ISSN:1354-523X    

DOI:10.1111/j.1601-0825.1996.tb00211.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

OBJECTIVE: To investigate any possible association between oral lichen planus (OLP) and the humoral immune response to Epstein‐Barr virus (EBV). MATERIAL AND METHODS The population consisted of 22 patients with histologically verified OLP and 22 healthy sex‐ and age‐matched controls without any oral mucosal diseases. Specific serum IgG antibodies (Ab) towards EBV early antigen (EA) and nuclear antigen‐I (EBNA) and IgM Ab towards EBV EA were determined by ELISA.RESULTS: The optometric density (OD) IgG anti‐EA Ab levels were significantly higher in OLP patients than in controls and a significantly negative correlation between duration of symptoms from OLP and IgG anti‐EA OD Ab values was demonstrated. IgM anti‐EA and IgG anti‐EBNA OD Ab levels were not significantly different between the two groups.CONCLUSION: The hypothesis of any possible association between EBV and OLP has never been tested but the present results seem to lend support for an aberration in the humoral response to EBV

ISSN:1354-523X    

DOI:10.1111/j.1601-0825.1996.tb00212.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

OBJECTIVE: The aim of this study was to examine the longitudinal association of selected non‐immune antimicrobial host factors (peroxidases, lysozyme and lactoferrin) to the localized juvenile periodontitis (LJP) disease status.MATERIALS AND METHODS: Peroxidases, lysozyme and lactoferrin were quantitated from seven patients with LJP before and after periodontal therapy. Analyses were performed from simultaneously collected samples of peripheral blood polymorphonuclear leukocytes (PMNs), gingival crevicular fluid (GCF from diseased sites) and paraffin‐stimulated whole saliva. Similar assays were done also from seven periodontally healthy controls.RESULTS During untreated phase of LIP myeloperoxid‐ase, lysozyme and lactoferrin concentrations were remarkably elevated in peripheral blood PMNs, also reflected in their high concentrations in GCF. All these values normalised with respect to healthy controls during the periodontal therapy. No similar longitudinal changes were seen in whole saliva but during therapy salivary per‐oxidase concentrations declined below the control values, in accordance with our previous observations in parotid saliva samples of LJP patients.CONCLUSIONS: In LJP the concentrations of lysozyme, lactoferrin and myeloperoxidase are significantly elevated in peripheral blood PMNs, also reflected in GCF. During periodontal therapy these values decline and approach those observed in healthy controls. No similar changes are seen in stimulated whole

ISSN:1354-523X    

DOI:10.1111/j.1601-0825.1996.tb00213.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

Psoriasis is a chronic, remitting and relapsing inflammatory skin disorder with a strong genetic predisposition. Psoriasis affects 1–3% of the world's population in their early lives representing a disabling condition with significant social and economic impact. Despite a great deal of research on the etiology and tissue destruction mechanisms, the disease is not well understood. The purpose of this paper is to provide current information from the literature with a special focus on oral manifestations. The major signs and symptoms presented in the oral environment of a psoriasis patient may include geographic tongue, fissure tongue, gingival and/or mucosal lesions. Inflammatory temporomandibular joint lesions have been reported in less than 5% of psoriasis patients. Multiple treatment strategies, be they topical or systemic, have been applied to these patients for symptom relief but not for cur

ISSN:1354-523X    

DOI:10.1111/j.1601-0825.1996.tb00214.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

OBJECTIVES: Renal transplant recipients (RTR) represent a large and growing population of individuals on potent immunosuppressant therapy who are at significantly greater risk of developing lip and oral mucosal disease, including lip cancer. The aims of this study were to determine the proportion of RTR receiving regular dental treatment, the dental services they used, and the relationship between the prevalence of lip and intraoral lesions and dental attendance.DESIGN: The lip and oral mucosa of 159 RTR and 160 controls were examined. Subjects were asked questions about frequency of dental attendance and which service they used.RESULTS: 57.9% RTR attended a dentist regularly compared with 51.3% controls. Among the RTR who attended a dentist regularly, 54.3% visited their general dental practitioner, and 45.6% attended a dental hospital for treatment. This was significantly different from controls where 92.7% of regular attenders used their general dental practitioner (P<0.001). Although the prevalence of oral lesions in RTR (54.7%) was more than twice as many as controls (19.4%). no significant difference was observed between RTR regular dental attenders and non‐attenders.CONCLUSIONS: This study indicates a clear need for oral health care and screening to be focused on RT

