摘要:

AbstractA 10‐week‐old girl without Down syndrome developed an acute megakaryoblastic leukemia (AMKL). Bone marrow aspirates and biopsy showed megakaryoblastic infiltration with myelofibrosis. The diagnosis was made based on the findings that the positive reactions of leukemic cells to platelet peroxidase and to monoclonal antibodies which recognize platelet‐specific surface glycoprotein (GP) Ilb/IIIa and GP78. The blasts also showed myeloid and monocytoid differentiation antigens. The leukemic cells had a karyotype of 46,XX,t(1;22)(p13;q13). Our case and two other infantile cases reported by other investigators establish the novel association of the t(1;22) with

ISSN:0361-8609    

DOI:10.1002/ajh.2830390112

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1992

数据来源: WILEY

摘要:

AbstractWe treated 29 patients with chronic‐phase and accelerated chronic myeloid leukemia (CML) with α‐interferon in a dose of 2 mU/m2given subcutaneously daily for 30 days and then three times per week. Most had received prior treatment. Three patients have had sustained hematologic and karyotypic remissions after a median of 22 months of treatment. Three further patients have had complete hematologic and partial karyotypic remissions. At a median follow‐up of 48 months, the median survival has not been reached. This dose of α‐interferon may induce sustained remissions even in pretreated patients and may prolong surviv

ISSN:0361-8609    

DOI:10.1002/ajh.2830390113

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1992

数据来源: WILEY

摘要:

AbstractExpression of mRNAs encoding the erythroid‐specific δ‐aminolevulinate synthase (ALAS‐E) and the nonspecific δ‐aminolevulinate synthase (ALAS‐N) were examined in murine Friend virus‐transformed erythroleukemia (MEL) cells using nonradioactive in situ hybridization. Following dimethyl sulfoxide (DMSO) treatment, ALAS‐E mRNA increased markedly, while ALAS‐N mRNA did not increase in wild‐type MEL cells. In contrast, in a DMSO‐resistant clone of MEL cells, ALAS‐E was not detectable before and after DMSO treatment. These findings suggest that ALAS‐E and ALAS‐N mRNAs are under separate controls and that the expression of ALAS‐E mRNA is a critical event

ISSN:0361-8609    

DOI:10.1002/ajh.2830390114

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1992

数据来源: WILEY

摘要:

AbstractDNA‐synthesis state of circulating burst forming unit‐erythroid (BFU‐E) was evaluated in patients with sickle cell anemia and correlated with percent of fetal hemoglobin synthesized in the BFU‐E‐derived cells. Percentage of S‐phase BFU‐E inversely correlated with percent fetal hemoglobin synthesized in the BFU‐E‐derived cells (simple linear correlation coefficient, r = −0.8,P= 0.0302; polynomial regression, R = ‐0.99,P= 0.0002). This observation is of relevance to our understanding of the relationship between the developmental stage of the erythroid progenitors and expre

ISSN:0361-8609    

DOI:10.1002/ajh.2830390115

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1992

数据来源: WILEY

ISSN:0361-8609    

DOI:10.1002/ajh.2830390116

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1992

数据来源: WILEY

ISSN:0361-8609    

DOI:10.1002/ajh.2830390117

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1992

数据来源: WILEY

ISSN:0361-8609    

DOI:10.1002/ajh.2830390118

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1992

数据来源: WILEY

ISSN:0361-8609    

DOI:10.1002/ajh.2830390119

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1992

数据来源: WILEY

ISSN:0361-8609    

DOI:10.1002/ajh.2830390120

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1992

数据来源: WILEY

ISSN:0361-8609    

DOI:10.1002/ajh.2830390121

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1992

数据来源: WILEY