ISSN:1363-1950    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

Insulin resistance is a central feature of the metabolic response after elective surgery as well as other trauma, and has been shown to be a predictor of the length of stay after surgery. Carbohydrate treatment instead of overnight fasting before surgery has been shown to reduce postoperative insulin resistance and to reduce hospital stay approximately 20% after elective surgery. For potential use as a clinical routine before surgery, a carbohydrate-rich drink was developed. Gastric emptying of a 50 g oral carbohydrate load using this drink is complete within 90 min after intake. Oral carbohydrate loading before surgery has confirmed previous data, using glucose and insulin infusions, that postoperative insulin resistance is reduced compared with overnight fasted patients before surgery, and this is associated with improved well-being before and after surgery.

ISSN:1363-1950    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

Nuclear magnetic resonance spectroscopy provides non-invasive and real-time assessment of the metabolic fluxes in skeletal muscle during exercise, recovery from exercise and stimulation by insulin. Carbon-13 nuclear magnetic resonance spectroscopy has proved that reduced glycogen synthesis is a consistent feature of insulin-resistant type 2 diabetic patients, their offspring, and obesity. Low intracellular glucose and glucose-6-phosphate concentrations indicate that decreased glucose transport is mainly responsible for common insulin resistance. An elevation of plasma free fatty acids causes similar alterations of muscle glucose metabolism, and could play a central role in the development of impaired muscle glucose transport associated with insulin resistance.

ISSN:1363-1950    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

Both glutamine and glucose are highly utilized by the small intestine in various animal species. They are, however, very partially oxidized, the major known fate of glucose being lactate and alanine, and that of glutamine being citrulline or proline. At variance with the current view that only the liver and kidney are gluconeogenic organs, because both are the only tissues to express the glucose-6 phosphatase gene, this gene is also expressed in the small intestine in rats and humans, and is strongly induced in insulinopenic states, such as fasting and diabetes. Under the latter conditions, the small intestine contributes 20-25% of whole-body endogenous glucose production. The main small intestine gluconeogenic substrate is glutamine and, to a lesser extent, glycerol. Accounting for these fluxes, the phosphoenolpyruvate carboxykinase gene is strongly induced in insulinopenia and, although up to now it had been considered absent from this tissue, the glycerokinase gene is expressed in the small intestine. The production of glucose by the small intestine may be acutely blunted upon insulin infusion. These new data also emphasize the central role of alanine aminotransferase in the coupling of glutamine and glucose metabolisms in the small intestine.

ISSN:1363-1950    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

The liver plays a central role in the control of glucose production. It is also involved in the regulation of insulin secretion and sensitivity through neural pathways. This review will address recent developments in the mechanisms by which hepatic metabolism affects glucose homeostasis in health and disease. Oral glucose feeding elicits several systemic and hepatic alterations of intermediary metabolism through the activation of neural pathways. How this may affect glucose metabolism will be briefly discussed, and alterations of glucose homeostasis in liver disease will be briefly described. There is evidence that a portion of intrahepatic glucose can be converted into lipids in the process of de-novo lipogenesis. How this may be involved in the control of glycaemia and lipid concentrations will be reviewed. Finally, molecular mechanisms by which the alteration of liver metabolism may affect systemic glucose homeostasis will be outlined.

ISSN:1363-1950    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

Recently, evaluation of organ-specific glucose release showed that renal glucose release is of the same order of magnitude as splanchnic glucose release during the postabsorptive period. Moreover, renal glucose release appeared to be more sensitive to hormone action than did hepatic glucose release, and appeared to have a pre-eminent role during the adaptation to various physiological and pathological conditions. The kidney is now recognized as playing a key role in interorgan glucose metabolism, and particularly in the Cori cycle and glutamine-glucose cycle. During chronic renal failure the suppression of renal glucose release, together with impaired hormone action, decreased glycogen storage and abnormal liver gluconeogenesis, are responsible for an increased risk for hypoglycaemia.

ISSN:1363-1950    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

The lactic acidosis hypothesis of cerebral ischemia has relied on a single finding to support its main postulate: pre-ischemic hyperglycemia-aggravated ischemic brain damage. Although this finding is by no means the proof that the lactic acidosis hypothesis desperately needs, the premise of the hypothesis has been employed in hospitals around the world. A better understanding of some of the processes involved in elevating blood glucose levels pre-ischemia and their influence on the ischemic brain is now available. This understanding offers a unique opportunity to re-examine old dogmas and propose new ideas, in the form of an alternative hypothesis to explain ‘the glucose paradox of cerebral ischemia’.

ISSN:1363-1950    

出版商:OVID    

年代:2001

数据来源: OVID

ISSN:1363-1950    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

Because of the metabolic changes caused by ageing, malnutrition is accompanied by a preferential loss of fat-free mass in the elderly, and it exaggerates the physiological loss of body cell mass, muscle mass and muscle function observed in the aged. Exercise training has positive anabolic effects even in the frail elderly, and may improve the effect of re-nutrition in malnourished elderly patients.

ISSN:1363-1950    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

Food intake and eating patterns, body functions and composition are significantly altered by short-duration space flight. Prolonged missions lasting weeks or months further aggravate these changes, and are responsible for acute or chronic physical impairments at return to ground conditions. Current projects of missions to Mars, resulting in 2 years of microgravity conditions, stress the critical need for the development of optimal nutritional programs and physical countermeasures to prevent body mass and function alterations. This review outlines ground models of microgravity simulation, summarizes the major effects of weightlessness on body composition, protein metabolism, hormonal pattern, and muscle function, and addresses contradictory findings related to the oxidative stress secondary to space flight. Potential countermeasures, such as nutrient intake and physical conditioning, as well as areas of interest for future research both in ground and space medicine, are discussed.

ISSN:1363-1950    

出版商:OVID    

年代:2001

数据来源: OVID