ISSN:0265-9247    

DOI:10.1002/bies.950110502

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY

摘要:

AbstractThe body plan of the frog is set‐up by a rearrangement of the egg cytoplasm shortly after fertilization. Microtubules play several roles in this critical developmental even

ISSN:0265-9247    

DOI:10.1002/bies.950110503

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY

摘要:

AbstractAll eukaryotic cellular mRNAs, and most viral mRNAs, are blocked at their 5′ ends with a cap structure (m7GpppX, where × is any nucleotide). Poliovirus, along with a small number of other animal and plant viral mRNAs, does not contain a 5′ cap structure. Since the cap structure functions to facilitate ribosome binding to mRNA, translation of poliovirus must proceed by a cap‐independent mechanism. Consistent with this, recent studies have shown that ribosomes can bind to an internal region within the long 5′ noncoding sequence of poliovirus RNA. Possible mechanisms for cap‐independent translation are discussed. Cap‐independent translation of poliovirus RNA is of major importance to the mechanism of shut‐off of host protein synthesis after infection. Moreover, it is likely to play a role in determining poliovirus neurovirulence a

ISSN:0265-9247    

DOI:10.1002/bies.950110504

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY

摘要:

AbstractNatural selection in the laboratory has been used to produce populations ofDrosophilawith genetically increased lifespan. These populations have been used to determine the physiological basis of postponed ageing and its pleiotropic concomitants. It appears that many loci and a number of physiological alterations are involved in increased lifespan.

ISSN:0265-9247    

DOI:10.1002/bies.950110505

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY

摘要:

AbstractThe preceding five years have brought remarkable advances in our understanding of the primary structure of drug receptors. The roles of certain amino acid residues in binding drugs and effecting receptor function have been proposed. As even more detailed structures become available, the goal of rational design of drug molecules based on predicted fits between the drug and its receptor will be near at hand. Although none of the classical receptors has yet yielded to X‐ray crystallographic analysis, the methods of molecular biology facilitate the production of the large amounts of these rare proteins necessary for crystallization. Receptor proteins share one fundamental characteristic with allosterically regulated enzymes. Both have the structural flexibility that allows information to be transmitted to distant parts of the molecule. We will discuss recent observations about receptor structure and the dynamic nature of drug receptors, and pose questions about the significance of receptor dynamics for drug desig

ISSN:0265-9247    

DOI:10.1002/bies.950110506

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY

摘要:

AbstractIt has long been thought that the central nervous system is able to influence the progression of disease. Furthermore, there is now overwhelming evidence that the communication pathways are bidirectional. A variety of immune system peptides are now known to be capable of transmitting information from the immune system to the central nervous system. These immunotransmitters include interleukins, interferons and thymosine peptides which have the capability of modulating slow‐wave sleep as well as the release of neuro‐ and pituitary peptides. In some instances, release of these peptides during early development may have long lasting, if not permanent effects upon the normal development of neuro‐endocrine circuits. Collectively these various brain mediated events appear to contribute in various and diverse ways to defense against pathogens. It is becoming more and more apparent that certain abnormalities within the immune system may be the consequence of a neurological abnormality. The converse is also

ISSN:0265-9247    

DOI:10.1002/bies.950110507

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY

摘要:

AbstractRetinoic acid is a good candidate for a morphogen in chick limb bud development. The challenge now is to determine how retinoic acid interacts with limb bud cells and how the retinoic acid signal is integrated with other signals to mould and pattern the developing limb.

ISSN:0265-9247    

DOI:10.1002/bies.950110508

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY

ISSN:0265-9247    

DOI:10.1002/bies.950110509

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY

ISSN:0265-9247    

DOI:10.1002/bies.950110510

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY

ISSN:0265-9247    

DOI:10.1002/bies.950110511

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY