摘要:

Harmonization must proceed for setting the objectives and priorities, for the technical understanding and utilization of data and information, and for the application of the information to regulatory strategies. At the moment there is disharmony along these three lines but there exists great advantage and opportunity in the pan‐European situation. There is a wealth of different kinds of data, information tools, models and experience. There is a willingness for open discussion of the sciences, costs and responsibilities. No historical mould inhibits the process. To maximize the opportunities for success, the European Union—government and industry—should collect and use available data for dietary intake assessments then evaluate the utility of the data and models. An independent working group should develop criteria for applications of the data and for development of new data. A secure clearing‐house should be established to facilitate equitable use of private and public databases.

ISSN:0265-203X    

DOI:10.1080/02652039609374431

出版商:Taylor & Francis Group    

年代:1996

数据来源: Taylor

摘要:

Direct measurement of the intake of food additives is a complex, time‐consuming and expensive process. Prioritization of intake surveys is important to focus initial attention on those additives of most concern. Intakes at or below the Acceptable Daily Intake (ADI) are not of concern, by definition, and therefore a high priority should be given to those additives for which simple, but conservative, theoretical estimates of potential intake indicate a probability of exceeding the ADI. Although ADI values for different additives are equivalent, because they are based on No‐Observed‐Adverse‐Effect Levels (NOAELs), the risk associated with intakes above the ADI can only be determined by reference back to the data which are the basis for the ADI estimation. In consequence the nature and severity of toxic effects detected in animal experiments above the NOAEL should be taken into account in the prioritization of intake surveys. A scheme is proposed which incorporates both exposure estimation and toxicology in determining which food additives should be allocated a high priority for inclusion in intake surveys.

ISSN:0265-203X    

DOI:10.1080/02652039609374432

出版商:Taylor & Francis Group    

年代:1996

数据来源: Taylor

ISSN:0265-203X    

DOI:10.1080/02652039609374433

出版商:Taylor & Francis Group    

年代:1996

数据来源: Taylor

ISSN:0265-203X    

DOI:10.1080/02652039609374420

出版商:Taylor & Francis Group    

年代:1996

数据来源: Taylor