摘要:

AbstractA patient with moderate splenomegaly and the leukemic phase of hairy cell leukemia presented with a white blood cell count (WBC) of 85,600/mm3with 87% hairy cells and platelets of 125,000/mm3. Initial therapy consisted of chlorambucil alone at 4 mg each day. Within 6 months, the WBC decreased to 27,000/mm3with 82% hairy cells, and the spleen was not palpable; platelets remained at 142,000/mm3. The patient has continued to do well for 2 years since the start of therapy, requiring no transfusions and having no problems secondary to organ infiltration. Selected hairy cell patients, those with a significant leukemic phase and with only mild thrombocytopenia, may benefit from initial chlorambucil therapy rather than immediate splenectomy.

ISSN:0361-8609    

DOI:10.1002/ajh.2830160112

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

摘要:

AbstractA case of agranulocytosis in an 86‐year‐old man after 8 weeks treatment with quinidine sulfate is described. Acute phase serum from the patient demonstrated antineutrophil activity by the microgranulocytotoxicity assay. Review of the literature reveals that more than one mechanism could cause this idiosyncratic immune‐mediated agranulocy

ISSN:0361-8609    

DOI:10.1002/ajh.2830160113

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

摘要:

AbstractPhiladelphia chromosome (Ph1) positive, or “adult‐type,” chronic granulocytic leukemia (CGL) differs in many clinical and laboratory aspects from PH1‐negative, or “juvenile,” CGL. Because of these differences, the disorders have been considered two distinct disease entities. We present a child with Ph1‐positive CGL whose disease has several features more characteristic of the Ph1‐negative syndrome. This case demonstrates that the chromosomal anomaly in CGL is not always predictive of phenotypic expression

ISSN:0361-8609    

DOI:10.1002/ajh.2830160114

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

ISSN:0361-8609    

DOI:10.1002/ajh.2830160116

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

ISSN:0361-8609    

DOI:10.1002/ajh.2830160117

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

ISSN:0361-8609    

DOI:10.1002/ajh.2830160101

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY