ISSN:0167-7063    

DOI:10.3109/01677069509083457

出版商:Taylor&Francis    

年代:1995

数据来源: Taylor

摘要:

We have identified a new gene inDrosophilaon the basis of a mutation that affects both behavior and neuronal excitability. This mutation, calledbemused (bem)is the result of a P element insertion at cytological position 85D. Flies defective atbemdisplay greatly reduced coordination, flight ability and fertility. Thebemmutation also affects synaptic transmission at the larval neuromuscular junction. In particular,bemlarvae display a more rapid onset of augmentation thanbem+larvae. This effect is potentiated by the potassium channel blocking drug quinidine. The increased transmitter release that occurs inbemmutants following repetitive nerve stimulation is accompanied by the appearance of extra action potentials in the motor neuron. We conclude that thebemmutation increases neuronal excitability, possibly as a result of a defect in an ion channel structural or regulatory gene.

ISSN:0167-7063    

DOI:10.3109/01677069509083458

出版商:Taylor&Francis    

年代:1995

数据来源: Taylor

摘要:

InDrosophila melanogaster, during the mid third instar of development larvae cease foraging and commence a period of increased locomotor activity referred to as wandering behavior. In this study, we quantified the wild type larval response to light during the foraging (first, second, and early third instars) and wandering (late third instar) stages of development. Foraging larvae in the first, second and early third instars exhibited a robust and marked aversion to light (negative phototaxis). From the mid larval third instar larvae showed a decrease in photonegative behavior, until just before pupation when the response of wandering larvae to light became random. The photobehavior of several strains known to affect the adult visual system were also studied. All but four exhibited normal phototaxis in the foraging and wandering stages,glmutant larvae failed to respond to light during the foraging stage likely due to lack of larval photoreceptors. Larvae carrying three different mutations in the rhodopsin RH1 gene continued to express negative phototaxis throughout both the foraging and wandering stages. These results suggest that the transition from negative phototaxis toward photoneutral behavior characteristic of the wandering third instar larva requires vision.

ISSN:0167-7063    

DOI:10.3109/01677069509083459

出版商:Taylor&Francis    

年代:1995

数据来源: Taylor