摘要:

To investigate the motor rhythm of the Syrian hamster under natural photoperiod and to relate these findings to pineal rhythm, animals were left undisturbed in metabolic cages in which stabilimeter systems registered motor activity, photovoltaic cells registered light intensity, and in which urinary output was used for the assay of the major melatonin metabolite 6‐sulphatoxymelatonin. The motor activity of two animals was monitored during 1 month and showed a striking similarity. Melatonin secretion was measured during 3 consecutive days and showed a night/day ratio in both animals that was relatively constant and that was coupled to the diurnal rhythm of the animals' activit

ISSN:0742-3098    

DOI:10.1111/j.1600-079X.1987.tb00845.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

5‐hydroxytryptophol (5HTL) occurs in the pineal gland of the rat at levels comparable to those of melatonin, yet few studies have been conducted to investigate 5HTL as a potential alternative pineal hormone. In this study the pineals of 90‐day‐old male Sprague Dawley rats have been assayed by high performance liquid chromatography coupled with electrochemical detection. Significant (P<.0001) circadian variation was measured in 5HTL levels, and a fivefold plateau elevation occured during the middle of the light period. By comparison with the timing of the variations in N‐acetyl serotonin and melatonin levels, it is suggested that 5HTL may not be regulated by simple competition with N‐acetyl transferase for the common substrate 5HT but may, in fact, be regulated independently. Literature supporting such a suggestion, and a model incorporating it, are presented for d

ISSN:0742-3098    

DOI:10.1111/j.1600-079X.1987.tb00846.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

ISSN:0742-3098    

DOI:10.1111/j.1600-079X.1987.tb00847.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

ISSN:0742-3098    

DOI:10.1111/j.1600-079X.1987.tb00848.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY