:10.1159/000293547

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

Changes in serum levels of calcium, magnesium, cAMP and monoamine oxidase (MAO) activity throughout pregnancy and during prolonged treatment for preterm labor with ritodrine were studied. cAMP levels in the third trimester of pregnancy were found to be significantly high and postpartum MAO activity was significantly low. In cases of preterm labor, serum levels of calcium, magnesium and MAO activity were significantly low during the initial stage of ritodrine administration, then recovered after more than 1 week of treatment despite the fact that given doses and serum levels of ritodrine remained constant and that the serum level of cAMP was still high. These results suggested that a control mechanism for MAO activity during pregnancy might exist due to an increase in catecholamine and that the β2-effect of ritodrine induced a lowering in serum calcium and magnesium levels. However, some homeostatic mechanism to regulate the ions might come into play later on the mechanism of down-regulation of ritodrine.

ISSN:0378-7346    

DOI:10.1159/000293548

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

The hydroxyproline content of the amnion and the umbilical vessels obtained from cases in which the fetal membranes were instrumentally or prematurely ruptured was assayed. Hydroxyproline concentration (in μg/mg) in the latter group was 23.76, 16.79 and 17.86 in the amnion, artery and vein, whereas in the former the corresponding values were 42.20, 26.61 and 32.48. These results show that, in addition to a decrease in the amnion, hydroxyproline is lowered also in the umbilical vessels, suggesting that the reduction in the collagen in the fetal membranes is probably a particular manifestation of a general metabolic deficiency.

ISSN:0378-7346    

DOI:10.1159/000293549

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

In 32 fetuses from 37 to 41 weeks’ gestation, motorical and heart rate response time, as well as the influence of arousal state on that time were tested. Motorical response time was defined as the time from external stimulus to fetal movement. Heart rate response time was defined as the time from stimulus to the increase in baseline of 15 beats/min. Wide low frequent sound was used as external stimulus. No correlation could be found between motoric and heart rate response time (R = 0.26652). Among the various arousal states the lower arousal state had a significantly longer motorical and heart rate response time.

ISSN:0378-7346    

DOI:10.1159/000293550

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

The uterus-relaxant effect of diltiazem, a recently developed calcium antagonist, was investigated in vitro. 24 myometrial strips dissected from the lower uterine segment during cesarean section showed a statistically highly significant (p < 0.001) decrease of their spontaneous contractility in the presence of Diltiazem 10––6M: 82% after 10 min, 100% after 20 and 100% after 60 min (median values). Diltiazem, which is considered to be the most balanced calcium antagonist as far as cardiovascular side effects are concerned, could be of considerable interest also for clinical use.

ISSN:0378-7346    

DOI:10.1159/000293551

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

Six women with polycystic ovarian syndrome were treated with a gonadotropin-releasing hormone agonist prior to ovulation induction with gonadotropins. Buserelin nasal spray (600 μg/day) was given for 6 weeks. There was a gradual and significant decrease in the level of luteinizing hormone (LH) during the treatment period. No change was observed in the level of follicle-stimulating hormone. The estradiol, estrone, testosterone and androstenedione levels decreased significantly. No reduction was seen in the DHEAS level. After 4 weeks of treatment LH had reached postmenopausal levels, and testosterone and androstenedione were within the normal range. It is concluded that 4 weeks’ treatment with 600 μg buserelin intranasally per day is sufficient to normalize the ovarian androgen production in polycystic ovarian syndrome prior to gonadotropin stimulation and to reduce the LH level avoiding premature luteinization or spontaneous LH surge.

ISSN:0378-7346    

DOI:10.1159/000293552

出版商:S. Karger AG    

年代:1989

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000293553

出版商:S. Karger AG    

年代:1989

数据来源: Karger