摘要:

Cytoplasmic receptors for 17β-estradiol (ER) and progesterone (PR) were measured in vulvar carcinomas. Tissues from 12 patients were examined. 5 of the vulvar carcinomas had detectable amounts of ER of whom 1 also had positive PR. Tissue samples from normal vulvar skin in 9 of the same patients were also examined for ER and PR activity. 3 had positive ER only and 1 had both ER and PR activity. The concentration of ER in cancer tissue showed a binding capacity of 2–23 pmol/g cytosol protein. In receptor-positive normal vulvar skin the binding capacity of ER ranged between 4 and 10 pmol/g cytosol protein. The binding capacity or PR, positive in 1 vulvar carcinoma and in 1 normal skin sample, was 12 and 10 pmol/g cytosol protein, respectively.

ISSN:0378-7346    

DOI:10.1159/000299164

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

The influence of different oral contraceptives on the prevalence and severity of dysmenorrhea was investigated in a representative sample of 19-year-old women from an urban Swedish population. The prevalence and severity of dysmenorrhea were significantly (p < 0.01) reduced amongst users of progestogen-dominated oral contraceptives compared to a control group of women who used neither oral contraceptives nor an intrauterine device. However, there was no significant difference in the prevalence and severity of dysmenorrhea between users of oral contraceptives with low progestogen activity and the same control group. Thus, the relative progestogen activity of the oral contraceptive used appears to be of importance for the effective treatment of dysmenorrhea. Possible reasons for the superior therapeutic efficacy of progestogen-dominated oral contraceptives are discussed. Further studies are, however, necessary to evaluate the importance of the progestogen activity of oral contraceptives in the treatment of dysmenorrhea.

ISSN:0378-7346    

DOI:10.1159/000299165

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

The relationship between progressive diabetes and endometrial structure was examined in genetically diabetic Chinese hamsters. Uterine samples were collected from animals exhibiting prediabetic to overt diabetic conditions and from matched control animals. In controls (with blood glucose levels ≤145 mg/dl) the endometrium was typified by an intact luminal epithelium, a thin underlying basement membrane and a well-organized stroma layer. In contrast, mildly diabetic (150–250 mg/dl) animals exhibited a compressed luminal epithelium which was embedded in a thickened basement membrane infiltrated with phagocytic blood elements. The stromal layer contained several irregular cells which were characterized by cytoplasmic vacuolization and collagen fiber separation by an amyloid-like, intercellular ground substance. In overt diabetic animals (≥300–500 mg/dl), the luminal epithelial cells were located over a greatly thickened basement membrane which was infiltrated by phagocytic blood elements and degenerating stromal cell membranes. The lumens of the glands were closed and the stromal cells were separated by an increased intercellular space occupied by an amyloid-like ground substance. Many stromal cells exhibited cytoplasmic vacuolization. These studies demonstrate that uterine involution associated with diabetes occurs in a sequential manner and is temporally related to progressive elevations in blood glucose levels.

ISSN:0378-7346    

DOI:10.1159/000299166

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

We measured maternal venous (MV), umbilical arterial (UA), and umbilical venous (UV) cortisol levels of 180 pregnancies at term. The cortisol level of MV was higher than that of UA and UV in all deliveries. The cortisol levels of three samples had no difference between the induced labor group and the spontaneous onset of labor group regardless of delivery mode. In spontaneous vaginal delivery the cortisol levels of three individual samples were significantly higher in primipara than in multipara. The positive correlations were observed in any modes of deliveries between the cortisol levels of MV and UA, and MV and UV, and UA and UV. These data suggest that the fetus may produce cortisol by itself and maternal cortisol may inflow to the fetus.

ISSN:0378-7346    

DOI:10.1159/000299167

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

In this study the human decidua, chorion and amnion were incubated for short term. Only the decidua, secreted much prolactin clearly among them as a function of time. When the amounts of prolactin in the maternal blood, cord blood obtained from umbilical vein, or those released into decidual incubation medium were compared with the amniotic fluid prolactin levels, only the decidual prolactin correlated significantly with the amniotic fluid prolactin. The urine obtained from newborns showed a low concentration of prolactin. These results suggest that the origin of prolactin present in the amniotic fluid is not from the mother or fetus, but from the decidua which has the ability of producing prolactin, and that prolactin secreted from this tissue may be transported into the amniotic fluid through the fetal membrane and accumulated there.

ISSN:0378-7346    

DOI:10.1159/000299168

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

The effects of bolus injections of 1.0–80.0 μg/kg body weight fenoterol on urinary excretion, osmolarity and electrolytes were studied in unanesthetized, water-loaded rabbits. In animals infused initially with isotonic solution over 2 h with 60 ml/h and thereafter over 10 h with 45 ml/h, urine excretion was 538 ml/l2 h, sodium excretion was 65.4 mmol/l2 h, and potassium excretion was 4.8 mmol/l2 h. In animals injected with 5.0–80.0 μg/kg body weight fenoterol, a strong antidiuresis occurred, lasting for 2 (10.0 μg/kg) to 4 h (80.0 μg/kg). Due to the strong antidiuresis, urinary osmolarity was significantly elevated for 2 (10.0 μg/kg) to 3 h (80.0 μg/kg). The changes of sodium excretion after fenoterol injection were very similar to those of urine excretion. Maximum reduction of sodium excretion was found after injection of 10.0–80.0 μg/kg body weight fenoterol, the effect lasting for 1 h (10.0 μg/kg) to 4 h (80.0 μg/kg). Potassium excretion was significantly reduced after injection of 5.0–80.0 μg/kg body weight fenoterol. In contrast to all the other parameters measured, potassium excretion remained significantly reduced until the end of the infusion period in animals treated with 10.0–80.0 μg/kg body weight fenoterol and was not dose dependent. Our data presented in this work extend earlier findings in the rabbit in that bolus injection of fenoterol also results in a drastic decrease of urine and electrolyte excretion. The results are discussed with special reference for the management of acute fetal distress with betamimetics and to the development of pulmonary edema that has been shown to occur under therapy with betamimetics on both female rabbits and humans.

ISSN:0378-7346    

DOI:10.1159/000299169

出版商:S. Karger AG    

年代:1984

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000299170

出版商:S. Karger AG    

年代:1984

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000299171

出版商:S. Karger AG    

年代:1984

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000299172

出版商:S. Karger AG    

年代:1984

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000283957

出版商:S. Karger AG    

年代:1903

数据来源: Karger