摘要:

Levels of various compounds related to monoamines were assessed in 96 patients with a variety of depressive and nondepressive syndromes. The diagnostic categories were composed retrospectively after examination of International Classification of Diseases (ICD) classifications and all available data in medical reports. All patients underwent the 8-hour probenecid test. Administration of probenecid was partly intravenous (1 g) and partly oral (4 g). In all patients, the cerebrospinal fluid (CSF) levels of 5-hydroxy-indoleacetic acid (5-HIAA), homovanillic acid (HVA), and probenecid were estimated, while in about half of the patients tryptophan and tyrosine were determined in CSF and serum. When the group is taken as a whole, significant positive correlations are found between the CSF levels of 5-HIAA, HVA and probenecid, between the CSF levels of tryptophan and tyrosine, and between tyrosine levels in serum and CSF. A negative correlation is found between CSF probenecid and serum tryptophan. The group of patients was divided in several ways into various subgroups. Analysis of covariance of clinical and biochemical data indicates no significant biochemical differences between any of the subgroups. This retrospective study lacks supportive evidence that any of the clinical syndromes, including the depressive syndromes, is characterized by specific deficiencies of monoamine neurotransmission.

ISSN:0254-4962    

DOI:10.1159/000283945

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

The effect of one night’s total sleep deprivation (SD) on the dexamethasone suppression test (DST) was studied in groups of endogenously and nonendogenously depressed patients who were diagnosed according to different research classification systems. The DST was normal ( 5 µg/dl). After SD a large variability of cortisol nonsuppression was found in this group. Clinical response occurred in the majority of these patients but was more favorable in those who had a trend for normalization of DST. Clinical diagnosis as well as DST seem to have a therapy-predictive value for one night’s total SD in patients with affective diso

ISSN:0254-4962    

DOI:10.1159/000283947

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

Vertebro-basilar insufficiency produces a rich spectrum of psychological and neurological symptoms. Where psychological symptoms dominate the picture, the patient may be presented first to a psychiatrist. The phenomenology of vertebro-basilar insufficiency is discussed with special reference to hallucinatory syndromes, memory disturbance, affective disorders, akinetic mutism, ‘unusual reports’, cortical blindness, agitated delirium, the Capgras syndrome and normal pressure hydrocephalus. Finally, the case of a 61-year-old man illustrating a variety of the neurological and psychological features described in this paper is presen

ISSN:0254-4962    

DOI:10.1159/000283948

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

The report deals with a routine documentation system on psychiatric data. It is demonstrated by several examples concerning syndromatology, premorbid personality and therapy evaluation that important scientific questions can be answered only on the basis of the documentation system without additional research efforts.

ISSN:0254-4962    

DOI:10.1159/000283949

出版商:S. Karger AG    

年代:1983

数据来源: Karger

ISSN:0254-4962    

DOI:10.1159/000283950

出版商:S. Karger AG    

年代:1983

数据来源: Karger