ISSN:0148-639X    

DOI:10.1002/mus.880010402

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY

摘要:

AbstractThis article discusses various entrapment neuropathies as well as their clinical features and treatment. In most patients with compression neuropathies, diagnosis and therapy can be effected early if a careful neurologic examination as well as x‐ray and electrodiagnostic (EMG and nerve conduction) studies are performed when the patient initially presents with symptom

ISSN:0148-639X    

DOI:10.1002/mus.880010403

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY

摘要:

AbstractMyosins isolated from individual human muscles (primarily normal muscles) were investigated with respect to their structural and catalytic properties. The results indicate unexpected elements of uniformity shared by the several myosins, such as a three‐banded, electrophoretic pattern of light chains in sodium dodecylsulfate (SDS) gels and a low degree of alkaline lability. The pH activity profile and the effect of KCl on myosin ATPase activities were also found to be the same for the myosins from predominantly fast (e.g., vastus lateralis and rectus abdominis) and slow (e.g., soleus and pectoralis minor) muscles. Coelectrophoretic experiments lend further credence to the interrelationship between human myosin light chains and the light chains of rabbit fast‐muscle myosin. However, several kinds of circumstantial evidence, such as that derived from the study of myosin in nemaline myopathy, suggest that one should exercise caution in interpreting these results. On the other hand, human muscle myosins, like those of other mammalian species, can be divided into two main categories according to the peptide composition of tryptic heavy meromyosin (HMM) and the banding pattern of light meromyosin (LMM) paracrystals. These results, which are indicative of differences in the primary structure of the heavy chains, allow us to identify these heavy chains as the main site of heterogeneity among myosins in human musc

ISSN:0148-639X    

DOI:10.1002/mus.880010404

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY

摘要:

AbstractOf 115 patients with acute intermittent porphyria seen during a 20‐year period, 11 had experienced an acute episode of quadriparesis. Nerve conduction studies performed on 8 of these 11 patients showed lowamplitude compound action potentials and normal velocity measurements. Needle electromyography demonstrated prominent fibrillation potentials, especially in proximal muscles. The changes in these findings with time confirm that this disorder is an acute axonal neuropath

ISSN:0148-639X    

DOI:10.1002/mus.880010405

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY

摘要:

AbstractA family is described in which five males have late‐onset facial weakness, dysarthria, dysphagia, and slowly progressive proximal weakness. Electrodiagnostic studies and muscle biopsy were compatible with spinal muscular atrophy. This family appears quite similar to several previously reported families with late‐onset X‐linked recessive spinal and bulbar muscular atrophy. Because of the relative homogeneity of this particular phenotype of spinal muscular atrophy, a single metabolic derangement was sought. Three obligate carriers were studied, and no abnormality was detected. A further family with this condition is briefly disc

ISSN:0148-639X    

DOI:10.1002/mus.880010406

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY

摘要:

AbstractEvidence is presented for the existence of many different systems of proteolytic enzymes in human skeletal muscle. These include the lysosomal system of cathepsins as well as proteinases and peptide hydrolases that are optimally active at neutral and alkaline pH ranges. The majority of proteolytic enzymes examined are found to show increased activity in dystrophic human muscle. Moreover, a high initial rise is observed in cathepsin B1, a thiol‐dependent endopeptidase of lysosomes, and in dipeptidyl peptidase IV, a membrane‐associated peptidase. In addition, a calcium‐activated neutral proteinase is found to be significantly elevated in muscle from patients with Duchenne dystrophy. The possible roles of these proteinases in intracellular protein catabolism and muscle wasting are disc

ISSN:0148-639X    

DOI:10.1002/mus.880010407

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY

摘要:

AbstractThe ability of classical hormones or extract from adult chicken tissues to replace or influence the activity of chicken skeletal muscle cell trophic factor was investigated. Pituitary gland extract did not replace the trophic factor in a range equivalent to the serum concentrations of somatotropin, although high concentrations of such extract showed a significant ability to mimic trophic‐factor activity. Insulin, triiodothyronine, testosterone, dihydrotestosterone (Stanolone), and estradiol did not show any ability to mimic trophic‐factor activity. Both pituitary extract and insulin showed a potentiating effect on the trophic factor when added to the medium; however, the concentrations necessary for this effect were too high to be considered physiologic. Triiodothyronine, testosterone, Stanolone, and estradiol did not potentiate the trophic factor; indeed, at higher concentrations, these hormones actuallysuppressedthe activity of the trophic factor. Every tissue extract examined showed, to a greater or lesser extent, the ability to potentiate the trophic fac

ISSN:0148-639X    

DOI:10.1002/mus.880010408

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY

摘要:

AbstractRepeated injections of testosterone into hens and roosters gave rise to a reversible increase in the activity of muscle cell trophic factor in serum.

ISSN:0148-639X    

DOI:10.1002/mus.880010409

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY

摘要:

AbstractA clinically normal adult male rabbit was found to possess fascicles of muscle fibers within the leptomeninges over the spinal cord at L6, L7, and S1. The finding is believed to be purely incidental and unrelated to any experimental procedure. Morphologically, the fascicles had the characteristics of striated muscle; and, while most were of normal dimensions, several were made up of small fibers 4–10 μm in diameter. Motor endplates, capillaries, and endomysial and perimysial connective tissue were also present. Axons myelinated by Schwann cells were associated with the normal bundles but were absent from the bundles of small fibers. In such bundles, large, unmyelinated axons predominated, some of which lacked ensheathment while others were invested by perineurial‐type cells. The observation of incidental intraleptomeningeal skeletal muscle probably reflects a rare developmental anomaly. Its occurrence in humans is also discu

ISSN:0148-639X    

DOI:10.1002/mus.880010410

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY

摘要:

AbstractA case of lumbar plexus neuropathy occurring in the setting of heparin therapy is reported. Documentation of the site of a retroperitoneal hematoma by CT scan was made prior to the full clinical evolution of a lumbar plexus neuropathy resulting from a psoas‐muscle hematoma. Two patterns of retroperitoneal bleeding and their respective clinical manifestations are discussed. Early diagnosis of these syndromes may allow for intervention before neurologic compromise is establishe

ISSN:0148-639X    

DOI:10.1002/mus.880010411

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY