摘要:

The PAP immunocytochemical technique utilizing specific keratin antibody was applied to paraffin sections from 36 cervical biopsies. Normal squamous eptihelium and condylomas had similar patterns of keratin production with intense staining of intermediate and upper layers, while basal cells remained negative. Dysplasia, carcinoma in situ and infiltrating squamous carcinoma showed uneven distribution of keratin with the least amount seen in the areas with high mitotic rate and anaplasia. All large cell squamous carcinomas demonstrated presence of significant amouts of keratin. Squamous carcinomas of the small cell type were essentially keratin-free.

ISSN:0378-7346    

DOI:10.1159/000299040

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

A permanent line of epithelioid cells derived from a primary culture of rat endometrium by spontaneous transformation in vitro was studied as a model for the actions of estrogen on target cells. The cells contained typical cytosol and nuclear estrogen receptors. Estradiol added in vitro increased the accumulation of cells as much as 60% over controls. Cells injected into ovariectomized athymic mice grew into solid tumors whose incidence was increased by treatment of the animals with estradiol.

ISSN:0378-7346    

DOI:10.1159/000299041

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

21 women (mean age 60 years, range 48–72) were given depot medroxyprogesterone acetate (DMPA), 1,000 mg/week parenterally for 6 months, as part of the treatment for endometrial carcinoma in either clinical stage I or II. Before treatment and after 1, 3 and 6 months of treatment serum apolipoprotein AI was analyzed by electroimmunoassay. There was a significant decrease in apolipoprotein AI after the administration of DMPA, compared to the value before treatment. A low level of apolipoprotein AI is considered a risk factor for the development of atherosclerosis and cardiovascular disease. Such a risk might therefore be anticipated if the period of treatment was extended to several years.

ISSN:0378-7346    

DOI:10.1159/000299042

出版商:S. Karger AG    

年代:1984

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000315339

出版商:S. Karger AG    

年代:1903

数据来源: Karger

摘要:

As a model to investigate the pathogenesis of postmenopausal osteoporosis and the involvement of calcitonin in the bone alterations, we chose surgical menopause, studying the influence of castration on blood calcitonin. After surgery, the hormone and calcemia were raised significantly over preoperative values in castrated women, but not so in a control group of patients undergoing hysterectomy without oophorectomy. The elevated concentration of calcitonin was maintained during at least 4 months. It is speculated that this mechanism of control of calcitonin secretion by gonadal hormones might be activated in the pathogenesis of postmenopausal osteoporosis.

ISSN:0378-7346    

DOI:10.1159/000299043

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

Albumin, IgG and complement C3c were analyzed by immunonephelometry in cervical mucus collected daily at midcycle. There was a statistically significant difference in the amount of mucus recovered on the day of the luteinizing hormone (LH) surge and on the following day. Several nadirs in protein concentration could be visualized in 8 out of 14 subjects, whereas in 6 subjects, no such changes in concentration were found. In terms of soluble protein concentrations and amounts there were no differences between cycle days. For changes in soluble protein concentrations and amounts, no systematic time relation to the LH peak could be found.

ISSN:0378-7346    

DOI:10.1159/000299044

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

Midcycle cervical secretions were collected every hour from 08.00 to 12.00 h in 12 normal women. There was a significant decrease in gram wet weight of mucus in the first four samples followed by an increase in the fifth specimen (trend analysis). Spinnbarkeit decreased significantly during repeated sample collection. Albumin concentration in cervical secretion increased significantly during repeated sample collection, but there was no statistically significant difference in the total amount of albumin recovered during repeated sample collection. The possibility of a hormonal regulation of the water content in the cervical mucus is discussed.

ISSN:0378-7346    

DOI:10.1159/000299045

出版商:S. Karger AG    

年代:1984

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000315343

出版商:S. Karger AG    

年代:1903

数据来源: Karger

摘要:

40 women who underwent amniocentesis were administered the Symptom Questionnaire to evaluate changes in psychological distress. Anxiety, depression, somatic symptoms and hostility significantly decreased after the results of the procedure were communicated to the patient, replicating the findings in a previous study. Psychological distress, however, returned to the initial levels in the third trimester of pregnancy. Women whose only indication for amniocentesis was an age of 35 years or older displayed significantly higher hostility and somatic symptoms and less contentment before the procedure than the other women. Subsequently these differences lost their significance and the two groups showed similar patterns of psychological distress throughout the pregnancy.

ISSN:0378-7346    

DOI:10.1159/000299046

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

Maternal and cord serum calcium, copper, iron and zinc concentrations were analyzed in 20 women with a postdate pregnancy. The control group consisted of 20 parturients with delivery at term and their newborns. Serum free estriol (E3) was also determined. Maternal serum copper, zinc and E3 were statistically significantly lower, while cord serum copper and fetomaternal ratio of zinc were significantly higher in the study group than in the control group. Further, a positive correlation between E3 and maternal serum copper level (r = 0.63) was found.

ISSN:0378-7346    

DOI:10.1159/000299047

出版商:S. Karger AG    

年代:1984

数据来源: Karger