摘要:

Investigations using animal models show that estrogen is related to enzyme release, specifically creatine kinase, from exercised skeletal muscle. In humans, women have lower resting blood creatine kinase levels than men and have an attenuated blood creatine kinase response after prolonged endurance exercise. These results have led to the common belief that women may be protected from exercise-induced muscle damage due to circulating estrogen. Studies using laboratory models to examine gender differences in exercise-induced muscle damage, however, have not consistently documented that women have an attenuated response compared with men. Furthermore, research on exercise responses in women with different circulating levels of estrogen has not found estrogen to be related to indicators of muscle damage. Recent studies, in fact, have reported that women may experience more muscle damage, based on indirect measures, than men. Although some data exist that women may have a faster recovery from exercise-induced muscle damage, these results are tentative at this time.

ISSN:1363-1950    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

Women differ from men in thermal responses to exogenous heat load and heat loss as well as to endogenous heat load during exercise, because they usually have a larger ratio of body surface to body mass, a greater subcutaneous fat content, and lower exercise capacity. When these differences are eliminated in experimental studies, it appears that women's sweating response to heat load is still smaller than that of men, but they are able to maintain their core body temperature on a similar level to that of men as a result of greater evaporative efficiency of sweating. In addition, the changing rate of sex hormone release during the menstrual cycle modifies thermoregulation in women, so there are differences in resting body temperature and thermal responses to positive or negative heat loads depending on the phase of the cycle. In this review, the changes in thermoregulation in young women taking oral contraceptives and those associated with the menopause and hormonal replacement therapy are also described.

ISSN:1363-1950    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

Food products have variously been reported as causing, perpetuating or treating irritable bowel syndrome. The evidence for this is reviewed with regard to recent studies investigating symptom reporting, mono- and disaccharide malabsorption and probiotics. The development of objective measures remains an urgent priority because of the high placebo response to any dietary intervention in irritable bowel syndrome.

ISSN:1363-1950    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

The present review addresses data from randomized clinical trials on perioperative nutrition in patients with gastrointestinal cancer. It is important to appreciate that different approaches can be used with regard to timing of administration of nutritional support (preoperative versus postoperative), route of administration (parenteral versus enteral) and composition of the admixtures given (standard versus immune-enriched diets). The rationale underlying these approaches may also vary, and may include correction of nutritional status, attenuation of the acute-phase response through better preservation of gut function, and potentiation of the immune response.

ISSN:1363-1950    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

The gut has often been suggested to be one of the essential factors in the pathogenesis of many nosocomial infections and possibly multi-organ failure. In the light of several recent studies, the importance of normal gut bacterial flora and the role of the gastrointestinal tract in human immune function are now better understood. It now seems clear that stimulation ofgut-associated lymphoid tissue through enteral feeding is the key to the preservation of mucosal-derived immunity; however, the role of this native gastrointestinal immune function in the subsequent development of sepsis and multi-organ dysfunction syndrome remains the subject of ongoing study.

ISSN:1363-1950    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

Allergic disorders of the gastrointestinal tract were once thought of as primarily dermatological manifestations of common food allergens such as peanuts. Recently, greater attention to these products has arisen as complex mechanisms of action have been more clearly delineated. Specific disease states have recently been recognized associated with gastrointestinal reactions to foods, such as celiac disease, infantile formula protein intolerance, and eosinophilic gastroenteritis have been well described. More recently, eosinophilic esophagitis and allergic constipation have been described. This article will review current information regarding the commonly identified gastrointestinal allergic states, and more detailed information regarding two new allergic entities will also be described.

ISSN:1363-1950    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

The present article reviews the current literature on the role of diet and other trophic factors in the treatment of short-bowel syndrome. Results using glutamine, growth hormone and glucagon-like peptide 2 are reviewed. Although experimental animal data would suggest that various growth factors are of benefit in the treatment of short-bowel syndrome, only a few clinical studies have made the same claim.

ISSN:1363-1950    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

Nutritional derangements are frequent in inflammatory bowel disease. In the past year significant work has been published examining the mechanisms of impaired food intake in animal models of inflammatory bowel disease, which allow a better understanding of these processes. Data from the same laboratory have shed further light on the relative role of underfeeding and inflammation on the growth retardation associated with intestinal inflammation. Other studies have provided further data on the risk factors and predictive biomarkers of bone loss in patients with inflammatory bowel disease. The potential role of enteral nutrition as primary therapy for Crohn's disease is particularly addressed in this review. Recent contributions to the field emphasized the special importance of this modality of therapy in paediatric patients. The possible mechanisms for such a therapeutic action are not well understood. Other nutrients may have a therapeutic potential in inflammatory bowel disease. In particular, recent data on the in-vivo anti-inflammatory actions of butyrate merit special mention. Finally, novel nutritional therapeutic strategies for inflammatory bowel disease, such as transforming growth factor-beta2-enriched enteral feeding, or hydrothermally processed cereals have recently been explored.

ISSN:1363-1950    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

Approximately 70% of the immune system is localized in the gastrointestinal tract. The saliva and gastrointestinal secretions, as well as flora (probiotics) and supplied fibres (prebiotics), are important for optimal function. Probiotic bacteria have been shown to influence the immune system through several molecular mechanisms. Pre-, pro- and synbiotics (products produced by fermentation) offer both protection against and cure of a variety of endemic and acute diseases. This review summarizes the present experience in various forms of diarrhoea, inflammatory bowel disease, andHelicobacterinfections, in intensive care patients and in connection with extensive surgery.

ISSN:1363-1950    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

In the past year, some relevant papers related to the diagnosis of malnutrition and its pathogenesis in cirrhosis have been published. The value of anthropometrics in the nutritional assessment of end-stage cirrhotic patients has been reinforced. Also, the role of bioelectrical impedance analysis in these patients has been redefined. Several papers have investigated the relationship between leptin and malnutrition in chronic liver disease, particularly the role of alcoholism in hyperleptinaemia, and the importance of protein-bound leptin in these patients. In other papers, the impact of both undernutrition and obesity on the outcome of liver transplantation has been investigated. Two randomized, controlled trials on enteral nutrition in liver disease have been published in this period. One of them deals with a clinical situation (i.e. severe alcoholic hepatitis) associated with a high mortality rate, whereas the second is the first controlled trial in the field of preoperative nutrition in liver transplantation. Finally, some papers provide further arguments in the dilemma of which route of nutrition (enteral or parenteral) is better in cirrhosis.

ISSN:1363-1950    

出版商:OVID    

年代:2001

数据来源: OVID