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| 1. |
Acute myelogenous leukemia subsequent to therapy for a different neoplasm: Clinical features and response to therapy |
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American Journal of Hematology,
Volume 3,
Issue 3,
1977,
Page 209-218
Harvey D. Preisler,
Gary H. Lyman,
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摘要:
AbstractThe clinical characteristics of 10 patients with acute myelogenous leukemia (AML) which developed subsequently to treatment for another neoplasm are described. This disease appears to differ from “spontaneous” AML in being associated with lesser degrees of leukemic infiltration of the marrow and more frequent chromosomal aberrations. Only one of the nine patients who received chemotherapy attained remission status, and the mean and median survivals from the initiation of chemotherapy were 2.7 months and one month respectively. Nine of the 10 patients died as a result of infection. The refractoriness of this form of AML to chemotherapy was borne out by a review of the literature, which revealed only two remissions in 32 treated patients. The implications for the management of this disease are discus
ISSN:0361-8609
DOI:10.1002/ajh.2830030301
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1977
数据来源: WILEY
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| 2. |
Penicillin‐induced immunohemolytic anemia associated with circulating immune complexes |
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American Journal of Hematology,
Volume 3,
Issue 3,
1977,
Page 219-223
T. Funicella,
R. S. Weinger,
J. L. Moake,
M. Spruell,
R. D. Rossen,
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PDF (289KB)
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摘要:
AbstractEleven days after administration of multiple penicillin analogs, a 55‐year‐old female developed a Coombs‐positive hemolytic anemia. The patient's erythrocytes were coated with IgG, complement components (C4/C3) and her serum contained elevated125I‐Clq binding activity (a measure of the presence of immune complexes). Her serum, in the presence of fresh complement and penicillin, induced complement sensitization of normal erythrocytes. Immune complex‐mediated complement activation and the haptene type of erythrocyte sensitization accounted for accelerated red blood cell destruction in thi
ISSN:0361-8609
DOI:10.1002/ajh.2830030302
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1977
数据来源: WILEY
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| 3. |
Coagulopathy in amyloidosis: Combined deficiency of factors IX and X |
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American Journal of Hematology,
Volume 3,
Issue 3,
1977,
Page 225-235
Richard A. McPherson,
John W. Onstad,
Richard J. Ugoretz,
Paul L. Wolf,
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PDF (975KB)
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摘要:
AbstractCombined severe deficiencies of blood clotting factors IX and X were observed in 2 patients who suffered from systemic amyloidosis. This unique deficiency state was marked by refractoriness to Vitamin K as well as to transfusion therapy. Increased antithrombin activity was present in both individuals and corresponded in time to the emergence of a monoclonal IgG kappa light chain paraprotein in 1. Both patients demonstrated profound bleeding disorders. It is hypothesized that the Vitamin K dependent factors have special affinity for amyloid deposits due to an unusual amino acid (γ‐carboxyglutamic acid) present in these facto
ISSN:0361-8609
DOI:10.1002/ajh.2830030303
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1977
数据来源: WILEY
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