ISSN:0265-9247    

DOI:10.1002/bies.950020302

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

摘要:

AbstractThe transmission of electrical impulses in nerve and muscle cells depends fundamentally on the operation of specific ion channels in their membranes. Recent technical advances in electrical recording from cell membranes have permitted the analysis of the properties of single ion channels and the measurement of gating currents. The results have revealed considerable complexities, in particular in the operation of voltage‐gated sodium channels, and in the relationships between the several open and closed states of the channels. An important new development is the cloning and analysis of the structural genes for the acetylcholine receptor and sodium channel protein, which promises to yield fresh insights into the functioning of these protein

ISSN:0265-9247    

DOI:10.1002/bies.950020303

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

摘要:

AbstractStem cells may have a special importance in the neoplastic behavior of certain lineages as well as in the normal development of these tissues. The role of oncogenes, and their normal cellular analogues, in stem cell behavior is therefore of special interest. This review describes recent results on the effects of virally‐mediated src‐gene transfer into hemopoietic stem cells in the physiological and developmental properties of these ce

ISSN:0265-9247    

DOI:10.1002/bies.950020304

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

摘要:

AbstractCurrent research into the molecular biology of blood‐clotting factors suggests that the basis of inherited bleeding disorders may soon be understood. In addition, the expression of cloned genes for the factors in mammalian cell lines provides the hope of pure factors being available for replacement therapy, uncontaminated with the causative agents for Hepatitis and Acquired Immune Deficiency Syndrome (AIDS), identified in the blood products at present available. The recent findings on the molecular biology of several of the key blood clotting genes are described her

ISSN:0265-9247    

DOI:10.1002/bies.950020305

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

摘要:

AbstractThe second messenger molecules cAMP and Ca2+regulate a large number of eukaryotic cellular events. cAMP acts on protein kinases and Ca2+works through a ubiquitous calcium‐binding protein, calmodulin. The two systems are not independent, however, but interact in several important fashions. These interactions, and, in particular, the modulation of the cAMP signal by two Ca2+/calmodulin‐regulated proteins, cyclic nucleotide phosphodiesterase and calcineurin, are described h

ISSN:0265-9247    

DOI:10.1002/bies.950020306

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

摘要:

AbstractOur understanding of the sphingolipidoses has improved as a result of the investigation of molecular mechanisms causing clinical heterogeneity. This knowledge, derived from both the protein and gene structures, should bring therapy for these inherited disorders closer to a realistic possibility.

ISSN:0265-9247    

DOI:10.1002/bies.950020307

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

摘要:

AbstractSince their introduction about ten years ago the rapid methods for sequencing DNA based either on selective chemical degradation1or primed enzymatic synthesis2have been subject to a number of modifications and improvements.3, 4Two recently published papers describe further advances in these technologies: a method for obtaining information about DNA sequences directly from uncloned mammalian genomic DNA5and a possible first step towards the automation of DNA sequencing6.

ISSN:0265-9247    

DOI:10.1002/bies.950020308

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

ISSN:0265-9247    

DOI:10.1002/bies.950020309

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

ISSN:0265-9247    

DOI:10.1002/bies.950020310

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

ISSN:0265-9247    

DOI:10.1002/bies.950020311

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY