ISSN:0265-9247    

DOI:10.1002/bies.950110102

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY

摘要:

AbstractAt anaphase chromosomes move to the spindle poles (anaphase A) and the spindle poles move apart (anaphase B).In vitrostudies using isolated diatom spindles demonstrate that the primary mechano‐chemical event responsible for spindle elongation is the sliding apart of half‐spindle microtubules. Further, these forces are generated within the zone of microtubule overlap in the spindle midz

ISSN:0265-9247    

DOI:10.1002/bies.950110103

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY

摘要:

AbstractThe transition from mitotic cell division to meiosis in yeast is governed by both the mating‐type genes and signals from the environment. Analysis of mutants that are unable to regulate entry into meiosis has identified many genes that function in this process and in some cases, the biochemical activity of their protein products has been described. At least two of the the mating‐type genes ofSaccharomyces cerevisiaeencode DNA binding proteins that regulate transcription of unlinked genes required for entry into meiosis. Meiotic development of the distantly related yeast,Schizosaccharomyces pombe, is also controlled by the mating‐type genes but in this yeast, their role is to regulate expression of a protein that acts as an inhibitor of a protein kinase. The ability to use the powerful tool of genetics in yeast has provided us with many new insights into the problem of meiotic develo

ISSN:0265-9247    

DOI:10.1002/bies.950110104

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY

摘要:

AbstractThe formation of a highly condensed chromosome structure (heterochromatin) in a region of a eukaryotic chromosome can inactivate the genes within that region. Genetic studies using the fruitflyDrosophila melanogasterhave identified several essential genes which influence the formation of heterochromatin. My purpose in this review is to summarize some recent work on the genetics of heterochromatin assembly inDrosophilaand a recent model for how chromosomal proteins may interact to form a heterochromatic structure.

ISSN:0265-9247    

DOI:10.1002/bies.950110105

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY

摘要:

AbstractSmooth muscle cells squeeze the blood back to your heart, raise the hackles on your neck and change the F‐stop of your eyes. The past year has provided penetrating new insights into their mechanism of contractio

ISSN:0265-9247    

DOI:10.1002/bies.950110106

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY

摘要:

AbstractThe expression of products encoded by the major histocompatibility complex (MHC) on tumor cells has recently been studied extensively. It has been found that many malignant tumor cells have their MHC antigens ‘switched‐off’ but that these antigens are re‐expressed following DNA‐mediated gene transfer, with increased tumor immunogenicity as a result and the consequence that these ‘transformed’ tumor cells are rejected invivo.: This review will discuss approaches that have been taken to induce strong tumor‐specific immunity by the manipulation of MHC expression

ISSN:0265-9247    

DOI:10.1002/bies.950110107

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY

摘要:

AbstractThe levels of different classes of mitochondrially encoded transcripts are developmentally regulated in sea urchin embryos, as a result of selection between mutually exclusive synthetic pathways. I propose a simple model to explain these observations, based on a dual role for mitochondrial ribosomes and translation factors in RNA synthesis as well as in translation. This effect may be exerted either at the transcriptional or post‐transcriptional level (or both), and is potentially generalizable to mammalian mtDNA and to other system

ISSN:0265-9247    

DOI:10.1002/bies.950110108

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY

摘要:

AbstractThe following is a report of a meeting of the British Society for Cell Biology on ‘The Cell Cycle’, at St Andrews University, 4‐6 April,

ISSN:0265-9247    

DOI:10.1002/bies.950110109

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY

ISSN:0265-9247    

DOI:10.1002/bies.950110110

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY

ISSN:0265-9247    

DOI:10.1002/bies.950110101

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY