|
1. |
Myelodysplastic syndromes and malignant solid tumors: Analysis of 21 cases |
|
American Journal of Hematology,
Volume 41,
Issue 1,
1992,
Page 1-4
Jordi Sans‐Sabrafen,
Josep Buxó‐Costa,
Soledad Woessner,
Lourdes Florensa,
Carles Besses,
NÚRia Malats,
Miquel Porta,
Preview
|
PDF (419KB)
|
|
摘要:
AbstractWe studied the association between myelodysplastic syndromes (MDS) and malignancies in a cohort of 155 patients with MDS, 21 of whom presented malignant solid tumors. Myelodysplasia was present after the diagnosis of cancer in eight patients (interval between the diagnosis of both conditions 18 months, median survival 49.5 months), simultaneously with diagnosis in 11 (median survival 8 months), and before malignancy in two patients (interval between the diagnosis of both conditions 47 and 7 months). One patient was given chemotherapy for lung cancer, and three patients received radiotherapy for adenocarcinoma of the kidney and cancer of the prostate. At the time of diagnosis of MDS, nine patients already presented metastatic spread. Fourteen patients died, ten as a result of tumor‐related complications and four because of transformation to acute nonlymphocytic leukemia. The analysis of the incidence of malignancy in patients with MDS was statistically significant for males, and the relative risk was significant in both sexes. The results of this study show that MDS patients present a higher incidence of malignant tumors than the general population, that MDS may be of real paraneoplastic significance, and that the occurrence of MDS in cancer patients may be considered to be related to the malignancy rather than an independent phenomenon. © 1992 Wiley‐Liss,
ISSN:0361-8609
DOI:10.1002/ajh.2830410102
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1992
数据来源: WILEY
|
2. |
Cyclosporine and prednisone therapy for pure red cell aplasia in patients with chronic lymphocytic leukemia |
|
American Journal of Hematology,
Volume 41,
Issue 1,
1992,
Page 5-12
G. Chikkappa,
D. Pasquale,
M. H. Zarrabi,
R. J. Weiler,
M. Divakara,
M. F. Tsan,
Preview
|
PDF (750KB)
|
|
摘要:
AbstractWe describe the characteristics of response to treatment with cyclosporine (CYA) plus prednisone in seven episodes of pure red cell aplasia (PRCA) in four patients with B cell chronic lymphocytic leukemia (CLL). Fourteen episodes of PRCA occurred in four patients with CLL. Eleven episodes were treated with conventional therapies which included an alkylating agent and prednisone. Four episodes that failed to respond to conventional therapies and an additional three episodes were treated with CYA and prednisone. Six of the seven episodes, including three of four which had failed conventional therapies, responded to CYA plus prednisone compared with six of eleven episodes treated with conventional therapies. Response to CYA and prednisone occurred without a reduction in leukemic mass. In contrast, PRCA remission did not occur until after leukemic mass reduction in three of four patients treated successfully with conventional therapies. Time to response was shorter (14 ± 3 days) with CYA plus prednisone than with conventional therapies (154 ± 97 days) in three of four patients. These results indicate that CYA plus prednisone is an effective therapy for the induction of remission from PRCA in patients with CLL. © 1992 Wiley‐Liss,
ISSN:0361-8609
DOI:10.1002/ajh.2830410103
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1992
数据来源: WILEY
|
3. |
Splenectomy vs. alpha interferon: A randomized study in patients with previously untreated hairy cell leukemia |
|
American Journal of Hematology,
Volume 41,
Issue 1,
1992,
Page 13-18
Richard V. Smalley,
Susan Anderson,
Joseph Connors,
Richard L. Tuttle,
John K. Whisnant,
William Robinson,
Preview
|
PDF (595KB)
|
|
摘要:
