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The role of glucocorticoids in the treatment of fulminant hepatitis induced by dacarbazine |
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Anti-Cancer Drugs,
Volume 13,
Issue 2,
2002,
Page 177-179
Yair Herishanu,
Michael Lishner,
Yona Kitay-Cohen,
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摘要:
Dacarbazine (DTIC) is commonly used for the treatment of malignant melanoma and Hodgkin's disease. A very rare complication of this cytotoxic agent is acute vascular hepatic damage, e.g. veno-occlusive disease or Budd–Chiari syndrome. The pathophysiological mechanism involved seems to be an immune reaction. This complication is frequently fatal. We report a patient who developed severe hepatic failure following DTIC treatment who responded favorably to treatment with glucocorticosteroid.
ISSN:0959-4973
出版商:OVID
年代:2002
数据来源: OVID
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