摘要:

The object of this study was to measure how accurately drinkers report their consumption of alcohol. Twenty‐two normal volunteers kept a written record of all alcoholic beverages they consumed in 1 week. During the same period, their actual intake was monitored by the sweat‐patch test for alcohol consumption. Only nine subjects (40.9%) reported their alcohol consumption accurately; two (9.1%) overreported their intake, and 11 (50%) underreported their intake. Five (22.7%) of those who underreported their consumption claimed to have drunk no alcohol at all, but elevated ethanol levels in their sweat‐patch tests indicated otherwise. These data suggest that self‐reported claims concerning alcohol consumption or abstinence should be received with a degree of skepticism, and that greater emphasis should be placed upon objective laboratory tests for the diagnosis of alcoho

ISSN:0145-6008    

DOI:10.1111/j.1530-0277.1984.tb05032.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

Although acute perfusion of guinea pig hearts with ethanol does not affect cardiac protein synthesis, the latter is inhibited after prolonged ingestion of ethanol when tested in an in vitro system with the working right ventricle. This study reports on the added stress of ischemia on such hearts. Hearts were removed from maturing guinea pigs after 13–16 weeks of ingesting 10% ethanol and were perfused in vitro under conditions of relative ischemia (one‐sixth of normal coronary flow) with maintenance of right ventricular load and outflow resistance identical to normal pre‐ischemic levels. With this degree of ischemia, there was a 4–6 fold increase in lactate production, an 80% drop in ATP, and a 90% decrease in creatine phosphate after 150 min of the ischemia. Incorporation of both labeled lysine and phenylalanine into cardiac protein was also diminished to 35% of control in the left ventricle and 55% of control in the right This diminution of protein synthesis was the same in hearts from ethanoJ‐drinking and matched control animals. Thus, prior prolonged ingestion of ethanol old not worsen the inhibition of protein synthesis by oxygen deprivation. There were, however, two significant differences in hemodynamic response to the ischemia by the right ventricles of hearts from ethanol‐drinking guinea pigs compared to their matched controls. The first was a decreased ability of the ventricles to maintain the same peak systolic pressure as the controls during ischemia (4.8 ± 0.8 mm Hg compared to 7.5 ± 0.06, p<0.02), and the second was a significant increase in coronary resistance in hearts from ethanol‐drinking animals as the ischemic perfusion progressed (coronary pressure 23.6 ± 1.3 mm Hg compared to 17.0 ± 0.8 in controls, p<0.001). The findings suggest that although contractility of hearts from ethanol‐consummg animals may not show impairment of contraction under normal conditions, the imposition of another stress such as ischemia may expose a con

ISSN:0145-6008    

DOI:10.1111/j.1530-0277.1984.tb05033.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY