摘要:

AbstractGap junctions are ubiquitous plasma membrane specializations that allow cells to exchange small molecules and ions directly. The isolation, biochemical characterization and molecular cloning of the major protein of rat liver gap junctions lead to a clearer view of these membrane zones that allow cells to ‘talk’ to each other and co‐ordinate their activities in tissues and o

ISSN:0265-9247    

DOI:10.1002/bies.950080102

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1988

数据来源: WILEY

摘要:

AbstractWhile evidence for the role of gap functions, particularly during development, has been mounting, it has remained largely correlative, linking structure with presumed functions. With the recent advent of functional antibodies raised to the junctional protein, however, it has become possible to study the role of gap junctions more directly. There is now considerable evidence indicating that they play a vital role in tissue pattern formation and differentiation by allowing direct cell‐to‐cell transfer of developmental signals or morphog

ISSN:0265-9247    

DOI:10.1002/bies.950080103

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1988

数据来源: WILEY

摘要:

AbstractInterferon (IFN) induced during a virus infection mediates antiviral effects both by direct inhibition of virus replication and by influencing the proliferation, differentiation, and chemotaxis of cyto‐toxic lymphocytes which control the infection. Cells from tissue taken from virus‐infected mice are conditioned by IFN to resist lysis by natural killer (NK) cells, while they become increasingly susceptible to lysis by cytotoxic Tlymphocytes (CTL). This is due to marked IFN‐induced biochemical changes, including an up‐regulation of major histocompatibility antigens, which are targets for CTL. Cytopathic viruses, which inhibit cellular RNA and protein synthesis, render target cells refractory to IFN‐mediated protection against NK cells, thereby providing a mechanism for NK cells to mediate antiviral effect by preferentially lysing virus‐infected but not uninf

ISSN:0265-9247    

DOI:10.1002/bies.950080104

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1988

数据来源: WILEY

摘要:

AbstractIt has long been known that the red blood cell contains a membrane skeleton that stabilizes the plasma membrane, determines its shape, and regulates the lateral distribution of the membrane glyco‐proteins to which it is attached. The way in which these functions are regulated in other cells has not been understood. It has now been shown that platelets also contain a membrane skeleton. In contrast to the membrane skeleton of the red blood cell, the platelet membrane skeleton has actin‐binding protein, not spectrin, as a major component. The platelet membrane skeleton regulates the same cellular functions as the red blood cell membrane skeleton. Other cells may contain a membrane skeleton that is critical to their viability and normal function

ISSN:0265-9247    

DOI:10.1002/bies.950080105

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1988

数据来源: WILEY

摘要:

AbstractTheovarian tumor (otu)gene behaves as if it encodes a product (OGP) which is required during several early steps in the transformation of oogonia into functional oocytes. The ovarian phenotypes produced by various EMS‐induced mutations can be explained as graded responses by individual mutant germ cells to the different levels of functionally active OGP they themselves synthesize. In addition, genetic evidence suggests thatotualso encodes a second product that is utilized late in oogenesis. Molecular studies of theotugene demonstrate that it does transcribe at least two ovaryspecific RNAs. The possible function of theotuproduct in the cellular divisions that give rise to the oocyte and its sister nurse cells is discusse

ISSN:0265-9247    

DOI:10.1002/bies.950080106

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1988

数据来源: WILEY

摘要:

AbstractThe study of adhesion plaques in normal and transformed cells provides a series of phenotypic markers by which the process of transformation can be followed. Several proteins which are concentrated in adhesion plaques have now been identified; a few of these can act as targets for tyrosine kinase. In an attempt to characterize the relationship between tyrosine phosphorylation and cell transformation, the reactions of three such proteins – vinculin, talin and integrin – with a range of tyrosine kinase oncogene products have been studied in det

ISSN:0265-9247    

DOI:10.1002/bies.950080107

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1988

数据来源: WILEY

摘要:

AbstractMetal ions may play an essential role in chromatin organization and, thus, be main actors in the gene expression drama. A model is proposed here for the interaction of DNA‐binding transcriptional regulatory proteins with histone H3 via coordinated metal ions and discussed in relation to the conversion of nucleosomal ‘closed’ to ‘open

ISSN:0265-9247    

DOI:10.1002/bies.950080108

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1988

数据来源: WILEY

ISSN:0265-9247    

DOI:10.1002/bies.950080109

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1988

数据来源: WILEY

ISSN:0265-9247    

DOI:10.1002/bies.950080110

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1988

数据来源: WILEY

ISSN:0265-9247    

DOI:10.1002/bies.950080111

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1988

数据来源: WILEY