摘要:

ABSTRACTA prototype LH‐RH antagonist dampened the proestrous gonadotropin surge and blocked ovulation but had no effect on pregnant animals. In contrast, LH‐RH and two highly potent LH‐RH agonists terminated pregnancy when administrated prior to or following implantation. This contragestational effect, as well as other antireproductive properties of the agonists, coupled with the reversibility of their effects, strongly suggest that such peptides may provide a new basis for contraception.

ISSN:0020-6695    

DOI:10.1002/j.1879-3479.1979.tb00466.x

出版商:Wiley    

年代:2016

数据来源: WILEY

摘要:

ABSTRACTOne hundred fifty postligation and 54 random cases matched for age and parity were studied. Vaginal cytologic samples and endometrial histologic samples were used for cytohormonal assessment of ovarian function. There was no indication of ovarian insufficiency following tubal ligation. The menstrual cycles were ovulatory. Menstrual disturbances were seen in 40.6% of the cases following tubal ligation. Cytohormonal comparison of these cases with that of dysfunctional uterine bleeding cases (who did not undergo tubal ligation) showed either similar or high maturation value. This may be due either to psychological stimulation or to low‐grade infection following tubal ligation. There was complete cytomorphologic correlation.

ISSN:0020-6695    

DOI:10.1002/j.1879-3479.1979.tb00467.x

出版商:Wiley    

年代:2016

数据来源: WILEY

摘要:

ABSTRACTTo determine the effect of oral administration of thyrotropin‐releasing hormone (TRH) on the thyroid function and on the composition of breast milk in the early puerperium, six lactating women were treated with a single dose of 40 mg of synthetic TRH and six women were treated with placebo. Serial serum samples taken before and between one and 25 hours after TRH administration were assayed with specific radioimmunoassays for thyrotropin (TSH), triiodothyronine (T3) and total thyroxine (T4). Milk samples were collected three times a day and their major fatty acids were determined by gas‐liquid chromatography and were compared with those obtained from normal lactating women. A statistically significant TSH elevation was observed between one and six hours after TRH administration, with a peak value of 23.7 ± 10.6 mU/liter at three hours. The T3concentration rose between three and nine hours after TRH administration, with a peak of 6.3 ± 1.2 nmole/liter at six hours. The T4elevation was statistically significant between six and 12 hours after TRH administration. The fatty acid content of milk samples from women treated with TRH did not differ from the normal series. A single daily dose of oral TRH thus caused a temporary thyroid stimulation. It is doubtful whether this could lead to hyperthyroidism since the levels of thyroid hormones became normal within ten hours after TRH administration.

ISSN:0020-6695    

DOI:10.1002/j.1879-3479.1979.tb00468.x

出版商:Wiley    

年代:2016

数据来源: WILEY

摘要:

ABSTRACTThe efficacy of caproate of hydroxyprogesterone and acetate of chlormadinone in preventing premature labore was compared in a controlled trial. The survey was based on 211 pregnant women with a high risk of premature delivery discovered during clinical examination. There are no significant differences between the two groups in either length of gestation, delay between the beginning of treatment and delivery or other parameters related to prematurity. The absence of evidence suggesting any significant difference between the two treatments can have three possible causes (which are discussed): the methodology, the inefficacy of the two products or the equivalent efficacy of the two products.

ISSN:0020-6695    

DOI:10.1002/j.1879-3479.1979.tb00469.x

出版商:Wiley    

年代:2016

数据来源: WILEY

摘要:

ABSTRACTEpidural analgesia was used for 86 deliveries by cesarean section. The placement of a catheter in the epidural space allowed adjustment of the extent of the block so that supplementary analgesia was required in only six patients. Continuous fetal heart rate monitoring was of practical clinical value, especially in treating maternal hypotension. Symptomatic hypotension was avoided or corrected by the intravenous infusion of Hartmann's solution and by the use of a lateral tilt of the operating table. Eleven patients had a blood pressure of less than 100 mm Hg, and in three of these, there was an adverse effect on the fetal heart trace.

ISSN:0020-6695    

DOI:10.1002/j.1879-3479.1979.tb00470.x

出版商:Wiley    

年代:2016

数据来源: WILEY

摘要:

ABSTRACTA comparative study of carcinoembryonic antigen (CEA) and β2‐microglobulin (β2‐MG) in serum was made by radioimmunoassay in 77 women with genital cancer. With a positive level defined as 5 ng of CEA/ml and 3.0 μg of β2‐MG/ml, CEA was positive in 31% of the women with cancer of the corpus, 36% of those with cancer of the cervix and 36% of those with cancer of the ovary; the corresponding figures for β2‐MG were 6%, 27% and 56%, respectively. The additional use of β2‐MG provided an increase in positive results, especially in cases of cancer of the ovary. A direct relationship between the extent of tumor and serum marker level was more evident for β2‐MG than CEA. There was no correlation between serial levels of CEA and β2‐MG in most patients. CEA levels appeared to predict subsequent tumor behavior more accurately in patients with good prognoses (ie, complete or partial tumor response), whereas β2‐MG levels gave the same prediction in those with bad prognoses (ie, nonresponsive or progressive tumor).

