G Omenn,
G Goodman,
J Grizzle,
M Thornquist,
L Rosenstock,
S Barnhart,
G Anderson,
J Balmes,
M Cherniack,
J Cone,
M Cullen,
A Glass,
J Keog,
F Meysken,
B Valanis,
CARET is a two-armed, double-blind, randomized chemo-prevention trial to test the hypothesis that oral administration of beta-carotene 30 mg/day plus retinyl palmitate 25 000 IU/day will decrease the incidence of lung cancer in high-risk populations: heavy smokers and asbestos-exposed workers who have smoked. The agents combine anti-oxidant and nuclear tumor suppressor mechanisms. Fastidious monitoring for possible side effects is facilitated by inclusion of a Vanguard population. As of 31 December 1990, 6 105 participants of the 18 000 needed have been randomized in the trial. Efficacy results are expected in 1999.
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Volume 2 issue 1
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