摘要:

AbstractWe describe a case of human T‐lymphotropic virus type I (HTLV‐I)‐associated transient benign immature T‐cell lymphocytosis in a black female patient, which over the course of several months underwent spontaneous complete remission. The patient presented with a white blood cell count of 20,000/μl and a T4/T8 ratio of 1.7:1. The majority of cells appeared to be lymphoid in origin, and cell marker analyses established that the circulating lymphocytes were predominantly immature T‐cells. HTLV‐I was detected at this time by a p19 indirect immunofluorescent slide assay. Over a 1‐month period of time the patient's clinical status evolved into a mature T‐lymphocytosis with a T4/T8 ratio of 4.5:1. HTLV‐I was detected by anti‐p19 immunofluorescence by cell sorter analyses and by dot‐bloc nucleic acid hybridization. Serological testing demonstrated that the patient had anti‐HTLV‐I antibodies and antimembrane antibodies specific for an HTLV‐I producing cell line. In a competitive HTLV‐I ELISA assay only HTLV‐I proteins could effectively compete out the seroreactivity. The patient also had a high serum level of soluble interleukin‐2 (IL‐2) receptors, which is associated with HTLV‐I infection. This is the first reported case of immature T‐lymphocytosis in a patient infected with HTLV‐I. The patient's HTLV‐I markers disappeared with time, and her lymphocytosis subsequently spontaneously resolved. She remains disease free and vir

ISSN:0361-8609    

DOI:10.1002/ajh.2830270112

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1988

数据来源: WILEY

摘要:

AbstractTwo female patients in the chronic phase of CML were found to have, in addition to t(9;22), a new karyotypic abnormality—t(3;21)(q26;q22)—present in bone marrow cells. At diagnosis, this abnormality was observed in a small number of marrow cells in both patients, and as the disease progressed in patient 1, the percentage of cells showing t(3;21) was increased, reaching 100% as the transformation to blast crisis occurred. These observations suggest that t(3;21) may represent a new and rare nonrandom rearrangement which may be identified prior to the onset of blast cri

ISSN:0361-8609    

DOI:10.1002/ajh.2830270113

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1988

数据来源: WILEY

摘要:

AbstractA patient with advanced hairy cell leukemia initially had a short‐lived minor response to interferon alpha therapy and failed to respond to interferon gamma. Subsequent treatment with 2′‐deoxycoformycin (dCF) administered biweekly for 12 wk resulted in a complete hematological remission which has continued for 16 months without additional th

ISSN:0361-8609    

DOI:10.1002/ajh.2830270114

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1988

数据来源: WILEY

摘要:

AbstractA 23‐year‐old female presented with widespread purpura and ecchymoses as a result of immune thrombocytopenia which was refractory to corticosteroids, splenectomy, and immunosuppressive agents. In view of the extent and serious nature of her bleeding, salvage therapy with etoposide‐loaded platelets was undertaken, which was associated with a lasting complete remi

ISSN:0361-8609    

DOI:10.1002/ajh.2830270115

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1988

数据来源: WILEY

摘要:

AbstractA patient with acute hyperleukocytotic myelogenous leukemia who presented with acute respiratory distress is reported. Clinical manifestations included dyspnea, tachypnea, hyperventilation, and cyanosis. Blood gas analysis revealed hypoxemia, hypocapnia, and metabolic acidosis. Chest X‐ray and perfusion lung scanning were normal. Pulmonary leukostastis syndrome (PLS) was later confirmed at autopsy. In a patient with hyperleukocytosis from acute nonlymphocytic leukemia and respiratory distress, a normal perfusion lung scintigraph should make one consider the PL

ISSN:0361-8609    

DOI:10.1002/ajh.2830270116

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1988

数据来源: WILEY

摘要:

AbstractThe benefit of oxygen (O2) therapy in non‐hypoxic sickle cell patients in painful crisis is uncertain. We report a case of a non‐hypoxic sickle cell patient in painful crisis who developed marrow red cell hypoplasia requiring transfusion support after O2therapy. The uncertain benefits of O2use in such cases must be weighed against the serious and underrecognized risks of transfusion. In patients who develop O2‐induced marrow red cell hypoplasia, cessation of O2therapy may reverse the anemia and obviate the need for transf

ISSN:0361-8609    

DOI:10.1002/ajh.2830270117

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1988

数据来源: WILEY

摘要:

AbstractCytogenetic studies in a case of acute nonlymphocytic leukemia, type M4‐FAB with eosinophilia, showed an acquired abnormal karyotype characterized by both a t(9;22) Philadelphia translocation and a pericentric Inversion of chromosome 16, inv(16)(p13q22). This unique case shows that the previously described association between inversion of chromosome 16 and myelomonocytic leukemia with bone marrow eosinophilia is true also in Philadelphia‐positive disorders.The present findings are consistent with the existence of a group of chromosome anomalies, namely t(15;17) and inv(16), which are specifically associated with one single stage of morphological differentiation of myeloid leukemic ce

ISSN:0361-8609    

DOI:10.1002/ajh.2830270118

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1988

数据来源: WILEY

ISSN:0361-8609    

DOI:10.1002/ajh.2830270119

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1988

数据来源: WILEY

ISSN:0361-8609    

DOI:10.1002/ajh.2830270120

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1988

数据来源: WILEY

ISSN:0361-8609    

DOI:10.1002/ajh.2830270101

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1988

数据来源: WILEY