摘要:

AbstractA case report is presented of a 33‐year‐old woman who awoke with distal paresthesias, mild incoordination, and progressive weakness. Examination 3 days later demonstrated weakness of the extremities, which was greater in distal muscles than in proximal ones, mild facial weakness, distal vibratory loss, and areflexia. Electrodiagnostic studies provided evidence of an acquired demyelinating polyradiculoneuropathy of recent onset. Motor conduction studies revealed abnormal temporal dispersion and partial conduction block. Preserved sural responses with abnormal median sensory conduction studies supported the diagnosis of Guillain‐Barré syndrome, as did subsequent cerebrospinal fluid examinations documenting increasing total protein, identification of preceding cytomegalovirus injection with increasing serum convalescent titer, and progressive clinical improvement after a brief plateau. The role of electrodiagnosis in establishing the diagnosis and prognosis in Guillain‐Barré syndrome is

ISSN:0148-639X    

DOI:10.1002/mus.880120902

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY

摘要:

AbstractTo evaluate cold and warmth cutaneous sensation separately, thermal discrimination thresholds (TDTs) for the foot were estimated for cold and warm stimuli in 71 normal subjects aged between 21 and 92 years. A “thermoaesthesiometer” operating on the Peltier principle was used. A rise of TDTs with age was found. Furthermore, female subjects appeared to have lower thresholds than males. Independent of age or gender, TDTs for cold stimuli were on average lower than for warm stimuli. In accordance with other studies, a large intraindividual variability was found, which emphasizes the necessity for repeated measureme

ISSN:0148-639X    

DOI:10.1002/mus.880120903

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY

摘要:

AbstractThree patients with idiopathic hemifacial spasm were studied clinically and electrophysiologically before and after injections of botulinum toxin into the involved periocular and facial muscles. The spasms were improved for approximately 3 months, and the effect was repeatable on reinjection. The spasms diminished only as long as the muscles were clinically weak, and spasms were observed electromyographically even though therapy eliminated the clinical spasms. Uninjected muscles continued to have spasms. Transmission of excitation from the zygomatic branch to the marginal mandibular branch of the facial nerve and vice versa in all patients was unaltered after therapy, but the amplitude of the response was decreased. The efficacy of botulinum toxin in hemifacial spasm appears to be related to the production of muscle weakness; there is no demonstrable effect on phenomena believed to be ectopic excitation or ephaptic transmission in the facial nerve.

ISSN:0148-639X    

DOI:10.1002/mus.880120904

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY

摘要:

AbstractAxonal regeneration through silicone tubes was studied using distal nerve stumps, denervated, preatrophied muscle tissue, as well as fat tissue as a target. During the first stage of regeneration, i.e., within 2–3 weeks after surgery, a thin, filamentous structure consisting of fibrin and connective tissue‐was seen bridging the gap in all systems. Thereafter, this cord obviously served as a guideline for the outgrowth of increasing numbers of axons into distal nerve stumps as well as into muscle tissue, but not into fat tissue. These findings confirm that preatrophied muscle tissue has a similar “neurotrophic” effect on regenerating nerve fibers as distal nerve stumps. The ineffectivity of fat tissue in promoting nerve fiber regeneration could be attributed either to the absence of “neurotrophic factors” or even to an inhibi

ISSN:0148-639X    

DOI:10.1002/mus.880120905

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY

摘要:

AbstractBecause digit 4 (D4) has dual innervation, median and ulnar sensory latencies can be determined over identical distances. To determine if D4 testing is more sensitive than other commonly used techniques to diagnose carpal tunnel syndrome (CTS), we examined 42 hands with clinical evidence of carpal tunnel syndrome and 43 control hands. D4 latency was significantly longer than controls more often than digit 2 (D2) in patients with CTS. Comparing median to ulnar latencies from D4 was the most sensitive method to make the diagnosis of CTS. in mild CTS, a characteristic double peak potential was seen in recordings from the median nerve after stimulating D4. This potential provided immediate visual confirmation of the diagnosis of CTS. Comparing D4 latency along median and ulnar nerves is useful for detecting mild CTS and should be used whenever there are clinical signs and symptoms of CTS but electrodiagnostic studies are normal or borderline.

ISSN:0148-639X    

DOI:10.1002/mus.880120906

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY

摘要:

AbstractTo determine whether abnormality in redox metabolism occurs specifically in certain individual dystrophic muscles, thiobarbituric acid reactivity, free radical scavengers, and oxidative marker enzymes were measured in the liver, kidney, erythrocytes, heart, and four different individual skeletal muscles from‐C57BL/6J dy/dy mice. Superoxide dismutases were assayed by specific radioimmunoassays, which enabled the study of a small individual murine muscle. Glutathione peroxidase and catalase were increased markedly in each individual dystrophic skeletal muscle studied and less markedly in the heart. Manganosuperoxide dismutase and thiobarbituric acid reactivity were decreased to a similar extent in each dystrophic skeletal muscle. Cuprozinc superoxide dismutase was decreased in the soleus muscle. Only a minimal biochemical change occurred in nonmuscles. Fumarase activity correlated closely with the level of manganosuperoxide dismutase. These results suggest that muscle protein breakdown occurs independently of lipid peroxidation despite the presence of tissue‐specific abnormality of redox metabolism in dystrophic mus

ISSN:0148-639X    

DOI:10.1002/mus.880120907

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY

ISSN:0148-639X    

DOI:10.1002/mus.880120908

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY

ISSN:0148-639X    

DOI:10.1002/mus.880120909

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY

ISSN:0148-639X    

DOI:10.1002/mus.880120910

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY

ISSN:0148-639X    

DOI:10.1002/mus.880120911

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY