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1. |
Effect of Protein Synthesis Inhibitors and Metabolic Blockers on the Production of Placental Proteins by the in vitro Perfused Human Placenta |
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Gynecologic and Obstetric Investigation,
Volume 25,
Issue 3,
1988,
Page 145-151
N.A. Bersinger,
A. Malek,
B. Benz,
P.J. Keller,
H. Schneider,
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摘要:
The capacity of the freshly delivered human term placenta to produce and release placental proteins during in vitro dual perfusion was investigated. The organ was perfused in separate closed circulations and aliquots of medium were taken at regular intervals from both maternal and fetal circuits. The placental proteins human chorionic gonadotrophin (HCG), human placental lactogen (HPL), pregnancy-specific β1-glycoprotein (SP1), and pregnancy-associated plasma protein A (PAPP-A) were quantified in these media as well as in the placental tissue before and after the perfusion. It was found that the four above-mentioned proteins were synthesised during the perfusion interval (90 min to 3 h) while pregnancy-associated α2-glycoprotein and prolactin were only washed out. The mean production of HCG, HPL, SP1, and PAPP-A was decreased when either cycloheximide, puromycin, iodoacetic acid, or 2,4-dinitrophenol had been added to the perfusing medium. Amongst these four antimetabolites iodoacetic acid most severely affected both the total release and net synthesis. It is concluded that the above four proteins are synthesised de novo by the perfused placenta in the absence of maternal tissue and that this synthesis is energy-dependen
ISSN:0378-7346
DOI:10.1159/000293763
出版商:S. Karger AG
年代:1988
数据来源: Karger
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2. |
Interexaminer Variability of Fetal Doppler Velocity Waveforms |
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Gynecologic and Obstetric Investigation,
Volume 25,
Issue 3,
1988,
Page 152-157
S.J. Nienhuis,
J.M.G. van Vugt,
H.J. Hoogland,
C.J. Ruissen,
J. de Haan,
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摘要:
A study was made of the interexaminer variability of Doppler velocity waveform determinations of the fetal circulation. Three investigators recorded Doppler ultrasound tracings of the blood velocity in the fetal thoracic and abdominal aorta and umbilical artery in 23 uncomplicated pregnancies. Of these recordings, a hard copy was made, and the pulsatility indices were computed. An analysis of variance was performed and the reliability calculated. The interexaminer variability was nonsignificant in measurements of the three blood vessels under examination. Both thoracic and abdominal aorta measurements showed poor reliability (intraclass correlation coefficient of reliability 0.30 and 0.19, respectively) due to high random errors. Umbilical artery measurements showed a better reliability (intraclass correlation coefficient of reliability 0.61), and, therefore, these hold the greatest clinical applicability.
ISSN:0378-7346
DOI:10.1159/000293764
出版商:S. Karger AG
年代:1988
数据来源: Karger
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3. |
Longitudinal Study of Plasma Lipids and Lipoprotein Cholesterol in Normal Pregnancy and Puerperium |
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Gynecologic and Obstetric Investigation,
Volume 25,
Issue 3,
1988,
Page 158-164
Dolores M. Jimenez,
Miguel Pocovi,
Juan Ramon-Cajal,
Manuel A. Romero,
Heraclio Martinez,
Francisco Grande,
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摘要:
Plasma lipids and lipoprotein cholesterol distribution were measured in 60 normal pregnancies studied longitudinally at 12, 20, 28, and 36 weeks of gestation and 3 and 40 days postpartum. Total cholesterol, unesterified cholesterol, phospholipids, triglycerides and cholesterol in low- and very-low-density lipoproteins rose progressively during pregnancy. Maximal values were reached at 36 weeks for total cholesterol, unesterified cholesterol and low-density lipoprotein cholesterol and at partum for triglycerides, very-low-density lipoprotein cholesterol and phospholipids. High-density lipoprotein cholesterol was hardly affected by pregnancy. During the second half of pregnancy and postpartum period, high-density lipoprotein cholesterol was consistently and negatively correlated with triglycerides and very-low-density lipoprotein cholesterol. In each period studied total cholesterol showed very high positive correlation with low-density lipoprotein cholesterol but a weak correlation with high-density lipoprotein cholesterol.
ISSN:0378-7346
DOI:10.1159/000293765
出版商:S. Karger AG
年代:1988
数据来源: Karger
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4. |
NK Cell Activity and Estrogen Hormone Levels during Normal Human Pregnancy |
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Gynecologic and Obstetric Investigation,
Volume 25,
Issue 3,
1988,
Page 165-172
Jelka Gabrilovac,
Josip Zadjelović,
Maja Osmak,
Ernest Suchanek,
Željko Županović,
Milivoj Boranić,
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摘要:
NK cell activity was determined in peripheral blood of 24 women during pregnancy, and compared to NK activity of 40 healthy nonpregnant women in generative age. An increase in the first trimester was followed by a significant decline of NK activity in the second trimester, and a further fall in the third trimester of pregnancy. The initial rise of NK activity was predominantly due to primigravidas, whereas the fall in the second trimester was mainly due to multigravidas. There was a significant negative correlation between NK activity and the increasing levels of estrogen hormones (β-estradiol, estriol and estrone) in the sera of pregnant women. However, when analyzed for each trimester of pregnancy separately, a significant (p < 0.02) negative correlation was only found with β-estradiol, suggesting that high doses of this hormone could contribute to pregnancy-associated NK suppressio
ISSN:0378-7346
DOI:10.1159/000293766
出版商:S. Karger AG
年代:1988
数据来源: Karger
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5. |
Obstetrical Characteristics of a Loss of End-Diastolic Velocities in the Fetal Aorta and/or Umbilical Artery Using Doppler Ultrasound |
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Gynecologic and Obstetric Investigation,
Volume 25,
Issue 3,
1988,
Page 173-180
B. Arabin,
M. Siebert,
E. Jimenez,
E. Saling,
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摘要:
In 30 of 137 high-risk pregnancies we observed absent end-diastolic velocities indicating a high downstream impedance, which could be proved by histomorphological findings of the placenta. On the average the loss of end-diastolic velocities occurred 2–3 days before suspicious and nearly 8 days before pathological cardiotocographic findings. The perinatal mortality was high when absent velocities had been observed before the 32nd week, a cesarean section was obligatory in all but 1 case. All fetuses were growth-retarded. In 9 cases we were able to determine the ratio of blood flow volume in the common carotid arteries to that of the fetal aorta. The values were significantly increased as compared to values of undisturbed pregnancies, demonstrating a redistribution of fetal blood in favor of cerebral circulatio
ISSN:0378-7346
DOI:10.1159/000293767
出版商:S. Karger AG
年代:1988
数据来源: Karger
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6. |
Prediction of Sepsis Neonatorum following a Full-Term Pregnancy |
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Gynecologic and Obstetric Investigation,
Volume 25,
Issue 3,
1988,
Page 181-185
S. Ahldén,
B. Andersch,
L. Stigsson,
R. Olegård,
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摘要:
The aim of the present study was to identify obstetrical factors predicting sepsis neonatorum following a full-term pregnancy. In 1982 26 infants out of 2,977 full-term pregnancies had septicemia. For comparison 42 women of corresponding age were randomly selected. A stepwise regression analysis was performed in order to evaluate the association between seven different variables and sepsis neonatorum. We found that prolonged rupture of the membranes (p < 0.003) and primary amniotomy (p < 0.02) were the most important factors predicting sepsis neonatorum (r2 = 0.22). Factors such as cervical ripening, vaginal examinations, intrauterine monitoring devices, prolonged labor and prolonged pregnancy did not add to the predicted power of the analysis.
ISSN:0378-7346
DOI:10.1159/000293768
出版商:S. Karger AG
年代:1988
数据来源: Karger
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7. |
Quantification of the Fetal Heart Rate Variability by Spectral Analysis in Growth-Retarded Fetuses |
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Gynecologic and Obstetric Investigation,
Volume 25,
Issue 3,
1988,
Page 186-191
G. Breborowicz,
J. Moczko,
J. Gadzinowski,
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摘要:
The analysis of short-term variability of fetal heart rate in the frequency domain was performed. The fetal activity states (quiescence, trunk rotation, body movements, fetal breathing movements) were taken into account. The differences between the shapes of power spectra in physiological and growth-retarded fetuses were discussed.
ISSN:0378-7346
DOI:10.1159/000293769
出版商:S. Karger AG
年代:1988
数据来源: Karger
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8. |
Ovarian Morphology in Patients with Polycystic Ovaries and in an Age-Matched Reference Material |
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Gynecologic and Obstetric Investigation,
Volume 25,
Issue 3,
1988,
Page 192-201
Ottar Lunde,
Per Sigurd Hoel,
Leiv Sandvik,
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摘要:
The ovarian morphology in 149 patients with the clinical syndrome of polycystic ovaries (group I) is described. The ovaries from 10 age-matched women (group II) with no signs of ovarian disorder were investigated as a reference material. The number of cysts documented for group I was twice that of the reference group and the ovarian volume three times that of the normals. No significant difference in follicle number was seen between the two groups. The tunica albuginea was thicker in group I with more pronounced atretic changes. The duration of symptoms for group I correlated significantly with body mass index, thickening of tunica, degree of stromal hyperplasia and the calculated means of ovarian volume. A correlation was also seen between ovarian volume, degree of follicular atresia and stromal hyperplasia, as well as between the thickness of the tunica albuginea, number of follicles and degree of follicular atresia.
ISSN:0378-7346
DOI:10.1159/000293771
出版商:S. Karger AG
年代:1988
数据来源: Karger
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9. |
Ultrasonic Evaluation of Fallopian Tube Carcinoma |
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Gynecologic and Obstetric Investigation,
Volume 25,
Issue 3,
1988,
Page 202-208
Kazuhiko Yamamoto,
Setsushi Katoh,
Satoru Nakayama,
Satoshi Kijima,
Kentaro Takahashi,
Fuminori Murao,
Manabu Kitao,
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摘要:
Primary malignant neoplasms of the fallopian tube are the least common of all the gynecologic malignancies, and constitute only about 0.1–1% of all such malignancies. The actual 5-year survival is 64% in those with stage I, 60% in cases of stage II, and 18% and 25% for stages III and IV, respectively. Therefore, early detection of these neoplasm stages is most important to attain a cure. The preoperative diagnosis of this neoplasm has rarely been reported because these lesions are not common. We present herein the clinical and sonographic features in 4 Japanese women with fallopian tube carcinoma. While the sonographic features alone are not distinct enough to establish a definite preoperative diagnosis, the findings as seen in our patients suggest inclusion of tubal carcinoma in the differential diagnosi
ISSN:0378-7346
DOI:10.1159/000293773
出版商:S. Karger AG
年代:1988
数据来源: Karger
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10. |
Relaxin and Human Chorionic Gonadotropin Concentrations in Blood Serum during the First Trimester of Normal and Pathological Pregnancy |
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Gynecologic and Obstetric Investigation,
Volume 25,
Issue 3,
1988,
Page 209-212
H. Seeger,
M. Zwirner,
W. Voelter,
T.H. Lippert,
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摘要:
Relaxin and human chorionic gonadotropin (HCG) were determined in the blood serum of women during normal and pathological pregnancy in the 1 st trimester. In normal pregnancy, the hormones showed similar behavior in their secretion pattern up to the 7th week with continuously increasing concentrations. Thereafter different patterns in their secretion developed. In pathological pregnancy, both relaxin and HCG concentrations were significantly lower than in undisturbed pregnancy, following an almost parallel course without peaks.
ISSN:0378-7346
DOI:10.1159/000293775
出版商:S. Karger AG
年代:1988
数据来源: Karger
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