ISSN:0020-6695    

DOI:10.1002/j.1879-3479.1979.tb00471.x

出版商:Wiley    

年代:2016

数据来源: WILEY

摘要:

ABSTRACTThe effects of two sequential therapies using mestranol as an estrogen and chlormadinone acetate and norethisterone acetate, respectively, as a gestagen on the aminotransferase (GOT and GPT), alkaline phosphatase and α‐amylase activities, the cholesterol, total bilirubin and total protein contents and the indocyanine green (Ujoviridin, VEB Chemiekombinat Bitterfeld) half‐life were studied in two groups, each comprising 12 women of fertile age. The serum protein was separated by paper electrophoresis and both the thymol turbidity and zinc sulphate tests were performed during the first treatment cycle. An estrogen‐induced rise in alanine aminotransferase (GPT) activity from 6.31 U/liter to 12.14 U/liter was observed during application of the mestranol/chlormadinone acetate therapy. The value dropped to 5.34 U/liter when chlormadinone acetate was administered as a gestagen in addition to the estrogen. No significant changes were noted in the other biochemical parameters.Sequential therapy involving application of mestranol and norethisterone acetate produced only statistically secured rises in the α1‐globulin content and the GPT activity. All other changes in the different parameters remained within the normal range and were statistically insignificant.

ISSN:0020-6695    

DOI:10.1002/j.1879-3479.1979.tb00472.x

出版商:Wiley    

年代:2016

数据来源: WILEY

摘要:

ABSTRACTBilateral tubal pregnancy was confirmed by histologic examination in a 32‐year‐old multipara with an intrauterine contraceptive device (IUD) in situ. The patient had developed intraperitoneal bleeding and hypovolemic shock. Bilateral salpingectomy was performed and was followed by a rapid recovery.

ISSN:0020-6695    

DOI:10.1002/j.1879-3479.1979.tb00473.x

出版商:Wiley    

年代:2016

数据来源: WILEY

摘要:

ABSTRACTAssessment was made of the fibrinolytic activity in menstrual and peripheral blood of 30 normally menstruating and 30 menorrhagic patients and of 30 women wearing Lippes Loops and 15 wearing CU‐T(200)s. Assessment was performed by measuring the area of lysis on heated and unheated fibrin plates. Also, histochemical identification of fibrin fibrils in the menstrual endometrium was performed by Mallory's phosphotungstic acid hematoxylin method. Results in the normally menstruating group were compared to those of the menorrhagic women, and together these were compared with results in the groups of women wearing intrauterine devices. The fibrinolytic activity in menstrual blood was significantly increased in menorrhagic patients compared to that in normally menstruating patients, but no significant difference was detected in the plasma of either group. The histochemical study of the normally menstruating endometrium revealed dense intravascular and extravascular deposits of fibrin. Less dense intravascular fibrin deposits, but no extravascular ones, were present in the menorrhagic patients. The increase in the fibrinolytic activity of menstrual blood and the decrease in the density of fibrin deposits in the menstrual endometrium of the menorrhagic women were thus associated and were probably involved in the excessive menstrual loss. The fibrinolytic activity of menstrual blood in women wearing Lippes Loops was higher than that in women with Cu‐T(200)s and was associated with decreased density of fibrin fibrils in the menstruating endometrium. This may explain the increased blood loss associated with the use of the Lippes Loop.

ISSN:0020-6695    

DOI:10.1002/j.1879-3479.1979.tb00474.x

出版商:Wiley    

年代:2016

数据来源: WILEY

摘要:

ABSTRACTThe influence of religion, education and socioeconomic status on opinion regarding medical termination of pregnancy were examined. A random sample of 514 married, urban women was selected. The study revealed that religion, education and economic status influenced the formation of opinion regarding pregnancy termination. The women gave many reasons for considering it beneficial. The most common reasons were that pregnancy termination offered increased opportunities for better education and nutrition. The limitation of family size and elimination of unwanted pregnancies were also noted as needs of the community.

ISSN:0020-6695    

DOI:10.1002/j.1879-3479.1979.tb00475.x

出版商:Wiley    

年代:2016

数据来源: WILEY