摘要:

ABSTRACTThree cases of verrucous carcinoma of the vulva are reported. This variant of epidermoid carcinoma can easily be misdiagnosed if correlation is not made between the clinical and histopathologic appearance. These tumors tend to invade locally and rarely metastasize. Anaplastic transformation has been reported after radiation therapy, making surgical excision the treatment of choice.

ISSN:0020-6695    

DOI:10.1002/j.1879-3479.1980.tb00201.x

出版商:Wiley    

年代:2016

数据来源: WILEY

摘要:

ABSTRACTBetween the years 1958 and 1973, 119 patients with primary invasive cancer of the vulva were treated at the University Hospital of the West Indies, Kingston, Jamaica. Seventy‐seven (64.7%) were premenopausal women. Because the pattern of the disease differed from that in late middle and older aged Jamaican women, the results of the disease are presented. The analysis stresses that vulvar carcinoma before menopause in our community is rare in the absence of various sexually transmitted granulomatous diseases of the vulva.This paper was presented at the 4th Scientific Meeting of the West Indies Section, District IV of the American College of Obstetricians and Gynecologists and the Grabham Society Meeting on Recent Advances in Obstetrics and Gynecology, Kingston, Jamaica, May 17‐18, 1978.

ISSN:0020-6695    

DOI:10.1002/j.1879-3479.1980.tb00202.x

出版商:Wiley    

年代:2016

数据来源: WILEY

摘要:

ABSTRACTSelected studies on the physiology of the perimenopausal years and the subtle transitional changes that occur up to the postmenopause are reviewed. Extraovarian sources of estrogen, which must be considered when recommending dosage of replacement therapy, are described. The effects of hormonal therapy on endogenous hormones and the important roles of progesterone and prolactin are highlighted. The collected evidence suggests that (a) the vasomotor disturbance and depression experienced by estrogen‐deficient women are not psychosomatic disorders, (b) osteoporosis is preventable if estrogen therapy is initiated soon after cessation of ovarian function, and (c) administration of a weak estrogen combined with a progestogen can effectively prevent or treat the difficulties experienced during the female climacteric.

ISSN:0020-6695    

DOI:10.1002/j.1879-3479.1980.tb00203.x

出版商:Wiley    

年代:2016

数据来源: WILEY

摘要:

ABSTRACTThe vaginal hormone cytology and the serum estrogen levels (as determined by radioimmunoassay) of 39 postmenopausal patients were compared. All cytologic parameters showed high statistical correlations with radioimmunoassay values, but these general associations could not be applied to individual patients. A more detailed analysis showed that an atrophic smear (eg, karyopyknotic index [KI],20%; maturation value [MV],<40%) indicate estrogen deficiency in the postmenopause. When the KI is 20%‐40%, the parabasal cells less than 20% or the MV 40%‐60%, the evaluation of estrogen status, on the basis of hormone cytology alone, is indeterminate. The three cytologic indices studied seem much more useful for detecting estrogen deficiency than estrogen excess in the postmenopause. The fact that immunochemical characteristics are not always related to biologic behavior must also be considered when interpreting these findings.

ISSN:0020-6695    

DOI:10.1002/j.1879-3479.1980.tb00204.x

出版商:Wiley    

年代:2016

数据来源: WILEY

摘要:

ABSTRACTSixty postmenopausal women with climacteric symptoms were treated with either clonidine hydrochloride or piperazine estrone sulfate in two different dosage strengths. Neither drug had an adverse effect on serum lipid levels and there was no significant change in the serum cholesterol and triglyceride levels during treatment.

ISSN:0020-6695    

DOI:10.1002/j.1879-3479.1980.tb00205.x

出版商:Wiley    

年代:2016

数据来源: WILEY

摘要:

ABSTRACTLarge vesicovaginal fistulae, particularly those associated with urethral loss, present formidable repair problems. Omentum, recognized for its role in resolving abdominal infection, is successfully used for pedicle grafts in these complex situations. The authors present their experience in 25 cases, describing modifications of an earlier procedure.

ISSN:0020-6695    

DOI:10.1002/j.1879-3479.1980.tb00206.x

出版商:Wiley    

年代:2016

数据来源: WILEY

摘要:

ABSTRACTAlthough female circumcision is a mutilating operation and has been illegal in the Sudan since 1945, it is an old tradition and is still performed on about two thirds of Sudanese women. The three types of female circumcision are described and the gynecologic and obstetric complications experienced by 7505 circumcised women are discussed.

ISSN:0020-6695    

DOI:10.1002/j.1879-3479.1980.tb00207.x

出版商:Wiley    

年代:2016

数据来源: WILEY

摘要:

ABSTRACTEleven cases of septic pelvic thrombophlebitis and persistant fever following cesarean section and cesarean hysterectomy are presented. Addition of heparin to the antibiotic regimen of these patients produced a clinical response within 1‐5 days, except in two patients who developed septic pulmonary emboli, which finally resolved with continued heparin therapy. An incidental finding was a high incidence of pelvic thrombophlebitis following hypogastric artery ligation. The results justify a trial of heparin therapy, before resorting to exploratory laparotomy, in postpelvic surgery patients who have unexplained fever.

ISSN:0020-6695    

DOI:10.1002/j.1879-3479.1980.tb00208.x

出版商:Wiley    

年代:2016

数据来源: WILEY

摘要:

ABSTRACTTwenty‐two women with unexplained heavy menstrual blood loss (average loss for two cycles of>80 ml) were treated with the prostaglandin synthetase inhibitor mefenamic acid during two consecutive menstruations. There was a significant reduction in menstrual blood loss on mefenamic acid therapy, the median loss being 137 ml before treatment and 76 ml while on treatment. Reduction in menstrual loss was achieved in 20 of the 22 patients but varied from a 2% to 78% reduction. The greater the menstrual loss before treatment, the more it was reduced on mefenamic acid therapy. Endometrial concentrations of prostaglandins E2and F2αin the follicular phase of the cycle were similar whether or not patients had menorrhagia. In the luteal phase, however, 6 of 14 patients with menorrhagia had higher endometrial prostaglandin E2and F2αconcentrations than all 13 controls.

ISSN:0020-6695    

DOI:10.1002/j.1879-3479.1980.tb00209.x

出版商:Wiley    

年代:2016

数据来源: WILEY

摘要:

ABSTRACTIn a retrospective study of 163 women with endometriosis, 76% had a history of menorrhagia, a larger percentage than that which might be normally expected. Only 10% of the women complained of infertility, while 13% had used oral contraceptives regularly, a much smaller proportion than expected. These findings are discussed in terms of the pathogenesis of endometriosis and the possible prophylactic role of oral contraceptives. The authors suggest the possibility that increased sensitivity to estrogens may lead to the development of endometriosis in some women.

ISSN:0020-6695    

DOI:10.1002/j.1879-3479.1980.tb00210.x

出版商:Wiley    

年代:2016

数据来源: WILEY