摘要:

ABSTRACTBasal cell carcinoma was found in eight of 61 cases of vulvar malignancy occurring over a 20‐year period. This incidence of basal cell carcinoma was 13.1%, higher than the expected 2%–5% reported previously in the literature. Symptoms of a mass, usually discharge, pruritus or bleeding, were commonly ignored for long periods of time by the elderly patient. The specific location and size were difficult to ascertain from hospital records. Therapy is always surgical with wide local excision recommended. Local recurrence will be noted in 10%–20%, as vulvar basal cell carcinoma is a multicentric lesion and, therefore, long‐term follow‐up, as with any malignancy, is mandatory. Adequate identification and reporting may well show that this lesion is more common than has been previously thought.

ISSN:0020-6695    

DOI:10.1002/j.1879-3479.1979.tb00150.x

出版商:Wiley    

年代:2016

数据来源: WILEY

摘要:

ABSTRACTA woman with disseminated choriocarcinoma and with clinical and biochemical evidence of thyrotoxicosis is described. Only a few cases have been previously reported, and works are referred to showing that high levels of human chorionic gonadotropin (HCG) probably are responsible for the thyroid‐stimulating activity in patients with trophoblastic disease and clinical signs of thyrotoxicosis.

ISSN:0020-6695    

DOI:10.1002/j.1879-3479.1979.tb00151.x

出版商:Wiley    

年代:2016

数据来源: WILEY

摘要:

ABSTRACTAmong 3205 patients who needed major gynecologic operations, only 250 (7.8%) had significant ovarian cysts or tumors (170 benign, 38 “low malignant potential,” 42 gross cancers). Contrary to prior reports, this study shows that most patients with ovarian neoplasia had had some symptoms (duration ranged from two weeks to ten years), or a palpable adnexal mass or both. Associated symptoms have been itemized in categories. Procrastination by patients, after occurrence of the first symptoms, resulted in the growth of later‐stage cancers and lower survival rates. It may be inferred from age‐incidence graphs that some benign cystadenomas may be present in ovaries for long intervals of time and then may become malignant. The importance of (a) careful recording of histories, (b) periodic pelvic examinations, (c) the use of preoperative methods of differential diagnosis and (d) the differentiation between gross tumor characteristics during operations are discussed. Earlier diagnosis and treatment of ovarian neoplasia are possible and will yield better long‐term results.

ISSN:0020-6695    

DOI:10.1002/j.1879-3479.1979.tb00152.x

出版商:Wiley    

年代:2016

数据来源: WILEY

摘要:

ABSTRACTTo establish the cell type responsible for the production of estrogens in an ovarian tumor, seven thecomas, three granulosa cell tumors and one fibroma were studied with electron microscopy. The secretion of estrogens by the tumor was determined by measuring the plasma levels of estrogens in the ovarian and cubital veins of some patients and examining the histology of the endometria. Polygonal cells with abundant smooth endoplasmic reticulum (SER) at the ultrastructural level were found in the tumors of patients with clinical signs of hyperestrogenism. It is likely that these cells are the site of steroidogenesis, which is known to be reflected by SER in the cells of the human corpus luteum.

ISSN:0020-6695    

DOI:10.1002/j.1879-3479.1979.tb00153.x

出版商:Wiley    

年代:2016

数据来源: WILEY

摘要:

ABSTRACTEight cases of adenocystic carcinoma of the uterine cervix, a rare histologic variant, are presented, with a brief review of 41 cases previously reported in the literature. They represent only 0.27% of 3254 cervical carcinomas that we encountered between 1962 and 1977. In all eight cases, there was early parametrial involvement, and the majority behaved aggressively. All eight patients were multiparas, and six of them were postmenopausal. Interestingly, including this series, 15 of 49 reported cases of this entity have been from India.

ISSN:0020-6695    

DOI:10.1002/j.1879-3479.1979.tb00154.x

出版商:Wiley    

年代:2016

数据来源: WILEY

摘要:

ABSTRACTA case of an umbilical mass as a primary presenting symptom of otherwise asymptomatic endometrial adenocarcinoma is reported. The pertinent literature is reviewed with regard to the relation of the umbilical mass to metastatic carcinoma.

ISSN:0020-6695    

DOI:10.1002/j.1879-3479.1979.tb00155.x

出版商:Wiley    

年代:2016

数据来源: WILEY

摘要:

ABSTRACTA sporadic case of a woman presenting with the combination of pure 46,XX gonadal dysgenesis and congenital nerve deafness is reported. A similar association had been reported as a rare familial occurrence. The apparent heterogeneity of phenotypic characteristics among the previously reported individuals and the possible genetic implications are discussed.

ISSN:0020-6695    

DOI:10.1002/j.1879-3479.1979.tb00156.x

出版商:Wiley    

年代:2016

数据来源: WILEY

摘要:

ABSTRACTFour cases with suspected sex chromosomal abnormalities and clinical features and endocrine data typical of Turner syndrome are presented. Chromosome preparations made from skin fibroblasts and peripheral blood and multiple banding techniques employed to map the genes of their X chromosomes showed variable results. A review of the literature also revealed conflicting findings regarding the mapping of genes on the X chromosome. Despite different cytogenetic findings, the clinical features of the four cases presented were quite similar.

ISSN:0020-6695    

DOI:10.1002/j.1879-3479.1979.tb00157.x

出版商:Wiley    

年代:2016

数据来源: WILEY

摘要:

ABSTRACTA comparative study of the efficacy of oral prostaglandin E2and buccal tablets of demoxytocin for induction of labor in overdue pregnancies was made in groups of randomly selected patients. Labor was successfully induced in 95.7% of the women in the prostaglandin group and 92.1% of the women in the demoxytocin group. Although the operative delivery rate was low in both groups, it was significantly higher for the demoxytocin group. A low rate of perinatal distress was recorded and there were no serious side effects in either group. The time from start of induction until delivery, as well as the time from amniotomy until delivery, were compared for primiparae and multiparae separately. No significant differences were found. The blood loss during the third stage of labor was lower in the prostaglandin group. We find oral induction of labor in overdue pregnancies effective, safe and convenient.

ISSN:0020-6695    

DOI:10.1002/j.1879-3479.1979.tb00158.x

出版商:Wiley    

年代:2016

数据来源: WILEY

摘要:

ABSTRACTA triad consisting of (a) prostaglandin F2αinfusion, (b) dilation of the uterine cervix by low frequency vibrations and (c) early low amniotomy was used to induce labor in ten women after intrauterine fetal death had occurred. Vaginal delivery was successful in all cases, with a mean induction‐to‐delivery interval of 5.4 ± 0.8 hours. Vibratory dilation effectively prepares the cervix for the intense prostaglandin‐induced uterine contractions and thereby reduces the risk of cervical laceration and fistula. The dilation of the cervical canal also makes an early low amniotomy possible and easy. This study demonstrates a highly effective, safe and relatively nontraumatic method for uterine evacuation after intrauterine fetal death.

ISSN:0020-6695    

DOI:10.1002/j.1879-3479.1979.tb00159.x

出版商:Wiley    

年代:2016

数据来源: WILEY