摘要:

SUMMARYThe Fourth International Workshop on Chromosome 9 was a highly successful endeavor in terms of the growth of the map, both genetic and physical, the amount of data entered into GDB, and the continued comradeship in the sharing of data and resources that was exemplified. SIGMA remained a stable and valuable part of the chromosome 9 mapping effort. A new subsection outlining the morbid anatomy of chromosome 9 was included. Finally, specific goals were set for the community to aim for over the upcoming months. These included extending the information about the ease of use of genetic markers, and coordinating across numerous groups the meiotic breakpoint mapping of many microsatellite markers. Workshop files are available by anonymous ftp from ftp.gene.ucl.ac.uk (128.40.82.1) in the subdirectory /pub/c9workshop/1995, or by using a World Wide Web browser (such as Mosaic or Netscape) via the Chromosome 9 Home Page (at the URLhttp:www.gene.ucl.ac.ukchr9home.html).

ISSN:0003-4800    

DOI:10.1111/j.1469-1809.1995.tb00756.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

ISSN:0003-4800    

DOI:10.1111/j.1469-1809.1995.tb00757.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

SUMMARYAn integrated map of 211 loci on chromosome 9 is presented for which 198 loci have genetic locations. The results of the analysis indicate very strong interference for the chromosome and positional variations in recombination rates, most extreme in the male map where there is an excess of recombination near the p telomere and a marked suppression of recombination in a large region that includes the centromere.

ISSN:0003-4800    

DOI:10.1111/j.1469-1809.1995.tb00758.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

SUMMARYWe have typed three markers on proximal 11q in 131 random families with three or more children studied for atopy. A summary map that includes the FCER1B candidate was constructed. Using a 2‐locus disease model, we performed combined segregation and linkage analysis of three models, none of which suggested linkage. Nine marker loci on other chromosomes were also negative. In the regions swept by these 12 markers we cannot rule out a rare gene, perhaps of large effect, nor a common gene of small effect. However, a common gene of large effect is excluded. These results and alternative strategies are discussed in the perspective of inconsistent evidence for a major atopy gen

ISSN:0003-4800    

DOI:10.1111/j.1469-1809.1995.tb00759.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

SUMMARYA framework genetic map of human chromosome 2 is described, integrating data from the Centre d'Étude du Polymorphisme Humain (CEPH) version 6 database, the CEPH chromosome 2 consortium database, the National Institute of Health (NIH)/CEPH Collaborative Mapping group and other laboratories. A comprehensive map is also presented, showing regional locations of a large number of additional loci. The framework map is used to identify an informative set of meiotic breakpoints within the CEPH families, and the utility of this information for mapping new markers is discussed. The degree of typing error within the data set is estimated, as are the sex‐specific interference parameters. A location database for these genetic and additional cytogenetic data is constructed using algorithms which map genetic distances on to a physical scale, and the potential for this approach to aid the integration of genetic and physical data is examin

ISSN:0003-4800    

DOI:10.1111/j.1469-1809.1995.tb00760.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

SUMMARYThe Maximum Lod Score method for affected relative‐pair analysis, introduced by Risch, is a powerful method for detecting linkage between an autosomal marker locus and disease. In order to use the method to detect linkage to markers on the X‐chromosome, some modification is necessary. Here we extend the method to be applicable to X‐chromosomal data, and derive genetic restrictions on the haplotype‐sharing probabilities analogous to the ‘possible triangle’ restrictions described by Holmans for the autosomal case. Size criteria are derived using asymptotic theory and simulation, and the power is calculated for a number of possible underlying models. The method is applied to data from 284 type 1 diabetic families and evidence is found for the presence of one or more diabetogenic loci on the X

ISSN:0003-4800    

DOI:10.1111/j.1469-1809.1995.tb00761.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

ISSN:0003-4800    

DOI:10.1111/j.1469-1809.1995.tb00762.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

Cystic Fibrosis ‐ Current Topics, vol. 2. Edited by J. A. Dodge, D. J. H. Brockand J. H. Widdicombe.The Molecular Genetics of Haemostasis and its Inherited Disorders. Oxford Monographs on Medical Genetics, No. 25.By E. G. D. Tuddenhamand D. N. Coope

ISSN:0003-4800    

DOI:10.1111/j.1469-1809.1995.tb00763.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY