ISSN:0148-639X    

DOI:10.1002/mus.880080602

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

摘要:

AbstractMononeuropathy multiplex is a syndrome of diverse causes, the most common of which is nerve ischemia due to microangiopathy associated with diabetes or the collagen‐vascular diseases. The acquired inflammatory demyelinating neuropathies invariably are multifocal, although the clinical manifestations of these and other multifocal neuropathies may appear symmetrical. The identification of multifocal neuropathies is important because of the frequent therapeutic implications. A case of mononeuropathy multiplex associated with polyarteritis nodosa is describe

ISSN:0148-639X    

DOI:10.1002/mus.880080603

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

摘要:

AbstractThe question of how the supinator syndrome and the posterior interosseous syndrome are (or are not) related has not been well discussed in the literature. The anatomy of the radial nerve and its innervations is quite variable, as are the etiology, presentation, and clinical findings in the lesions of the posterior interosseous nerve. The present study was based on a retrospective review of the electrodiagnostic records of 12 patients with involvement of the deep radial nerve (posterior interosseous nerve) diagnosed at the EMG lab of New York University Medical Center from 1975 to 1983. Two‐thirds of these patients had electrophys iologic abnormalities of the supinator muscle, and in the remainder, the supinator was not involved. All superficial radial nerves had normal evoked mode action potential amplitudes and latencies. We propose that the supinator syndrome is a special case of the posterior interosseous syndrom

ISSN:0148-639X    

DOI:10.1002/mus.880080604

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

摘要:

AbstractBoth tension and stiffness as a function of muscle length were measured under relaxing conditions on isolated small bundles of chemically skinned myofibers from normal and dystrophic chicken pectoral muscles. It was shown that the dystrophic muscle was stiffer than normal muscle and developed more tension for the same amount of stretch. A fraction of stiffness was not removed by extraction with either 0.6M Klor with 5Mguanidine HCl mixed with 1% mercaptoethanol. The stiffness of dystrophic muscle was also unaffected by treatment with bacterial collagenase under conditions that destroyed the stiffness of tendon. Nyquist plots of normal and dystrophic muscles during calcium‐activated isometric contraction were very similar and were characteristic of fast‐twitch muscle, as evidenced by three clear exponential processes. The normal appearance of the Nyquist plot of dystrophic muscle demonstrates that cross‐bridge function is not altered, and the characteristic slowing of contraction and relaxation is not a consequence of a fast‐to‐slow transformation of muscle types. The increased stiffness of dystrophic muscle may be a very fundamental change in the biomechanics of dystrophy. We postulate that the stiffness is mediated by an altered form of collagen, which is collagenase‐resistant by virtue of excessive c

ISSN:0148-639X    

DOI:10.1002/mus.880080605

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

摘要:

AbstractSomatosensory evoked potential (SEP) investigations in 18 patients with lower limb lesions are summarized. Seven patients had problems involving the lateral femoral cutaneous nerve, four the femoral nerve, and seven the sciatic nerve. All lesions were unilateral. SEP techniques were accurate in meralgia paresthetica, and all five patients with demonstrable SEP abnormalities were successfully treated surgically. Delayed recovery of sensory function was shown in two patients with femoral nerve lesions and two patients with sciatic nerve lesions. In patients with sensory symptoms, only an SEP abnormality confined to the nerve distribution provides evidence of a lesion in the sensory pathways and helps to exclude psychologic causes. In a case of peripheral nerve Schwannoma, the presence of a small delay in a case of peripheral SEP supported the preoperative assessment that the tumor was not intrinsic in nature, and this was confirmed at surgery and on subsequent full recovery. The SEP technique allows quantitative assessment of sensory nerve conduction through the peripheral neuron and centripetal pathways.

ISSN:0148-639X    

DOI:10.1002/mus.880080606

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

摘要:

AbstractWhen antisera to purified myelin antigens were injected into rat sciatic nerves, some produced significant demyelination, whereas others merely induced an inflammatory infiltrate. Extensive demyelination was produced by antisera to galactocerebroside and the peripheral nerve glycoprotein P0. Demyelination resulting from injections of antisera to ganglioside GM1, P2, myelin basic protein, sulfatide, and glucocerebroside did not exceed that produced by normal rabbit serum. Addition of guinea pig complement had no effect. It is of interest that the greatest demyelination followed injection of antisera to two molecules, galactocerebroside and P0, the main antigenic determinants of which present at the Schwann cell surface.

ISSN:0148-639X    

DOI:10.1002/mus.880080607

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

摘要:

AbstractSubjects with myopathies associated with certain enzyme defects often show abnormal concentrations of lactate (LA) and ammonia (NH3) in blood after ischemic exercise. Myoadenylate deaminase (MAD) deficient patients produce only small amounts of NH3, whereas LA rises to normal levels. On the other hand, patients with certain enzyme deficiencies in the glyco(geno)lytic pathway show the opposite. However, the concentrations in blood are dependent on the exercise performed. Standardization of tests for screening purposes, therefore, is necessary. For ischemic contractions, experiments were performed to find the optimal combination for force and frequency, using the highest LA and NH3concentrations in blood as criteria. Eleven healthy subjects performed ischemic isometric contractions with a handgrip dynamometer at frequencies of 30 and 50/min−1and force levels of 50%, 65%, and 80% of maximal voluntary contraction (MVC). A combination of 30/min−1and 80% MVC was found to give the best resu

ISSN:0148-639X    

DOI:10.1002/mus.880080608

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

摘要:

AbstractWe reviewed 180 electroneuromyographic (EMG) studies from patients with acute inflammatory demyelinating polyradiculoneuropathy. EMG criteria suggestive of demyelination were met during the first 5 weeks in 87% of patients; an additional 10% had indeterminate electrodiagnostic evaluations, and 3% demonstrated axonal degeneration only. Motor nerve conduction abnormalities initially predominated, with the nadir of abnormality occurring at week 3. Sensory nerve conduction abnormalities peaked during week 4 and were atypical for polyneuropathy, with 52% of patients having normal sural but abnormal median sensory studies, perhaps reflecting distal nerve involvement. Delayed sensory abnormalities may reflect, in part, secondary involvement related to increased intraneural edema accentuated by compression at sites of anatomic vulnerability. Fibrillation potentials and increased polyphasia appeared between weeks 2 and 5 in proximal and distal muscles simultaneously, which is consistent with either random axonal degeneration at any point along the axon or distal involvement. Resolution of conduction abnormalities began between weeks 6 and 10, with increased mean motor‐evoked amplitude best reflecting functional clinical recover

ISSN:0148-639X    

DOI:10.1002/mus.880080609

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

ISSN:0148-639X    

DOI:10.1002/mus.880080610

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

ISSN:0148-639X    

DOI:10.1002/mus.880080611

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY