摘要:

ABSTRACTThe crude incidence rate for cancer of the breast far exceeds that for any other type of cancer found in either sex. In women it is nearly twice the rate for the next most common malignant disease found in both men and women. The percentage of patients with localized disease has gradually increased but now is approaching a plateau. There is a definite increase in the incidence of breast cancer in premenopausal women which counterbalances the better results with reference to age‐specific death rates. The absolute survival rate indicates that mortality rates continue to be “above normal” for a considerable period beyond the five‐year point. It is important, therefore, to study the challenge which confronts us, to keep in mind the natural history of the disease, to review the known high‐risk factors and tumor‐host relationships, and to evaluate continually all available diagnostic and therapeutic measures. These measures include those not used in routine practice, and especially those involving n

ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1978.tb01218.x

年代:1978

数据来源: WILEY

摘要:

ABSTRACTThe cardiovascular and lung lesions in 23 centenarians (7 males and 16 females) were examined pathologically. The heart showed varied degrees of hypertrophy, and myocardial fibrosis was present in 15 of the 23 patients. Coronary arteriosclerosis was noted coincidentally. In addition to these findings, amyloid deposition was seen in the hearts of 8 patients. Generalized atherosclerosis of the arterial tree was severe to moderate in all cases. Bronchopneumonia was present in 15 of the 23 patients, and fresh or old thromboembolism in 8. There was a tendency toward emphysema and chronic bronchitis in the structure of the lung. The frequent occurrence of myocardial fibrosis and bronchopneumonia was characteristic in the series. It was significant that cardiac amyloid deposition was noted in these cases.

ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1978.tb01219.x

年代:1978

数据来源: WILEY

摘要:

ABSTRACTSeveral tests of thyroid function were performed in 35 hyperthyroid patients over the age of 65 (elderly). The results were compared to those of similar tests in 48 hyperthyroid patients under the age of 65 (young). Total serum thyroxine (T4) was within the normal range in 14 per cent of the elderly and 11 percent of the young hyperthyroid patients. The free thyroxine index (FTI) was within the normal range in 11 percent of both groups. The triiodothyronine uptake (T3U) proved to be a poor test in both groups. Although elevation of the triiodothyronine (T3) level allowed a diagnosis of “T3‐toxicosis” in 2 elderly and 3 young hyperthyroid patients, the T3level was normal in 34 percent of the elderly and 13 percent of the young subjects. Correction of the T3range for age reduced the number of normal T3values to 12.5 percent in the elderly hyperthyroid patients. The 24‐hour uptake of radioactive iodine was normal in 12 percent of the young hyperthyroid patients, 27 percent of the elderly patients with Graves' disease, and 70 percent of the elderly patients with toxic nodular goiter, despite recent readjustment of the normal range for the test. It is concluded that the diagnosis of hyperthyroidism in the elderly may be difficult and that no single test can be relied upon to exclude the di

ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1978.tb01220.x

年代:1978

数据来源: WILEY

摘要:

ABSTRACTColestipol hydrochloride (Colestid) lowered the serum cholesterol level significantly more than did placebo in hypercholesterolemic patients (21 colestipol, 19 placebo) treated for up to 5 years. In the 21 colestipol‐treated patients, the average decrease in serum cholesterol levels was 19 percent during the first year and 23 percent during the second through fifth years. Seven patients (age range, 44 to 59 years) took colestipol for the full 5 years. The data showed a consistent lowering of the serum cholesterol level. The only side effect was constipatio

ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1978.tb01221.x

年代:1978

数据来源: WILEY

摘要:

ABSTRACTA 45‐year old woman with Huntington's disease (HD) was followed for three years while under an anticoagulant‐psychotherapy regimen. The chorea disappeared and the patient improved rather than deteriorating as predicted. All psychotropic drugs were discontinued. This case of reversal of the disease may help to confirm the hypothesis that HD is probably due to circulatory insufficiency in the substantia ni

ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1978.tb01222.x

年代:1978

数据来源: WILEY

摘要:

ABSTRACTA study was made of the effects of community nutrition services on 234 noninstitutional elderly aged 65 or older. Many of the problems were related to overweight and longstanding inappropriate food habits. The results indicated that counselling can stimulate an increased awareness of nutrition and improvement in the knowledge of nutrition and food selection. These elderly persons seemed to have a definite desire to achieve good health and were receptive to the nutritionist's recommendations. However, economic and physical limitations often influenced their ability to adhere to the recommendations. In counselling the elderly, the nutritionist should be able to make a quick assessment of the elderly person's physical capabilities.

ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1978.tb01223.x

年代:1978

数据来源: WILEY

摘要:

ABSTRACTAn elderly depressed couple with multiple physical problems decided that death was preferable to their present lifestyle, and made a suicide pact. At the last minute the wife felt unable to go through with it and the couple entered a psychiatric hospital. During their 3‐week stay they were treated appropriately with amitriptyline and psychotherapy. Since discharge they have been followed closely for two years. Some psycho‐ and socio‐dynamic and therapeutic aspects are disc

ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1978.tb01224.x

年代:1978

数据来源: WILEY

ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1978.tb01225.x

年代:1978

数据来源: WILEY