1. |
Editorial |
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Food Additives & Contaminants,
Volume 1,
Issue 2,
1984,
Page 72-72
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PDF (59KB)
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ISSN:0265-203X
DOI:10.1080/02652038409385827
出版商:Taylor & Francis Group
年代:1984
数据来源: Taylor
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2. |
Mechanisms of chemical carcinogenesis: Recent advances |
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Food Additives & Contaminants,
Volume 1,
Issue 2,
1984,
Page 73-80
P. E. Fournier,
G. Thomas,
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PDF (522KB)
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摘要:
The carcinogenetic risk assessment of veterinary drugs has to be envisaged as part of food toxicology. The authors review the recent discoveries which have proved significant for the toxicologist.
ISSN:0265-203X
DOI:10.1080/02652038409385828
出版商:Taylor & Francis Group
年代:1984
数据来源: Taylor
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3. |
Survey of animal drugs with carcinogenic properties† |
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Food Additives & Contaminants,
Volume 1,
Issue 2,
1984,
Page 81-87
Arpad Somogyi,
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PDF (478KB)
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摘要:
Residues of animal drugs with carcinogenic potential cannot always be avoided in food. The risk/benefit evaluation of carcinogenic drugs used in food‐producing animals is a scientifically unresolved problem. Nonetheless, a pragmatic solution taking into account such drugs’ putative mechanisms of action, their relative potency, and their significance in the prevention and therapy of disease must and can be achieved.
ISSN:0265-203X
DOI:10.1080/02652038409385829
出版商:Taylor & Francis Group
年代:1984
数据来源: Taylor
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4. |
The principle of a threshold dose in chemical carcinogenesis |
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Food Additives & Contaminants,
Volume 1,
Issue 2,
1984,
Page 89-94
C. Frayssinet,
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PDF (430KB)
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摘要:
The nature of at least three stages in carcinogenesis by chemical agents justifies the existence of a threshold dose: (1) a cytoplasmic stage during which most carcinogenic molecules are eliminated, (2) a nuclear stage during which certain DNAlesionsare repaired and therefore cannot help to bring about mutations, and (3) an extracellular stage during which mutations are controlled for a long time by positive or negative epigenetic factors.
ISSN:0265-203X
DOI:10.1080/02652038409385830
出版商:Taylor & Francis Group
年代:1984
数据来源: Taylor
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5. |
Potentialité cancérogène des oestrogènes utilisés en élevage |
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Food Additives & Contaminants,
Volume 1,
Issue 2,
1984,
Page 95-100
A. G. Rico,
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PDF (344KB)
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摘要:
The oestrogens that are used in husbandry are oestradiol (natural compound), zeranol (non‐steroid drug) and stilbenes such as diethylstilboestrol (D.E.S.).
ISSN:0265-203X
DOI:10.1080/02652038409385831
出版商:Taylor & Francis Group
年代:1984
数据来源: Taylor
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6. |
Critical analysis of long‐term tests for carcinogenicity |
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Food Additives & Contaminants,
Volume 1,
Issue 2,
1984,
Page 101-107
J. R. P. Cabral,
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摘要:
The objective of long‐term carcinogenicity studies is to observe test animals for a major portion of their lifespan for the development of neoplastic lesions during or after exposure to various doses of a test substance given by an appropriate route. Studies of this type require careful planning and documentation of the experimental design, a high standard of pathology, good animal care and suitable statistical analysis. These requirements are well known and have not undergone major changes during recent years. Rather than giving details of these requirements, which can now be found in many publications, this paper attempts to indicate some of the problems involved in a long‐term carcinogenicity study.
ISSN:0265-203X
DOI:10.1080/02652038409385832
出版商:Taylor & Francis Group
年代:1984
数据来源: Taylor
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7. |
Determination of a virtually non‐carcinogenic dose |
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Food Additives & Contaminants,
Volume 1,
Issue 2,
1984,
Page 109-120
R. Lowy,
P. Manchon,
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PDF (672KB)
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摘要:
The various mathematical models of the dose‐response relationship are briefly reviewed and it is concluded that the Weibull and gamma‐multihit models are at present the best ones. They permit the computation of a ‘virtually safe dose’, for which the carcinogenic risk to man is reasonably negligible, but because of the unknown mechanism of the background response, the models should be used in a mixed form. A modified Crouch and Wilson approach is proposed to evaluate the risk from an actual environmental dose. This takes into account the various uncertainties in risk computations, and results in the application of a safety factor when extrapolating from animals to man.
ISSN:0265-203X
DOI:10.1080/02652038409385833
出版商:Taylor & Francis Group
年代:1984
数据来源: Taylor
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8. |
Bioactivation and bound residues |
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Food Additives & Contaminants,
Volume 1,
Issue 2,
1984,
Page 121-129
V. Burgat‐Sacaze,
A. Rico,
P. Delatour,
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PDF (426KB)
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摘要:
Most toxic Chemicals undergo bioactivation before they can exert their noxious effects. These biotransformations produce very reactive intermediate metabolites which covalently bind to vital cellular components and can lead to a specific toxicity.
ISSN:0265-203X
DOI:10.1080/02652038409385834
出版商:Taylor & Francis Group
年代:1984
数据来源: Taylor
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9. |
Experimentalin vitroapproach to the study of covalent associations |
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Food Additives & Contaminants,
Volume 1,
Issue 2,
1984,
Page 131-146
C. Pantarotto,
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PDF (782KB)
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ISSN:0265-203X
DOI:10.1080/02652038409385835
出版商:Taylor & Francis Group
年代:1984
数据来源: Taylor
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10. |
Determination of the binding of trenbolone and zeranol to rat‐liver DNAin vivoas compared to 17ß‐oestradiol and testosterone |
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Food Additives & Contaminants,
Volume 1,
Issue 2,
1984,
Page 147-155
Béatrice Barraud,
Alain Lugnier,
Guy Dirheimer,
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PDF (491KB)
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摘要:
Thein vivointeractions of trenbolone and zeranol with rat‐liver DNA were assayed by determining their covalent‐binding indices (CBI), which correlate well with the hepatocarcinogenic potencies of chemicals. As controls, 17ß‐oestradiol and testosterone were used. Sixteen hours after intraperitoneal injection of the [3H]‐labelled compounds (specific radioactivity ∼50 Ci/mmol) the animals were sacrificed and the DNA was isolated from the livers and deproteinized by several Sevag extractions and proteinase digestion. Contaminating RNA was eliminated by pancreatic RNAase digestion. Finally, the DNA was further purified by chromatography on hydroxylapatite and by centrifugation in a CsCl gradient. Decreased CBI values after each step of purification showed that extensive purification was essential.
ISSN:0265-203X
DOI:10.1080/02652038409385836
出版商:Taylor & Francis Group
年代:1984
数据来源: Taylor
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