摘要:

The majority of the resting energy expenditure can be explained by the energy needs of a few highly metabolic organs, making up a small percentage of the body by weight. The relationship of the specific size, individual metabolism, and proportional contribution to the actual body weight and total energy expenditure for each of these organs is a dynamic process throughout growth and development, the onset of disease, and changes in nutritional status. Defining the energy needs of the individual tissues and organ systems immeasurably enhances our understanding of the body's response to these clinical processes, which otherwise could not easily be evaluated by focusing solely on total energy expenditure, fat-free mass, nitrogen imbalance, or actual body weight. Recently reported studies have served mainly to reinforce concepts described previously, and clarify some areas of controversy.

ISSN:1363-1950    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

The metabolic changes that occur after cardiac surgery result from a complex interaction between the effects of surgery and extracorporeal circulationper se, the inflammatory response to surgical trauma and extracorporeal circulation, perioperative use of hypothermia, the cardiovascular and neuroendocrine responses characteristic to cardiac surgery, and the drugs and blood products used to support circulation during and after operation. These changes include among others increased oxygen consumption and energy expenditure and increased secretion of insulin, growth hormone, adrenocorticotrophic hormone, cortisol, epinephrine and norepinephrine. Other changes include decreased total-Trijodthyronine levels, hyperglycemia, hyperlactatemia, increased glutamate, aspartate and free fatty acid concentrations, hypokalemia, an increased production of inflammatory cytokines and increased consumption of complement and adhesion molecules. There is evidence that better control of metabolic abnormalities improves the patients' outcome.

ISSN:1363-1950    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

In target organs, insulin switches substrate utilization from free fatty acids to glucose, a change that: (i) is oxygen-efficient; (ii) repletes glycogen stores; (iii) removes potentially toxic fatty acids; and (iv) restores intracellular potassium. During or after an ischaemic challenge, the insulin metabolic mode should protect cellular functions provided that insulin can reach the ischaemic tissue. Insulin, however, also exerts non-metabolic effects, such as membrane hyperpolarization, the stimulation of adrenergic activity, and inhibition of parasympathetic tone, which may counter its beneficial metabolic actions. The net balance between the favourable and unfavourable effects of insulin on ischaemic tissues depends on: (i) the dose-response of the various effects; (ii) the presence of insulin resistance; (iii) the coexistence of hyperglycaemia; and (iv) the stage of ischaemic tissue damage. At present, a role for glucose-insulin-potassium infusions in clinical practice seems to be clearly established in the case of diabetic patients with acute coronary syndromes, and in patients undergoing urgent or elective cardiac surgery. Its role as an adjunctive therapy in the management of myocardial infarction in non-diabetic individuals has been tested in several clinical trials; however, the evidence emerging from them is inconclusive.

ISSN:1363-1950    

出版商:OVID    

年代:2001

数据来源: OVID

ISSN:1363-1950    

出版商:OVID    

年代:2001

数据来源: OVID