ISSN:1354-523X    

DOI:10.1111/j.1601-0825.1996.tb00215.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

Spontaneous squamous cell carcinomas of the oral region in domestic animals have the potential of providing additional information about the pathology of oral cancer and may be useful in therapeutic research. Moreover, they exhibit definite advantages over chemically induced tumors in rodents. This article provides background information on spontaneous oral squamous cell carcinomas in dogs, cats, cattle, horses and sheep and then discusses the use in research of such tumors in dogs and cats. These two species are potentially the most useful because they are numerous, suffer quite commonly from squamous cell carcinoma of the oral cavity and oro‐pharynx, and are usually allowed to live approximately normal life spans. Moreover, they are being treated routinely in veterinary hospital

ISSN:1354-523X    

DOI:10.1111/j.1601-0825.1996.tb00216.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

Wound healing in the adult is commonly compromised by excessive scar formation. In contrast, fetal wound healing is a regenerative process characterised by the conspicuous absence of scarring. Available evidence suggests that phenotypic differences between fetal and adult fibroblasts are important determinants of these distinct modes of tissue repair. In this context, a number of groups (including our own) have documented differences between fetal and adult fibroblasts with respect to such potentially relevant characteristics as migratory activity, motogenic response to cytokines and the synthesis of motility factors, cytokines and matrix macromolecules. The oral mucosa appears to be a privileged site in the adult in that it continues to display a fetal‐like mode of wound healing. Data are presented in this review indicating that a subpopulation of gingival fibroblasts expresses several ‘fetal‐like’ phenotypic characteristics. These observations are discussed in terms of both the continued expression of a fetal‐like mode of wound healing in the oral mucosa and the possible differential involvement of distinct fibroblast subpopulations in the progression of periodonta

ISSN:1354-523X    

DOI:10.1111/j.1601-0825.1996.tb00217.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

OBJECTIVE: In this paper, we review the mechanisms thought to be involved in the activation of osteoclasts in periodontitis.SUMMARY Osteoclasts are regulated by both microbial and host factors. Some factors act directly on cells of the osteoclast lineage, whereas others act indirectly through other cell types in the bone environment. The pro‐inflammatory cytokines (interleukins I and 6, tumor necrosis factors) have been implicated in the stimulation of osteoclastic resorption. The roles of the immunoregul‐atory cytokines (interleukins 2 and 4, interferon γ) are less clear, but decreased levels of these factors may contribute to periodontitis. A number of lipid mediators may be involved in stimulation of bone resorption. These include bacterial lipopolysaccharide and host‐derived platelet‐activating factor and prostaglandins. More recently, reactive oxygen intermediates and extracellular nucleo‐tides, both present at sites of inflammation, have been investigated as possible modulators of osteoclast activity. The potential use of antiresorptive therapies in periodontitis is reviewed.CONCLUSIONS: A wide range of host and bacterial factors contribute to the loss of alveolar bone in periodontitis. However, much remains to be understood about the complex mechanisms through which these factors regulate osteoclast activity. Further studies at the cellular and molecular level will lead to a better understanding of these processes and perhaps suggest new approaches for periodont

ISSN:1354-523X    

DOI:10.1111/j.1601-0825.1996.tb00218.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

Reconstructive Pre‐Prosthetic&Maxillofacial Surgery RJ Fonseca, WH Davis WB Saunders: Philadelphi

ISSN:1354-523X    

DOI:10.1111/j.1601-0825.1996.tb00219.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

ISSN:1354-523X    

DOI:10.1111/j.1601-0825.1996.tb00220.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY