ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1984.tb04165.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1984.tb04166.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

Alpha‐1‐acid glycoprotein concentration and imipramine binding to plasma proteins were determined in a cohort of 69 subjects, aged 20–97 years. No subject had evidence of acute or chronic inflammatory disease or malignancy, or was receiving tricyclic antidepressant therapy. Alpha‐1‐acid glycoprotein concentration increased significantly with increasing age (r= 0.28;P<0.02). Imipramine percentage not bound to plasma proteins was negatively related to alpha‐1‐acid glycoprotein concentration (r= −0.30;P<0.01); however, there was no relationship between subject age and percentage imipramine unbound. Though alpha‐1‐acid glycoprotein concentration increases with advancing age, because only a small proportion of the variability is explained by age, with other undefined factors being more important, drugs predominantly bound to alpha‐1‐acid glycoprotein such as imipramine may not have a clinically or statistically significant change in protein binding with increasing age in the absence of

ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1984.tb04167.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

Blood levels of 12 vitamins were compared in 55 patients with Alzheimer's disease and 58 control subjects (10 intellectually alert, 12 depressed, 28 multi‐infarct dementias, 8 with other specific dementias). No significant differences in vitamin blood levels were found between the Alzheimer's disease group and the control groups either individually or in total. Conventional parenteral vitamin treatment of seven patients with vitamin deficits did not benefit their cognitive state. Conventional vitamin malnutrition did not seem to contribute to the disability in these subject

ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1984.tb04168.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

Previous studies found changes in regional cerebral blood flow (rCBF) patterns related to both age and various cognitive tasks. However, no study has yet demonstrated a relationship between rCBF and performance on the Luria‐Nebraska Neuropsychological Battery (LNNB) in an elderly group. Seventy‐nine elderly volunteers (56–88 years old), both healthy and demented, underwent the133xenon inhalation rCBF procedure and were given the LNNB. The decrements in the gray‐matter blood flow paralleled decrements in performance on the LNNB. Using partial correlations, a significant proportion of shared variance was observed between gray‐matter blood flow and the LNNB scales. However, there was much less of a relationship between white‐matter blood flow and performance on the LNNB. This study suggests that even within a restricted age sample rCBF is related in a global way to neuropsychological

ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1984.tb04169.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

Folic acid and vitamin B12nutritional status was examined in a group of 270 healthy elderly individuals using both dietary and biochemical measures. Of these 40 per cent had dietary intakes of folic acid that were less than half the recommended dietary allowance of 400 μg/day, and 13 per cent had intakes of less than half the recommended dietary allowance for vitamin B12(3 μg/day). However, only 8 per cent had low plasma folates (<3.0 ng/ml) and only 3 per cent had RBC folates less than 140 ng/ml. Plasma true cobalamin levels less than 220 pg/ml were found in 3 per cent. None of these individuals showed any clinical signs of folate and/or vitamin B12deficiency, and mean corpuscular volumes were not significantly greater than those for the entire population (90.8 ± 4.1 fl). The correlations of intakes of folic acid and vitamin B12with plasma or erythrocyte levels were moderate (about 0.5). It was also clear that those taking supplements had significantly greater blood levels than those not taking supplements, although the benefit of higher plasma or erythrocyte levels of these nutrients is not clear. The data indicate that folate and vitamin B12status in free‐living healthy elderly is not a major medical pro

ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1984.tb04170.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

To assess the involvement of hospitals in geriatric, community and long‐term care services, a survey was undertaken of the 104 acute care hospitals in Massachusetts. Results show that hospitals (N = 81) are adding geriatric expertise but as yet have taken on community services and long‐term care only to a small extent. Hospitals perceive major deficiencies in physician service to nursing homes (89 per cent) and in availability of inpatient geriatric units (94 per cent). Responding hospitals have targeted for development by 1985 geriatric inpatient units (17 per cent), respite care (16 per cent), and hospice care (16 per cent). The financial implications of the survey results are discussed with respect to prospective reimbursement and public health implicati

ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1984.tb04171.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1984.tb04172.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1984.tb04173.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

Attitudes held by geriatric patients, their families, and hospital staff are frequent obstacles to successful rehabilitation following acute illness. These attitudes interfere with patients' motivation for increasing physical independence and result in patients' becoming stranded at a more dependent level of function. Three distinct attitudes frequently encountered in geriatric rehabilitation are identified: the prejudice of ageism, the right of dependency, and the apathy of fatigue. Recognition of these attitudinal syndromes permits effective treatment interventions to enable poorly motivated geriatric rehabilitation patients to progress towards functional independence.

ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1984.tb04174.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY