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1. |
Rational Design and Application of Idiotope Vaccines |
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International Reviews of Immunology,
Volume 1,
Issue 1,
1986,
Page 1-26
KieberThomas,
WardRonald E.,
RaychaudhuriSyamal,
ReinRobert,
KohlerHeinz,
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摘要:
Current emphasis on risk factors associated with established vaccines and pressing needs for vaccines against certain viral transmitted diseases have stimulated the search for new conceptual and practical approaches to vaccine production. Among these developments, the idiotope vaccine method has produced promising results.In this review the basic and conceptual principles for idiotype vaccine design are discussed. A novel approach for identifying idiotopic structures in the three dimensional structure of internal idiotope antigens is developed. The method is based on the relationship of the immune response with the evolutionary variation and diversity of the immunoglobulin family. Idiotopic structures are found in specialized topographic regions on the surface of the immunoglobulin molecule. The knowledge of these idiotope domains will facilitate the synthesis of idiotope expressing peptides and the computer modeling of the three dimensional structure of internal idiotope antigens.Finally, the existing evidence for successful application of the idiotope vaccine method is summarized and new disease groups are identified which could benefit from the development of idiotope vaccines.
ISSN:0883-0185
DOI:10.3109/08830188609056598
出版商:Taylor&Francis
年代:1986
数据来源: Taylor
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2. |
Monoclonal Anti-Idiotypic Antibodies as Surrogates for Hepatitis B Surface Antigen |
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International Reviews of Immunology,
Volume 1,
Issue 1,
1986,
Page 27-39
ThanavalaYasmin M.,
RoittI. M.,
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ISSN:0883-0185
DOI:10.3109/08830188609056599
出版商:Taylor&Francis
年代:1986
数据来源: Taylor
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3. |
Induction of Anti-Viral Immunity by an Anti-Idiotypic Antibody Directed to a Sendai Virus Specific T Helper Cell Clone |
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International Reviews of Immunology,
Volume 1,
Issue 1,
1986,
Page 41-65
ErtlHildegund C. J.,
SkinnerMargot A.,
FinbergRobert W.,
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ISSN:0883-0185
DOI:10.3109/08830188609056600
出版商:Taylor&Francis
年代:1986
数据来源: Taylor
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4. |
Anti-Idiotypic Antibodies as Idiotope Vaccines that Induce Immunity Against Infectious Agents |
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International Reviews of Immunology,
Volume 1,
Issue 1,
1986,
Page 67-78
KennedyRonald C.,
DreesmanGordon R.,
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ISSN:0883-0185
DOI:10.3109/08830188609056601
出版商:Taylor&Francis
年代:1986
数据来源: Taylor
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5. |
Anti-Idiotypic Antibodies of Reovirus as Biochemical and Immunological Mimics |
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International Reviews of Immunology,
Volume 1,
Issue 1,
1986,
Page 79-90
GaultonGlen N.,
GreeneMark I.,
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ISSN:0883-0185
DOI:10.3109/08830188609056602
出版商:Taylor&Francis
年代:1986
数据来源: Taylor
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6. |
Editorial |
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International Reviews of Immunology,
Volume 1,
Issue 1,
1986,
Page -
KöhlerHeinz,
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ISSN:0883-0185
DOI:10.3109/08830188609056597
出版商:Taylor&Francis
年代:1986
数据来源: Taylor
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