摘要:

AbstractSalicylamide amino acid conjugates were prepared utilizing 5‐formyl‐, 5‐dicyanoethenyl‐, and 5‐nitroethenylsalicylic acid. 5‐Substituted salicylanilides were treated with glycine and formaldehyde in aMannichtype reaction affording the corresponding 3‐(N‐glycino)salicylanilides. The reactions of anilines with pyrans containing the salicylyl moiety yielded the corresponding salicylanilides. The obtained compounds were tested for mollusc

ISSN:0365-6233    

DOI:10.1002/ardp.19943270402

出版商:WILEY‐VCH Verlag    

年代:1994

数据来源: WILEY

摘要:

AbstractHighly substituted chalcones1do not react with two molecules of hydroxylamine affording dioximes2or hydroxyamino‐oximes3as expected according tovon Auwers' procedure: only one molecule of hydroxylamine is consumed leading totrans‐configurated 2‐benzoyl‐3‐phenyl‐1H

ISSN:0365-6233    

DOI:10.1002/ardp.19943270403

出版商:WILEY‐VCH Verlag    

年代:1994

数据来源: WILEY

摘要:

AbstractNew cyclic derivatives derived from 4‐methyl‐7‐coumarinyloxyacetic acid hydrazide have been synthesized. Some representative examples were screened for antimicrobial act

ISSN:0365-6233    

DOI:10.1002/ardp.19943270404

出版商:WILEY‐VCH Verlag    

年代:1994

数据来源: WILEY

摘要:

AbstractThe synthesis of some impurities of the cephalosporin antibiotics cefalexin and cefradine is described. These impurities which may be present in commercial samples are formed during the semi‐synthetic preparation of these antibiotics or upon their degradation. The preparation of these compounds enables the validation of selective quantitative analytical methods, such as column liquid chromatography and thin layer chromatograph

ISSN:0365-6233    

DOI:10.1002/ardp.19943270405

出版商:WILEY‐VCH Verlag    

年代:1994

数据来源: WILEY

摘要:

AbstractDie Titelverbindungen4b‐g,10a,bund13lassen sich durch “Cyclokondensation” der 1,3‐Biselektrophilela‐e,5b,f,g, 7b,d, 8a,bund12mit 2,4,6‐Triaminopyrimidin (2) in verbesserten Ausb.

ISSN:0365-6233    

DOI:10.1002/ardp.19943270406

出版商:WILEY‐VCH Verlag    

年代:1994

数据来源: WILEY

摘要:

AbstractDie Titelverbindungen lassen sich auf zwei verschiedenen Wegen herstellen: Durch Ringschlußreaktionen des 2‐Benzazepin‐enaminonitrils1mit den C2‐Bausteinen2, 7und8sind die Tricyclen6, 9und10zugänglich. ‐Beim zweiten Weg werden die 2‐Amino‐3‐benzoylpyridine16a,bzu den 2‐Amino‐3‐benzylpyridinen18a,breduziert. Benzoylierung von18a,bführt zu den Dibenzoylverbindungen20und21, die sich in die Monobenzoylverbindungen22und23überführen lassen. Ringschluß nach Art derBischler‐Napieralski‐Reaktion führt mit22a,bund23a,bzu den 5H‐Pyrido[2,3‐c]‐2‐benzazepinen24a,b, und25a,b. ‐ Mittels1H‐,13C‐ und15NNMR‐Daten wird bewiesen, daß Benzoylacetimidsäureethylester

ISSN:0365-6233    

DOI:10.1002/ardp.19943270407

出版商:WILEY‐VCH Verlag    

年代:1994

数据来源: WILEY

摘要:

AbstractAs a result of the reaction of salicylic amide with PCl3and POCl32‐chloro‐2,3‐dihydro‐1,3,2‐benzoxazaphosphorin‐4‐one (1) and its 2‐oxide2are obtained. Compounds1and2form amides with amines in 2‐position. Antineoplastic action of the derivatives containing the bis(2‐chloroethyl)amide group in 2

ISSN:0365-6233    

DOI:10.1002/ardp.19943270408

出版商:WILEY‐VCH Verlag    

年代:1994

数据来源: WILEY

摘要:

AbstractFour structurally different cyclic imides or related derivatives (o‐(N‐phthalimido)acetophenone (1), 2,3‐dihydrophthalazine‐1,4‐dione (2),N‐(4‐methylphenyl)diphenamide (3), and 4,6‐dihydro‐5H‐dibenz[c,e]azepine (4) were examined for acute toxicity in mice at multiple doses, for long term toxicity at a single dose in rats, and for deleterious effects on fertility and pup development in rodents. No deleterious effects were observed when mice were administered agents at 20, 50, and 100 mg/kg/day for seven days. All other measured characteristics and values were normal for the four compounds. The principle effect of the compounds was to reduce the percent pregnancies in treated mice compared to the controls. Compound2afforded the greatest reduction of pregnancy (54%) at 100 mg/kg/day. Compounds3and4caused a minor reduction in pregnancy (12‐20%). The compounds did not appear to cause measureable teratogenic effects; pups of treated rodents thrived and survived as well as controls. There were no effects on murine male fertility when compounds were administered at 20, 50, and 100 mg

ISSN:0365-6233    

DOI:10.1002/ardp.19943270409

出版商:WILEY‐VCH Verlag    

年代:1994

数据来源: WILEY

摘要:

AbstractDie Beziehungen zwischen chemischer Struktur und antifungieller Wirkung von 72 quaternären Pyridiniumchloriden wurden mit der Grob‐Mengen‐Methode analysiert. Im Informationssystem wurden die Verbindungen mit acht Bedingungsattributen beschrieben und in drei Klassen der Aktivität eingeteilt. Die Berechnungen ergeben eine kleinste Untermenge von vier Bedingungsattributen, die signifikant für die hohe Qualität der Klassifikation und für die Genauigkeit der Klassen waren. Der resultierende Entscheidungsalgorithmus zeigt wesentliche Beziehungen zwischen der antifungiellen Wirkung von Pyridiniumverbindungen und den auf signifikante Bedingungsattribute reduzierte Strukturmerkmalen. Der Entscheidungsalgorithmus gibt Hinweise, die bei Synthesen neuer antifungiell wirksamer Verbindungen behilflich sei

ISSN:0365-6233    

DOI:10.1002/ardp.19943270410

出版商:WILEY‐VCH Verlag    

年代:1994

数据来源: WILEY

摘要:

AbstractThe synthesis of the title compound3is described. Its performance in Passive Cutaneous Anaphylaxis (PCA) testing was evaluated.

ISSN:0365-6233    

DOI:10.1002/ardp.19943270411

出版商:WILEY‐VCH Verlag    

年代:1994

数据来源: WILEY