摘要:

A group of 65 IUD users was studied during a period of 165 years of use, with a mean of 2.6 ± 1.7 years per woman. The main complaint which differed significantly from the 120 controls was the occurrence of spotting in 33.8% of IUD users. Normal endometrial mucosae were found in 36.9% of IUD users and 38.7% of controls. Chronic endometritis was evidenced in 35.4% of IUD users versus 12.5% of controls; the former were asymptomatic in 25.0% of the cases. 39.1 % of them had normal endometrial synchrony. Chronic endometritis occurred 2.2 ± 1.3 years after insertion of the device. Endometritis was always symptomatic in controls; only 13.3% of them exhibited endometrial synchrony. The fundamental mechanism(s) responsible for the contraceptive efficiency of intrauterine contraceptive devices (IUD) remains a subject of controversy and a field of investigation. The most recent studies are essentially directed towards the biochemical analysis of uterine fluid [1]. Nevertheless, the presence of an inflammatory process, either morphologically or biochemically detectable, seems to be one of the fundamental modifications induced by the IUD. Since a certain reluctance to use IUDs has been observed in some countries, which has been ascribed mainly to contradictory reports on the risk of pelvic inflammatory disease (PID) in women wearing such devices [2], we found it interesting to intend to objectivate and reevaluate the influence of IUD on chronic aspecific endometritis, a possible precursor state of salpingitis and PID.

ISSN:0378-7346    

DOI:10.1159/000299241

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

In the present report, the techniques of isolation and morphological and functional characteristics of a subpopulation of human endometrial stromal cells are described. The data obtained point that these cells are macrophages, and that the uterine mucosa can be considered as a hormone-dependent territory of the monocyte-histiocytic system, since these cells can only be demonstrable during the proliferative or secretory phases of the uterine cycle, but not in atrophic, postmenopausal endometria.

ISSN:0378-7346    

DOI:10.1159/000299242

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

Simultaneous determinations of LDH activity in the vaginal epithelium and the maturation index of the vaginal smear were performed for 7 postmenopausal women receiving estrogen therapy and for 4 premenopausal women. Of the premenopausal women, 1 was receiving cyclic estradiol valerate-levo-norgestrel therapy; the others were menstruating regularly and had no hormone therapy. A good correlation was found between the strength of the estrogen therapy and LDH activity. In general, a positive correlation was found between a high level of LDH activity and a shift to the right in the maturation index. Where inflammation occurred, the LDH activity reflected the estrogen effect, whereas the maturation index did not do so.

ISSN:0378-7346    

DOI:10.1159/000299243

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

In 4 patients with hypothalamic amenorrhea, the pituitary responsiveness to an intravenous challenge of 20 μg synthetic gonadotropin-releasing hormone (GnRH) was evaluated before and following a 3-days treatment course with GnRH (100 μg/per day i.m.) or ethinyl estradiol, (100 μg/day orally). The amenorrheic patients all had normal or reduced levels of serum gonadotropins, no evidence of galactorrhea and no other endocrine abnormality. Following GnRH treatment basal luteinizing hormone levels as well as the luteinizing hormone and follicle-stimulating hormone responses to GnRH were markedly reduced when compared with responses to GnRH before the treatment. Responses to GnRH were significantly augmented after treatment with estrogens. In patients with previous treatment with GnRH the augmented estrogen-induced LH response to GnRH was abolished. These preliminary results support the pathophysiological concept that in amenorrheic patients with hypothalamic dysfunction long-term administration of GnRH does not result in an improvement but rather in a deterioration of pituitary gonadotropic function.

ISSN:0378-7346    

DOI:10.1159/000299244

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

In a retrospective study of 150 pregnant women with high or low serum HCG levels at the time they sought acute advice at the ward, two categories of women were found: a majority (n = 111) who had abdominal pain and/or vaginal bleeding, and a minor group (n = 39) who worried about their condition but were otherwise symptom free. The underlying reason for the difference in clinical outcome amongst ‘bleeding’ and ‘concern’ women with both high and low HCG serum values are discussed. It is concluded that women with abnormal HCG levels in early pregnancy deserved close attention in the 3rd trimester.

ISSN:0378-7346    

DOI:10.1159/000299245

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

For the clinical evaluation of the uteroplacental blood flow the radioactivity curve over the placenta is recorded by means of a gamma scintillation camera and is calculated by iterative regression method. The flow curves were attributable with good clinical relevance to 3 perfusion types: perfusion type I indicates unimpaired uteroplacental flow. Type II is a transitional type to the pathological type III. Over two-thirds of the type III cases gave births to babies with signs of moderate to severe malnutrition and in 1 case an intrauterine death occurred.

ISSN:0378-7346    

DOI:10.1159/000299246

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

A sensitive and specific radioimmunoassay method was developed for the determination of oxytocin in human serum. Serum oxytocin levels were assayed in five healthy male volunteers and four healthy non pregnant female volunteers after rapid intravenous injection of 2 U synthetic oxytocin. Peak oxytocin levels were found at 30 s after intravenous administration. The half-life (T½) of oxytocin was 6 min 22 s in male and 6 min 53 s in female serum.

ISSN:0378-7346    

DOI:10.1159/000299248

出版商:S. Karger AG    

年代:1983

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000299250

出版商:S. Karger AG    

年代:1983

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000283518

出版商:S. Karger AG    

年代:1902

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000283519

出版商:S. Karger AG    

年代:1902

数据来源: Karger