ISSN:0885-6222    

DOI:10.1002/hup.470090601

出版商:John Wiley&Sons, Ltd.    

年代:1994

数据来源: WILEY

摘要:

AbstractAlthough the hallmark of Alzheimer's disease (AD) is memory loss, behavioural and psychiatric disturbances are common and often pose the greatest problems for carers and patients. Modifying behavioural disturbance in AD sufferers can delay institutionalization and improve the quality of life of patient and caregiver. The failure to appreciate the importance of the behavioural and psychiatric disturbances in AD and their impact on the care of patients in the community has resulted in a dearth of services, resources and research into the management of the non‐cognitive aspects of this illnes

ISSN:0885-6222    

DOI:10.1002/hup.470090602

出版商:John Wiley&Sons, Ltd.    

年代:1994

数据来源: WILEY

摘要:

AbstractBilateral removal of the olfactory bulbs in rats produces a behavioural abnormality that is defined by hyperactivity in the open‐field test. This abnormality may be related to depression since these behavioural effects can be attenuated by antidepressant drugs. Moreover, changes in the cholinergic and serotonergic system may be involved in the pathogenesis of depression. Thus, muscarinic cholinergic and serotonin2receptors were measured by quantitative autoradiography after the bilateral removal of the olfactory bulbs from the rat. In OB rats, muscarinic receptor density was decreased in several brain regions including the amygdaloid cortex, the basal ganglia, hippocampus, hypothalamus, cortex and olfactory regions. Serotonin2receptors were increased in all cortical regions, in the hippocampus and the thalamus. When OB rats were treated chronically for 35 days with mianserin (5 mg/kg i. p.) or desipramine (7·5 mg/kg i. p.) the behavioural hyperactivity was reversed and muscarinic receptor density was increased in the hippocampus and cortical regions while serotonin2receptors were normalized. The results are consistent with a cholinergic and serotonin involvement in depressive illness and suggest that the cholinergic and serotonergic modulatory properties of antidepressant drugs may contribute to their therapeutic effectivene

ISSN:0885-6222    

DOI:10.1002/hup.470090603

出版商:John Wiley&Sons, Ltd.    

年代:1994

数据来源: WILEY

摘要:

AbstractIn a controlled, randomized, multicenter, double‐blind study involving 335 patients with generalized anxiety disorder, buspirone (Busp) was compared to lorazepam, diazepam or bromazepam in order to test its global efficacy, preferential effectiveness in defined subgroups of patients or symptoms, latency of action and safety and tolerability. Apart from minor differences, the dropout rate, the number of subjects for whom the dose was increased, the number of capsules taken daily, the modifications of HRSA, VAS 100 mm, CGIS and CGSRS, the curves of improvement over time, the effectiveness on the somatic and psychic factors of the HRSA, the responsiveness of depressed and non‐depressed anxious patients, and the profiles of adverse events indicated clinical equivalence between the azaspirodecanedione and the comparison benzodiazepi

ISSN:0885-6222    

DOI:10.1002/hup.470090604

出版商:John Wiley&Sons, Ltd.    

年代:1994

数据来源: WILEY

摘要:

AbstractSixty‐seven patients meeting DSM‐III‐R criteria for schizophrenia who had been eligible for a placebo controlled trial of an antipsychotic preparation were followed up at 9 months to examine whether a variety of socio‐demographic, illness, treatment and compliance variables were associated with consent to participate in the treatment trial. A survey of subjective appraisals concerning the trial and attitudes to medication of trial participants was also carried out.The data revealed that the non‐consenting patients had similar lengths of illness histories to those consenting but had experienced fewer previous psychiatric hospital admissions. The non‐consenting group had been less compliant with their overall treatment in the follow‐up period. More consenting patients were inpatients or day patients (rather than outpatients) at follow‐up and as a group, they were receiving significantly more medication than non‐consenting patients. They also exhibited more extrapyramidal and abnormal involuntary movements than the non‐consenting group.Our results do not support a direct relationship between severity of illness and the likelihood to consent to this type of research. The highly selective nature of samples of patients entering research is highlighted and the generalizability of results of similar drug studies may ther

ISSN:0885-6222    

DOI:10.1002/hup.470090605

出版商:John Wiley&Sons, Ltd.    

年代:1994

数据来源: WILEY

摘要:

AbstractThe beta‐2‐adrenoceptor agonist salbutamol, widely used in the treatment of asthma, is thought to have antidepressant activity and possibly an abuse liability. In order to examine the mood‐altering potential of this drug, a placebocontrolled, double‐blind crossover trial was conducted in 21 psychiatrically normal subjects. The Profile of Mood States (POMS) was used to assess mood at baseline, after six weeks of placebo and salbutamol treatment (in either order), and after a four‐week washout period in between treatments. The results showed little difference between treatments, apart from a tendency for salbutamol to worsen subjective mood relative to placebo during the first treatment phase only. In conclusion, the blinded, placebo‐controlled administration of salbutamol gives no evidence of mood‐elevating or addictive properties in psychiatrically norma

ISSN:0885-6222    

DOI:10.1002/hup.470090606

出版商:John Wiley&Sons, Ltd.    

年代:1994

数据来源: WILEY

摘要:

AbstractWe describe two patients with parkinsonism and depressive symptoms who experienced a worsening of their motor disturbances following use of fluvoxamine, a serotonin selective reuptake inhibitor. The possible role of this drug in causing these adverse effects is discussed in the light of the complex serotonin‐dopamine interactions in the brai

ISSN:0885-6222    

DOI:10.1002/hup.470090607

出版商:John Wiley&Sons, Ltd.    

年代:1994

数据来源: WILEY

ISSN:0885-6222    

DOI:10.1002/hup.470090608

出版商:John Wiley&Sons, Ltd.    

年代:1994

数据来源: WILEY

ISSN:0885-6222    

DOI:10.1002/hup.470090609

出版商:John Wiley&Sons, Ltd.    

年代:1994

数据来源: WILEY

ISSN:0885-6222    

DOI:10.1002/hup.470090610

出版商:John Wiley&Sons, Ltd.    

年代:1994

数据来源: WILEY