摘要:

AbstractBlood and bone marrow samples from 20 individuals with reactive conditions and 26 cases of acute and chronic myeloid leukemias were tested for the presence of lysozyme, alpha‐1‐antitrypsin (α‐1‐AT), and alpha‐1‐antichymotrypsin (α‐1‐ACT). We compared the reactivity of samples in smears, cytocentrifuge preparations, and paraffin sections.Lysozyme, alpha‐1‐antitrypsin, and alpha‐1‐antichymotrypsin were found only in polymorphonuclear leukocytes and monocytes and their precursors. Lymphocytes, Erosetting cells, Con A‐activated lymphocytes, natural killer (NK) cells, red blood cells, erythroblasts, and megakaryocytes were consistently negative.Leukemic myeloblasts showed definite reactivity for both alpha‐1‐antitrypsin and α‐1‐ACT, but not for lysozyme. By contrast, lysozyme was present in poorly differentiated leukemic monoblasts, while alpha‐1‐antitrypsin and alpha‐1‐antichymotrypsin showed only weak reactivity. More mature myeloid and moncytic cells showed positive staining for all three antigens tested with differences in staining distribution and intensity.In four cases of chronic myeloid leukemia (CML), circulating mature polymorphonuclear leukocytes were deficient in both lysozymne and alpha‐1‐antitrypsin.The use of lysozyme, alpha‐1‐antitrypsin, and alpha‐1‐antichymotrypsin identifies normal and leukemic cells of the myeloid‐monocytic series at all stages of matura

ISSN:0361-8609    

DOI:10.1002/ajh.2830210112

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1986

数据来源: WILEY

摘要:

AbstractSuccessful cadaveric renal transplantation was accomplished in a patient with Epstein syndrome, a triad of macrothrombocytopenia, partial high‐frequency hearing loss, and nephritis, which often progresses to complete renal failure. The success of the transplant demonstrates that the macrothrombocytopenia which occurs in this syndrome is not a contraindication to aggressive management of end‐stage renal dise

ISSN:0361-8609    

DOI:10.1002/ajh.2830210113

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1986

数据来源: WILEY

ISSN:0361-8609    

DOI:10.1002/ajh.2830210114

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1986

数据来源: WILEY

ISSN:0361-8609    

DOI:10.1002/ajh.2830210115

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1986

数据来源: WILEY

ISSN:0361-8609    

DOI:10.1002/ajh.2830210101

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1986

数据来源: WILEY