摘要:

Pathologic material was reviewed and survival data were obtained on 182 of the endometrial cancer patients reported in our previous study (1975) to compare histopathologic characteristics and clinical behavior (survival) between endometrial adenocarcinoma in estrogen users and nonusers. In addition, relative risk estimates of estrogen-associated endometrial carcinoma were calculated from review results. This work identifies estrogen users as having a significantly higher frequency of low-grade tumor with an associated improved survival even when numerous clinical parameters are taken into account. Other histologic or clinical characteristics of the disease did not relate significantly to estrogen use after taking account of histologic grade. The marked increase in endometrial cancer risk among estrogen users was confirmed by the pathology review (relative risk 6.44) and is evident even when attention is restricted to diesease that has invaded the myometrium (relative risk 6.09).

ISSN:0378-7346    

DOI:10.1159/000299600

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

Oviduct fluid, collected from 65 mature, female rabbits in estrus and in which a modified copper intrauterine device (IUD) was introduced by laparotomy in one of the uterine horns, was examined for chemical composition. No differences were noted for sodium, potassium, calcium, chloride and bicarbonate between the two sides. The copper content was found to be significantly higher in the IUD side (12.80 ± 3.01 μg/l00 ml), as compared to the control side (9.0 ± 1.0 μg/l00 ml), the toxicity of which, to blastocyst development, has been reported in some cases. Total protein in the experimental side was significantly higher (258.52 ± 36.22 mg < 100 ml) than in the control side (156.67 ± 26.45 mg/l00 ml). The same was found for sialic acid, 5.30 ± 0,62 μg/ml, compared to 3.66 ± 0.27 μg/ml, suggesting that a part of the increased protein can be ascribed to glycoprotein. Oviduct fluid glucose was found to be lower in the copper IUD side than in the control side (10.5 ± 0.2 vs. 17.7 ± 0.3 mg/l00 ml). These findings may be explained on the basis of an inflammatory process, taking place in the side of the copper IUD, and should be used with cautiousness in adolescent, and nulligravidae women.

ISSN:0378-7346    

DOI:10.1159/000299601

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

The effects of glycine on serum gonadotropins and estradiol (E2) and on concentrations of free amino acids in the middle hypothalamus have been studied in diestrus-1 rats. 20 min after intraperitoneal administration, glycine in doses of 50 and 100 mg had no significant effect on serum luteinizing hormone (LH) levels, but 200 mg significantly elevated serum LH levels. Glycine in doses of 50–200 mg had no effect on serum follicle-stimulating hormone levels at 20 min after intraperitoneal injection. 200 mg of glycine significantly elevated serum LH levels at 20 and 50 min and serum E2 levels at 50 and 80 min after intraperitoneal injection. The effects were maximal at 20 min after injection for LH and at 50 min after injection for E2. 20 min after intraperitoneal injection, 200 mg of glycine significantly increased the concentration of glycine in the middle hypothalamus, but had no effect on the concentrations of the other free acidic and neutral amino acids in the middle hypothalamus. These results suggest that glycine may play a role in the neural regulation of LH secretion.

ISSN:0378-7346    

DOI:10.1159/000299602

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

153 oral prostaglandin E2 (PGE2) inductions of labour were compared with 172 inductions with oxytocin. Details of these inductions are presented. After review of the data we assumed that induction of labour with oral PGE2 is less hazardous to mother or infant than with oxytocin. The similarity between the contractions of spontaneous labour and those labours produced by PGE2 is represented by the caesarean section rate in cases of elective induction. The operative delivery rate in the oxytocin-treated group was significantly higher. The need for close observation of the progress of labour during PGE2 inductions is emphasized.

ISSN:0378-7346    

DOI:10.1159/000299603

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

A new prostaglandin E2 derivative (Sulprostone) was given extra-amniotically to 17 healthy women, who were 7–8 weeks pregnant, in order to assess the plasma profile of HCG, 17β-estradiol (E2), and progesterone and to evaluate the effectiveness and overall acceptability of the method in relation to different dose levels. On the lowest dose level (5 μg) only 3 of 7 patients aborted within a 3– to 6–day period. At higher dose levels (10 and 15 μg, respectively) 9 out of 10 women exhibited clinical evidence of an abortion. In the group who aborted, E2, progesterone, and HCG decreased continuously, whereas in the nonabortion group decreased levels were found 3 and 6 h after administration of the drug, but already after 24 h the values had again increased. Practically all treated women experienced lower abdominal discomfort, 7 (41 %) reported the pains being severe. Vomiting and/or diarrhea occurred in 4 patients (24%). Similarly to other hitherto tested prostaglandins in humans, this new analogue exhibits its effect primarily through direct stimulatory effect on the uterine smooth muscle, resulting in subsequent decline in the concentrations of HCG, E2, and progesterone. In the group of successful inductions the decrease of the HCG concentration was close the half-time of HCG, indicating a permanent damage to the placenta. Despite the high success rate at a dose of 10 μg or more, the side effects, mainly abdominal cramps, were too severe to make this method feasible for the induction of early abortion when comparing to the available routine procedure of rapid vacuum curettage used on an outpatients basis.

ISSN:0378-7346    

DOI:10.1159/000299604

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

A continuous study to determine blood pressure and pressor response to angiotensin II (A-2) during pregnancy and postpartum was performed in a chronic rabbit preparation. The resting blood pressure during pregnancy was found to be lower than that in the postpartum period. Pressor response to A-2 was diminished during pregnancy and during nursing, but in the absence of nursing, this response returned to normal values by 1 week postpartum. Inhibition of prostaglandin synthetase caused a significant increase in the pressor response to A-2 during gestation, but did not change the resting blood pressure either before or after delivery. The results are discussed in light of previous animal and human studies, and factors which could affect vascular reactivity during gestation and nursing are analyzed.

ISSN:0378-7346    

DOI:10.1159/000299605

出版商:S. Karger AG    

年代:1981

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000299606

出版商:S. Karger AG    

年代:1981

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000299607

出版商:S. Karger AG    

年代:1981

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000281632

出版商:S. Karger AG    

年代:1900

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000281633

出版商:S. Karger AG    

年代:1900

数据来源: Karger