AbstractTwenty patients with previously untreated hairy cell leukemia were randomized to undergo either splenectomy or to receive interferon alfa‐N1, a highly purified natural alpha interferon, as primary therapy. A response in the peripheral blood elements to a hemoglobin greater than 110 gm/l, a granulocyte count greater than 1 × 109/l, and a platelet count greater than 100 × 109/l (Catovsky criteria) was noted in all ten patients receiving alpha interferon but in only three of the patients undergoing splenectomy (P=18 months) than in the splenectomy patients (<1 month). Survival was no different since patients relapsing following splenectomy subsequently responded to alpha interferon. A significant decrease in leukemic bone marrow infiltration was observed in seven of ten patients receiving alpha interferon and in none of the patients undergoing splenectomy. Side effects, primarily infections, were more frequent in patients receiving interferon. Alpha interferon is preferable to splenectomy as initial treatment for hairy cell leukemia. © 1992 Wiley‐Lis
ISSN:0361-8609
DOI:10.1002/ajh.2830410104
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1992
数据来源: WILEY
|
4. |
Epidemiology of AIDS in females with hemophilia and other chronic bleeding disorders in the united states: Comparisons with males with chronic bleeding disorders and AIDS and with nonhemophilic female blood‐transfusion recipients with AIDS |
|
American Journal of Hematology,
Volume 41,
Issue 1,
1992,
Page 19-23
Robert C. Holman,
Matthew J. Clarke,
Bruce L. Evatt,
Terence L. Chorba,
Preview
|
PDF (450KB)
|
|
摘要:
AbstractFrom January 1, 1981 through June 30, 1990, 32 females with chronic bleeding disorders were diagnosed with acquired immunodeficiency syndrome (AIDS) in the United States. Most (81.3%) were white and ≧30 years of age, with a median age of 37.5 years. Eighteen (56.3%) had von Willebrand's disease.Pneumocystis cariniipneumonia was reported for 16 (50%). None had Kaposi sarcoma. The median survival time was 10.8 months, with a cumulative probability of survival at 1 year of 47.3% and at 2 years of 27.6%. We compared the demographic data and survival times of these females with those of males with a chronic bleeding disorder and AIDS, and with those of nonhemophilic females with AIDS whose exposure to the human immunodeficiency virus (HIV) was through receipt of blood transfusions, blood components, or tissue. The principal demographic difference was age distribution. The females with chronic bleeding disorders tended to be younger than the transfused, nonhemophilic females, but older than the males. The survival time from AIDS diagnosis to death for the females with chronic bleeding disorders did not differ statistically from that of the other two groups, although older nonhemophilic females whose exposure was transfusion may progress more rapidly to AIDS. © 1992 Wiley‐Liss,
ISSN:0361-8609
DOI:10.1002/ajh.2830410105
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1992
数据来源: WILEY
|
5. |
Protein C survival during replacement therapy in homozygous protein C deficiency |
|
American Journal of Hematology,
Volume 41,
Issue 1,
1992,
Page 24-31
Richard A. Marlar,
Robert R. Montgomery,
Renee M. Madden,
Richard H. Sills,
Paula K. Groncy,
Preview
|
PDF (750KB)
|
|
摘要:
AbstractHomozygous protein C (PC) deficiency is a rare genetic defect that usually results in fatal thrombotic complications (purpura fulminans and DIC), but it can be successfully managed with oral anticoagulants or PC replacement. The successful use of PC replacement for two individuals is described. The activity and antigen levels of PC in fresh frozen plasma (FFP) and prothrombin complex concentrate (PCC) are also reported. The concentration of PC in FFP is 87 ± 15 units/dl. PC is present in all PCC analyzed; however, a ten‐fold difference between the various brands and/or lots is noted. The PC activity and antigen correlates well with no significant levels of APC. Upon infusion of FFP into two homozygous PC‐deficient children, the PC levels obtained were ≦30 units/dl post‐ infusion and undetectable after 12‐18 hr. With infusions of PCC, plasma levels of PC obtained were 100‐145 units/dl and<10 units/dl after 48 hr. The percent recovery and half‐lives of PC from FFP and PCC were 49.8% and 7.8 hr, and 84% and 7.4 hr, respectively. One infant was treated every 48 hr for 2 years without significant purpura fulminans or DIC complications. The levels of the other PC system components did not change during the infusion of the PC‐rich material. Based on this information, a specific replacement protocol has been developed using a PC‐rich concentrate. However, several problems may arise with the „less pure”︁ PC‐rich concentrates: catheter‐tip thrombosis, related large vessel thrombosis and blood‐transmitted diseases. With a specific PC concentrate, replacement therapy is a viable alternative for the long‐term management/treatment of homozygous PC de
ISSN:0361-8609
DOI:10.1002/ajh.2830410106
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1992
数据来源: WILEY
|
6. |
Circulating thrombomodulin as a novel endothelial cell marker: Comparison of its behavior with von willebrand factor and tissue‐type plasminogen activator |
|
American Journal of Hematology,
Volume 41,
Issue 1,
1992,
Page 32-39
Hoyu Takahashi,
Seiki Ito,
Masaharu Hanano,
Ken Wada,
Hiroe Niwano,
Yoshinobu Seki,
Akira Shibata,
Preview
|
PDF (748KB)
|
|
摘要:
AbstractCirculating thrombomodulin is a novel endothelial cell marker, which may reflect the endothelial injury. Plasma levels of thrombomodulin were quantitated by an enzymelinked immunosorbent assay (ELISA) in patients with hematological malignancies, liver disease, diabetes mellitus, collagen disease, thrombotic disease, and disseminated intravascular coagulation (DIC), and the thrombomodulin values were compared with those of von Willebrand factor antigen (vWf:Ag) and tissue‐type plasminogen activator (t‐PA) which are released from stimulated or damaged endothelial cells. The mean plasma concentrations of thrombomodulin in these disease states were elevated as compared with healthy subjects. A relatively high mean thrombomodulin level was observed in DIC, liver disease, and collagen disease. Abnormally high thrombomodulin values (>normal mean value + 3 SD) were found in 32.3% of patients with hematological malignancies, 57.7% of patients with liver disease, 39.3% of patients with diabetes mellitus, 30.0% of patients with collagen disease, 23.1% of patients with thrombotic disease, and 69.0% of patients with DIC. Plasma concentrations of both vWf:Ag and t‐PA were also elevated in these patients. On the whole, the plasma thrombomodulin concentration was positively correlated with vWf:Ag (r = 0.441, P<0.001) and t‐PA (r = 0.398, P<0.001). These findings indicate that the elevation of plasma thrombomodulin is frequently seen in a variety of diseases and circulating thrombomodulin is possibly useful for evaluating the endothelial damage in selected disease states. © 1992 Wiley
ISSN:0361-8609
DOI:10.1002/ajh.2830410107
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1992
数据来源: WILEY
|
7. |
Allogeneic bone marrow transplantation for hematological malignancies following etoposide, cyclophosphamide, and fractionated total body irradiation |
|
American Journal of Hematology,
Volume 41,
Issue 1,
1992,
Page 40-44
Jonathan C. Yau,
Susan D. Huan,
Charles F. Lemaistre,
Carole M. Meneghetti,
Borje S. Andersson,
Ralph O. Wallerstein,
Shiao Y. Woo,
Lane J. Brunner,
Meletios A. Dimopoulos,
Sundar Jagannath,
Albert B. Deisseroth,
Gary Spitzer,
Verneeda Spencer,
Jorge A. Spinolo,
Karel A. Dicke,
Sergio Giralt,
Preview
|
PDF (474KB)
|
|
摘要:
AbstractForty‐three patients received etoposide, cyclophosphamide, and fractionated total body irradiation before allogeneic marrow transplantation. Fifteen patients had chronic myelogenous leukemia in chronic phase or acute leukemia in first remission (standard risk) and twenty‐eight patients with more advanced disease (high risk). All patients received etoposide 1,500 mg/m2intravenously on day –8, cyclophosphamide 60 mg/kg/day intravenously on days –7 and –6, and total body irradiation at 170 cGy twice a day on days –3, –2, and –1. During the first 100 days 12 high risk patients (43%) died from causes unrelated to relapse while none of the standard risk patients died. Renal and hepatic dysfunction were also significantly increased during the first 14 days in the high risk group. The addition of 1,500 mg/m2of etoposide to the cyclophosphamide and total body irradiation was well tolerated for patients with standard risk. However, the regimen was poorly tolerated with high mortality in patients with more advanced disease. © 1992
ISSN:0361-8609
DOI:10.1002/ajh.2830410108
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1992
数据来源: WILEY
|
8. |
Recombinant interferon‐α2A as maintenance treatment for patients with advanced stage chronic lymphocytic leukemia responding to chemotherapy |
|
American Journal of Hematology,
Volume 41,
Issue 1,
1992,
Page 45-49
Felicetto Ferrara,
Vincenzo Rametta,
Giuseppina Mele,
Iolanda Antinolfi,
Vincenzo Mettivier,
Renato Cimino,
Preview
|
PDF (387KB)
|
|
摘要:
AbstractForty‐five patients suffering from advanced B‐CLL were randomized to receive interferon‐α (IFNα) or no treatment after achieving complete remission or partial response, following a chemotherapy protocol called MINa. The two groups were fully comparable in terms of clinical characteristics and level of response obtained by chemotherapy. IFNα was given at a dose of 3 megaunits three times a week intramuscularly for 1 year. The IFN‐treated patient group showed a significantly longer duration of response and a less frequent incidence of infections as compared to the no treatment group. A minority of patients who had had partial response to chemotherapy obtained complete remission while on therapy with IFNα. Toxicity was mild and patient compliance was excellent. We conclude that IFNα may have a role as maintenance therapy in CLL for patients responding to chemotherapy. © 1992 Wi
ISSN:0361-8609
DOI:10.1002/ajh.2830410109
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1992
数据来源: WILEY
|
9. |
Elevated neutrophil function in chronic neutrophilic leukemia |
|
American Journal of Hematology,
Volume 41,
Issue 1,
1992,
Page 50-56
Tetsuya Ohtsuki,
Hiroaki Mizukami,
Fumihiko Kimura,
Mayumi Ohnishi,
Naokazu Nagata,
Kazuo Motoyoshi,
Yoshiya Katsura,
Yoshifusa Matsu‐ura,
Preview
|
PDF (663KB)
|
|
摘要:
AbstractA 65‐year‐old man with marked leukocytosis was admitted for diagnosis and treatment. His peripheral blood leukocyte count was 37,500/μI and the leukocytes consisted of mature neutrophil‐like cells. A high neutrophil alkaline phosphatase score and a normal bone marrow cell karyotype suggested that the patient had chronic neutrophilic leukemia rather than chronic myeloid leukemia. Several neutrophil functions, such as superoxide production, nitroblue tetrazolium reduction activity, and phagocytosis, were elevated. These data and the morphological features (toxic granules and Döhle bodies) indicated that the patient's neutrophils were in an activated stage. © 1992 Wiley
ISSN:0361-8609
DOI:10.1002/ajh.2830410110
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1992
数据来源: WILEY
|
10. |
Coexistence of congenital afibrinogenemia and protein c deficiency in a patient |
|
American Journal of Hematology,
Volume 41,
Issue 1,
1992,
Page 57-60
Masaharu Hanano,
Hoyu Takahashi,
Akira Shibata,
Masakazu Itoh,
Preview
|
PDF (302KB)
|
|
摘要:
AbstractA rare association of congenital afibrinogenemia and hereditary protein C deficiency is described in a 37‐year‐old female who suffered from ischemic necrosis in the left first toe. The diagnosis of afibrinogenemia was assessed by the absence of fibrinogen in clotting and immunological assays. The diagnosis of hereditary heterozygous type I protein C deficiency was based on the evidence of proportional decreases of activity and antigen of plasma protein C in the propositus, her mother, and two maternal aunts. © 1992 Wiley‐Lis
ISSN:0361-8609
DOI:10.1002/ajh.2830410111
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1992
数据来源: WILEY
|
|