摘要:

ABSTRACTAvailable evidence suggests that age is an important determinant of the levels of neurotransmitters and their associated enzymes and metabolites in some regions of the brain. Alterations at the synaptic level, or selective cell death in the brain, or both, may be implicated in progressive loss of function, behavioral changes and the onset of age‐related diseases. Stimulation of hypothalamic neuroendocrine transducer cells by agents that alter neurotransmitter metabolism might provide some measure of control of the process of agin

ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1977.tb00657.x

年代:1977

数据来源: WILEY

摘要:

ABSTRACTThe relationship of age to insulin resistance was determined in 100 nonobese men whose ages ranged from 22 to 69 years. Seventy of the 100 subjects had normal glucose tolerance, and 30 had chemical diabetes. Insulin resistance was estimated by measuring the steady‐state plasma glucose response to a continuous infusion of insulin, glucose, epinephrine, and propranolol. This approach permitted inhibition of endogenous insulin release, achievement of a comparable steady‐state plasma level of exogenous insulin, and use of the height of the steady‐state plasma glucose response as a direct estimate of insulin resistance. With this experimental method, no correlation was found between age and insulin resistance over the age span of the experimental population. Furthermore, there was no correlation between age and the height of the plasma glucose response to an oral glucose challenge in this population of nonobese, healthy ambulator

ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1977.tb00658.x

年代:1977

数据来源: WILEY

摘要:

ABSTRACTLymphocyte reactivity in cultures toward the nonspecific T and B cell mitogens, phytohemagglutinin (PHA) and pokeweed (PWM), was studied in 46 subjects in three groups: a) young healthy persons, b) elderly healthy persons, and c) hospitalized elderly patients with atherosclerotic cardiovascular disease. No statistically significant differences in the lymphocyte reactivity of young and old healthy persons toward PHA could be observed with different incubation times, mitogen concentrations, or serum sources. A significantly decreased lymphocyte response was found in elderly hospitalized patients compared to young and elderly healthy subjects. In contrast, no differences in the lymphocyte reactivity toward PWM could be found among the three groups, including a comparison between elderly healthy and elderly hospitalized persons. The results suggest that the B lymphocyte‐dependent response to a B lymphocyte stimulator is more stable than is the T cell response in aged subject

ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1977.tb00659.x

年代:1977

数据来源: WILEY

摘要:

ABSTRACTTwelve patients who attended a daytime session in a hemodialysis unit were studied. Most were older than patients whose adaptation has been the subject of previous reports. Problems of life satisfaction for these elderly patients often are different from those for younger persons. Most of the group showed maladaptive reactions which interfered with their activities when away from the unit. The Draw‐A‐Person test was a useful tool in pinpointing these reactions, which can lead to feelings of helplessness and depression. Factors which encourage good adaptation to long‐term hemodialysis are disc

ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1977.tb00660.x

年代:1977

数据来源: WILEY

摘要:

ABSTRACTA survey was made of the patterns of hospital admission for patients aged 65 or older in an urban practice under the management of a primary care team composed of a family physician, nurse, and medical social worker. Results showed that the elderly used a higher percentage of in‐hospital facilities than did the younger age groups. However, admission rates were significantly lower than the local national rates, and involved relatively fewer cases of long‐term illness. No patients over 65 were admitted for psychiatric care during the one‐year period of observation. This was attributed to the provision of planned domiciliary programs for supervision of patients with long‐term illness within a coordinated framework of primary medic

ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1977.tb00661.x

年代:1977

数据来源: WILEY

摘要:

ABSTRACTPatients with a primary diagnosis of “postoperative hip fracture” often have a poor prognosis because of their inability to participate in rehabilitation programs. They tend to remain in a state of physical inactivity and sensory deprivation. The signs and symptoms of head injury associated with the hip fracture may be overlooked and attributed to sensory deprivation. Thirty‐nine patients with fractured hip and 18 with multiple fractures were studied by means of electroencephalography, echoencephalography, and computer axial tomography. In 7, the findings indicated a cerebral lesion. At operation, a subdural hematoma was found in 5 patients and a tumor in 2; all but one made a dramatic recovery. Thus, after hip fracture, it is important that the patient be tested appropriately so that signs and symptoms of sensory deprivation may not be confused with those of an occult head injury. When indicated, surgical intervention may be a life‐saving

ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1977.tb00662.x

年代:1977

数据来源: WILEY

摘要:

ABSTRACTA combination of three psychiatric screening tests was used to uncover the extent of affective‐psychotic symptoms, the indications of “chronic brain syndrome,” and the perceptual limitations among two selected populations of elderly persons. It was found that 25 percent of 48 residents in a home for the aged, and 9 percent of 45 members in a social club, had four or more affective‐psychotic complaints. In the former group, 75 percent had symptoms of moderate to severe “chronic brain syndrome,” versus 7 percent in the latter group. Among the residents of the home, 10 percent had serious disturbances as measured by all three tests. The significant number of affective‐psychotic symptoms found in this population with extensive manifestations classifiable as “chronic brain syndrome” indicates that this diagnosis should not be allowed to preclude regular psychiatric evaluation of these elderly patients. When a specific diagnosis is established, available treatment modalities should be p

ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1977.tb00663.x

年代:1977

数据来源: WILEY

摘要:

ABSTRACTReports on aneurysm of the arteries of the wrist and hand are relatively rare. Presented here is a case of true aneurysm of the radial artery in a 41‐year‐old man. The patient had an enlarging painful swelling on the volar aspect of the left wrist, of six months’ duration. Under local anesthesia, a transverse incision over the wrist crease revealed an arterial aneurysm. The aneurysm was excised, followed by end‐to‐end anastomosis. The patient recovered uneventfully and was discharged nine days after the operation. A follow‐up arteriogram, five years later, showed a patent radial artery with good blood flow. This is an excellent example of a successful reconstructive surgical procedure involving a s

ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1977.tb00664.x

年代:1977

数据来源: WILEY

摘要:

ABSTRACTThe second heart sound was studied by phonocardiography and carotid tracings in 103 elderly subjects without overt evidence of heart disease. Their ages ranged from 60 to 99 years. A normal type of splitting was found in 55.3 percent, and a single sound in 41.7 percent. The difference between these percentages and those found in 60 normal younger persons was not significant. Thus, a single second sound should not be considered a typical finding in old age. However, a reverse type of splitting, noted in only 3 patients, should be regarded as evidence of severe latent heart disease.

ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1977.tb00665.x

年代:1977

数据来源: WILEY

ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1977.tb00666.x

年代:1977

数据来源: WILEY