摘要:

Patients with testicular germ cell tumors are highly curable with either surgery, chemotherapy, and radiation therapy or multimodality therapy. However, a subset of patients with poor prognosis disease still die of refractory and relapsed disease. Recent studies have focused on limiting therapy-related toxicities in patients with good prognosis disease and improving the survival rate in patients with poor prognosis disease.

ISSN:0963-0643    

出版商:OVID    

年代:1996

数据来源: OVID

ISSN:0963-0643    

出版商:OVID    

年代:1996

数据来源: OVID

ISSN:0963-0643    

出版商:OVID    

年代:1996

数据来源: OVID

ISSN:0963-0643    

出版商:OVID    

年代:1996

数据来源: OVID

摘要:

The outcome for patients with renal cell carcinoma has been dramatically changed by the refinement and widespread use of modern diagnostic tools. Concern about the unpredictable behaviour of renal cell carcinoma has been put aside, giving a new drive to research in all fields of this disease. Incidentally found tumours (> 50%) can frequently be treated by nephron-sparing surgery. This type of surgery is becoming more and more accepted and problems such as multifocality and the risk of local recurrence are now well documented. Improvement in surgical technique will make this approach valuable and safe.

ISSN:0963-0643    

出版商:OVID    

年代:1996

数据来源: OVID

摘要:

Classic radiological procedures failed to improve significantly the staging of localized prostate cancer. After prostate-specific antigen, some biopsy features have been successfully evaluated. The number of positive biopsy cores and the quantity of tissue core invaded by tumour appear to be closely related to prognosis and tumour volume. More recently, the detection of circulating prostate cells using reverse-transcriptase polymerase chain reaction has been developed and, with further investigation, could demonstrate prognostic value.

ISSN:0963-0643    

出版商:OVID    

年代:1996

数据来源: OVID

摘要:

Although cryosurgery remains an investigational technique for treatment of localized prostate cancer, preliminary reports from several institutions demonstrate promising results. In the short term, most patients have undetectable cancer on follow-up biopsy and very low prostate-specific antigen levels. The procedure is associated with moderate morbidity. Adequate urethral warming is particularly important in preventing urinary retention and incontinence.

ISSN:0963-0643    

出版商:OVID    

年代:1996

数据来源: OVID

摘要:

Neoadjuvant androgen deprivation therapy has consistently demonstrated a 50% decrease in the positive margin rate in patients with clinical stage T2 prostate cancer undergoing radical prostatectomy compared with patients without prior therapy. Clinical correlates in terms of changes in progression rate or survival are not yet available. Early analyses of ongoing trials show no difference between the treated or control groups in the commonly used surrogate of progression, the rate of detectable prostate-specific antigen. The adoption of neoadjuvant therapy should await more definitive results of these trials.

ISSN:0963-0643    

出版商:OVID    

年代:1996

数据来源: OVID

摘要:

Hormone refractory prostate cancer remains a challenge, but it is not as resistant to treatment as previously believed. After failure of initial hormone therapy, various treatment options are available that may provide objective remission and palliate the symptoms of disease. Advances in molecular biology together with an increased understanding of the biology of the disease will direct future therapeutic strategies.

ISSN:0963-0643    

出版商:OVID    

年代:1996

数据来源: OVID

ISSN:0963-0643    

出版商:OVID    

年代:1996

数据来源: OVID