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11. |
Genetic predisposition to skin cancer |
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Current Opinion in Oncology,
Volume 11,
Issue 2,
1999,
Page 132-132
Allan Halpern,
Jamie Altman,
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摘要:
Here we review recent insights in the genetics of skin cancer susceptibility as gleaned from studies of three hereditary syndromes: basal cell nevus syndrome, familial melanoma/dysplastic nevus syndrome, and xeroderma pigmentosum. We provide a brief synopsis of the recent findings related to these syndromes in an attempt to illustrate several emerging themes in the genetics of skin cancer. These themes include 1) the recent identification of multiple cancer susceptibility genes that occur in a myriad of cellular regulatory pathways; 2) the relative specificity of certain regulatory pathways to the development of specific types of cancer; and 3) the important role of DNA damage caused by ultraviolet radiation and defective DNA repair mechanisms in the development of skin cancer. We also review the implications of this knowledge to clinical practice relative to risk assessment, primary prevention, and therapy.
ISSN:1040-8746
出版商:OVID
年代:1999
数据来源: OVID
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12. |
Cutaneous manifestations of cancer |
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Current Opinion in Oncology,
Volume 11,
Issue 2,
1999,
Page 139-139
Smeena Sabir,
William James,
Lynn Schuchter,
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摘要:
The appearance of skin lesions in patients with occult or obvious malignancy may be of extreme value in the detection and management of cancer because the skin is readily accessible to examination and biopsy. Examination of the skin of our patients can provide important insights into underlying malignant processes or possible complications from cancer treatment. The range of cutaneous abnormalities is wide, and include cutaneous paraneoplastic syndromes such as xanthomas, acanthosis nigricans, carcinoid syndrome, unusual erythematous eruptions such as erythema gyratum repens, and a number of genetic syndromes associated with malignancies and inherited dermatoses.
ISSN:1040-8746
出版商:OVID
年代:1999
数据来源: OVID
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13. |
Erratum |
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Current Opinion in Oncology,
Volume 11,
Issue 2,
1999,
Page 145-145
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ISSN:1040-8746
出版商:OVID
年代:1999
数据来源: OVID
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