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Synthesis and Antiproliferative Activity of 6‐Ferrocenyl‐3‐Substituted 7H‐1,2,4‐Triazolo[3, 4‐b]‐1,3,4‐Thiadiazines |
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Journal of the Chinese Chemical Society,
Volume 56,
Issue 1,
2009,
Page 214-218
Yin Han,
Qin Wang,
Yu‐Ping Du,
Ming‐Hua Lv,
Xin‐Ping Hui,
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摘要:
AbstractFive new 6‐ferrocenyl‐3‐substituted 7H‐1,2,4‐triazolo[3, 4‐b]‐1,3,4‐thiadiazines (3a‐e) have been synthesized and characterized on the basis of elemental analyses and spectral data. The antiproliferative activities were examined in two human cell lines (BJ and HT 1080) with the acid phosphatase assay. The results showed that all compounds could reduce cell viability. The significant difference between the two cell lines was that fibrosarcoma HT 1080 cells could indeed be more susceptible to the compounds than the normal fi
ISSN:0009-4536
DOI:10.1002/jccs.200900031
出版商:WILEY‐VCH Verlag
年代:2009
数据来源: WILEY
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