摘要:

ABSTRACTA survey was made of the electroencephalographic (EEG) changes during the human lifespan. It was found that the EEG changes during childhood and adolescent maturation continue even between the ages of 30 and 60 years. There is a decrease in the abundance of alpha activity, with a reduction in the fast part and a relative increase in the slow part of the alpha band. In the span of life between 60 and 90, there is an increase of slow waves with a progressive slowing during the aging process and a shift in the dominant frequency from 9 cps to 7 cps. Computerization of results in the beta band (above 13 cps) enables differentiation of the waves of the lower part (13–25 cps) from those of the upper part (above 25–30 cps). The lower part of the beta band decreases parallel to the alpha activity but the upper part of the beta band increases in amount during the aging process. The meaning of the divergent behavior of these sub‐groups of beta activity in the aged is discussed. The EEG seems to be an important factor in the study of aged pe

ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1977.tb00282.x

年代:1977

数据来源: WILEY

摘要:

ABSTRACTMaudsley Tests of the Sensorium (used by clinicians to assess verbal memory and orientation) and Kendall's Memory for Design (used by psychologists to assess visual memory) were employed to differentiate between elderly patients with organic brain damage (neurologic disease, chiefly stroke) and those with functional psychiatric disorders which had been present in youth. There were 25 patients in each group. Both tests differentiated organic from functional disorders. There was no statistically significant difference in the effectiveness of the two tests.

ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1977.tb00283.x

年代:1977

数据来源: WILEY

摘要:

ABSTRACTWhen the serum insulin values during a 50‐gm oral glucose tolerance test were expressed as the function of glucose concentrations, a good linear relationship was found in normal subjects and in patients with diabetes, hyperthyroidism, hypothyroidism or chronic hepatitis. The insulin index calculated from the line representing this relationship was less than 100 in all 19 diabetic patients and most of the 13 hyperthyroid patients with oxyhyperglycemia, whereas it was more than 100 in the 14 normal subjects, the 4 hypothyroid patients, and the 8 patients with oxyhyperglycemia due to chronic hepatitis. The insulin index decreased with increasing maximal blood glucose concentration during the glucose tolerance test in diabetic patients. Furthermore, improvement in the insulin index was correlated with the effectiveness of sulfonylurea drugs in the diabetic grou

ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1977.tb00284.x

年代:1977

数据来源: WILEY

摘要:

ABSTRACTEvidence is provided to show that the account of “The Climacteric Disease” given in 1813 by Sir Henry Halford, Physician to King George III, was his interpretation that the King's illness was due to aging as a disease. This laid foundations upon which are placed the unfavorable attitudes toward Geriatric Medicine today, and which may affect the provision of medical care for the elderly and aged tomor

ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1977.tb00285.x

年代:1977

数据来源: WILEY

摘要:

ABSTRACTNinety aged patients at the Philadelphia Geriatric Center were asked to give answers to a 35‐item mental status questionnaire which included a new visual counting test. By this means it was found that 20 of the 90 subjects were not mentally impaired, but 34 had mild dementia, 17 moderate dementia, and 19 severe dementia. These results proved to be well correlated with the clinical findings. The test records showed that as dementia develops, the first thing to be forgotten is the awareness of time, place and recognition (in that order). Then the ability to count disappears. As mental oblivion intervenes, the last thing the patient forgets is his/her own name. It was also noted that patients with mild senile dementia fared better when kept with a similar group than with patients who have moderate or severe dementi

ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1977.tb00286.x

年代:1977

数据来源: WILEY

摘要:

ABSTRACTAssociations between socioeconomic score (SES) and age‐related statural loss were investigated in a cross‐sectional sample of 718 adults from rural Colombia. Estimates of statural aging were calculated by estimating the maximum statural attainment of each subject from statural relationships with subischial length. Statural loss was correlated with SES, r = –0.06 (not significant) for men, and r = –0.14 (p<0.01) for women. Subjects with a high SES tended to lose stature at a slower rate than those with a low SES. For women, the difference in rates of statural loss between the two SES groups was significant (

ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1977.tb00287.x

年代:1977

数据来源: WILEY

摘要:

ABSTRACTThis report concerns a 41‐year‐old man with total lipodystrophy associated with a specific renal disorder. He had massive proteinuria, mild azotemia and a normal level of serum complement in addition to the generalized loss of subcutaneous fatty tissue. Results of a 50‐gm glucose tolerance test indicated a high fasting insulin level with an exaggerated response to glucose. Hypoglycemic responses to exogenous insulin were reduced. Renal biopsy revealed changes consistent with glomerular lipidosis. This case is unique in that the renal lesion was not the Kimmelstiel‐Wilson pathologic change attributable to abnormal glucose met

ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1977.tb00288.x

年代:1977

数据来源: WILEY

摘要:

ABSTRACTThe paradoxic biologic behavior of tissue calcium metabolism is emphasized. Although calcium salts are essential for the development of bones, they also contribute to aging of the large human arteries. The heavy elements providing α‐ray activity tend to be metabolized like calcium. The concept of an osteoporosis‐atherosclerosis relationship led to a series of investigations in which ash content and α‐ray activity were examined in abdominal aortas, coronary arteries, pulmonary arteries and, for comparison, in bones and ventral costal cartilages. Both ash content and α‐ray activity rise with age in the aorta and in the coronary arteries, but there is no such increase in the pulmonary arteries. A statistically significant correlation between ash content and α‐ray activity has been found only in aortas and coronary arteries. This correlation is even closer in the coronary arteries of subjects who die of coronary artery disease and in the aortas of the elderly. Wet tissue α‐ray activity in an aorta with severe atherosclerosis may be 220 times higher than in an aorta without significant atherosclerosis. Alpha‐activity in bones and in ventral costal cartilages tends to decline in advancing years, though in the cartilages the calcium deposits increase with age. Our studies reveal a close relationship between atherogenesis and the unique metabolic behavior of α‐ray radiation in the

ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1977.tb00289.x

年代:1977

数据来源: WILEY

摘要:

ABSTRACTIn 50 patients with coronary heart disease (CHD) and 38 controls, comparative data on age, sex, serum cholesterol level, hypertension, obesity, diabetes, smoking habits, and ear‐lobe creases were analyzed statistically. After adjustment for age differences, the factors which chiefly distinguished the two groups were the incidences of smoking, obesity, diabetes, and ear‐lobe creases. Of these, the ear‐lobe crease seemed to be correlated best with CHD, and may prove to be a useful diagnostic

ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1977.tb00290.x

年代:1977

数据来源: WILEY

摘要:

ABSTRACTThis study was conducted to compare an automated test of paced stimulus material (Sperling's Perceptual Trace, SPT) with several other standard memory scales. Sixty patients with mild senile organic brain syndrome were divided into two groups of 30; one group was treated for 90 days with 300 mg daily of naftidrofuryl (Praxilene), and the other group received placebo. The patients were tested before treatment and at 30, 60 and 90 days after the beginning of treatment. The data indicated that the SPT indirectly assesses short‐term memory, is resistant to practice effects, and is drug‐sensitive. It is suggested that the SPT might become the test of choice in the indirect assessment of short‐term memory in the el

ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1977.tb00291.x

年代:1977

数据来源: WILEY